Polymorphonuclear leukocyte function in psoriasis vulgaris

SUMMARY Polymorphonuclear leukocyte (PMN) migration was assessed in vitro using the agarose plate method in patients with psoriasis vulgaris, and compared with an age‐ and sex‐matched control group. No significant difference was found between the two groups in the PMN response to the chemotactic sub...

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Veröffentlicht in:British journal of dermatology (1951) 1987-08, Vol.117 (2), p.161-167
Hauptverfasser: PEASE, C.T., FENNELL, M., STAUGHTON, R.C.D., BREWERTON, D.A.
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container_end_page 167
container_issue 2
container_start_page 161
container_title British journal of dermatology (1951)
container_volume 117
creator PEASE, C.T.
FENNELL, M.
STAUGHTON, R.C.D.
BREWERTON, D.A.
description SUMMARY Polymorphonuclear leukocyte (PMN) migration was assessed in vitro using the agarose plate method in patients with psoriasis vulgaris, and compared with an age‐ and sex‐matched control group. No significant difference was found between the two groups in the PMN response to the chemotactic substances F–Met–Leu‐fPhe (FMLP) or zymosan activated serum (ZAS). Equally, the chemokinetic or chemotactic potential of psoriatic serum did not differ from control serum. Our results do not support a primary abnormality of PMN function in psoriasis.
doi_str_mv 10.1111/j.1365-2133.1987.tb04112.x
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No significant difference was found between the two groups in the PMN response to the chemotactic substances F–Met–Leu‐fPhe (FMLP) or zymosan activated serum (ZAS). Equally, the chemokinetic or chemotactic potential of psoriatic serum did not differ from control serum. Our results do not support a primary abnormality of PMN function in psoriasis.</description><subject>Arthritis - blood</subject><subject>Biological and medical sciences</subject><subject>Cell Movement</subject><subject>Chemotaxis, Leukocyte</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neutrophils - physiology</subject><subject>Psoriasis - blood</subject><subject>Psoriasis. Parapsoriasis. 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Parapsoriasis. Lichen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PEASE, C.T.</creatorcontrib><creatorcontrib>FENNELL, M.</creatorcontrib><creatorcontrib>STAUGHTON, R.C.D.</creatorcontrib><creatorcontrib>BREWERTON, D.A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PEASE, C.T.</au><au>FENNELL, M.</au><au>STAUGHTON, R.C.D.</au><au>BREWERTON, D.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphonuclear leukocyte function in psoriasis vulgaris</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>1987-08</date><risdate>1987</risdate><volume>117</volume><issue>2</issue><spage>161</spage><epage>167</epage><pages>161-167</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>SUMMARY Polymorphonuclear leukocyte (PMN) migration was assessed in vitro using the agarose plate method in patients with psoriasis vulgaris, and compared with an age‐ and sex‐matched control group. No significant difference was found between the two groups in the PMN response to the chemotactic substances F–Met–Leu‐fPhe (FMLP) or zymosan activated serum (ZAS). Equally, the chemokinetic or chemotactic potential of psoriatic serum did not differ from control serum. Our results do not support a primary abnormality of PMN function in psoriasis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3651338</pmid><doi>10.1111/j.1365-2133.1987.tb04112.x</doi><tpages>7</tpages></addata></record>
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subjects Arthritis - blood
Biological and medical sciences
Cell Movement
Chemotaxis, Leukocyte
Dermatology
Female
Humans
In Vitro Techniques
Male
Medical sciences
Neutrophils - physiology
Psoriasis - blood
Psoriasis. Parapsoriasis. Lichen
title Polymorphonuclear leukocyte function in psoriasis vulgaris
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