Human α 1-acid glycoprotein-exposed macrophages release interleukin 1 inhibitory activity
The concanavalin A-unreactive variants of α 1-acid glycoprotein introduced in culture medium of monocytes/macrophages induces the inhibition of thymocyte proliferative activity of interleukin 1. LPS or LPS receptors were not involved in the activity of α 1-acid glycoprotein on macrophages. α 1- acid...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1987-09, Vol.147 (2), p.710-715 |
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| container_issue | 2 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 147 |
| creator | Bories, P.N. Guenounou, M. Féger, J. Kodari, E. Agneray, J. Durand, G. |
| description | The concanavalin A-unreactive variants of α 1-acid glycoprotein introduced in culture medium of monocytes/macrophages induces the inhibition of thymocyte proliferative activity of interleukin 1. LPS or LPS receptors were not involved in the activity of α 1-acid glycoprotein on macrophages. α 1- acid glycoprotein did not show any direct effect on thymocytes whereas the monocyte/macrophage-supernatant inhibited the interleukin 1 proliferative effect. The activity of tumor necrosis factor and interleukin 2 was not altered by the α 1- acid glycoprotein-macrophage supernatant. |
| doi_str_mv | 10.1016/0006-291X(87)90988-0 |
| format | Article |
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Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Interleukin-1 - physiology</subject><subject>Lymphokines - metabolism</subject><subject>Lymphokines - pharmacology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred DBA</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - metabolism</subject><subject>Orosomucoid - metabolism</subject><subject>Orosomucoid - pharmacology</subject><subject>Peritoneal Cavity - cytology</subject><subject>Thymus Gland - cytology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM-KFDEQh4Mo67j6Bgp9ENFDa1V3upNcBFnUFRa8KIiXUJ1U70b7z5h0L85j-SI-kxlnmKOeQlFfVer3CfEY4SUCtq8AoC0rg1-ea_XCgNG6hDtig2CgrBDkXbE5IffFg5S-ASDK1pyJs1oaLbXeiK-X60hT8ftXgSW54IvrYefmbZwXDlPJP7dzYl-M5OK8vaFrTkXkgSlxEaaF48Dr9zAVmKub0IVljruC3BJuw7J7KO71NCR-dHzPxed3bz9dXJZXH99_uHhzVTqJaiklNS02nWld7ZVutSRs6l4pYPJVDoDUuI4dku_Z122lDNU9yqaTUBGwqs_Fs8PefPWPldNix5AcDwNNPK_JajBGgdL_BVHqStdYZVAewJw6pci93cYwUtxZBLt3b_di7V6s1cr-dW8hjz057l-7kf1p6Cg7958e-5QcDX2kyYV0wpTMX9f7PK8PGGdpt4GjTS7w5NiHyG6xfg7_vuMPSWehRQ</recordid><startdate>19870915</startdate><enddate>19870915</enddate><creator>Bories, P.N.</creator><creator>Guenounou, M.</creator><creator>Féger, J.</creator><creator>Kodari, E.</creator><creator>Agneray, J.</creator><creator>Durand, G.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19870915</creationdate><title>Human α 1-acid glycoprotein-exposed macrophages release interleukin 1 inhibitory activity</title><author>Bories, P.N. ; Guenounou, M. ; Féger, J. ; Kodari, E. ; Agneray, J. ; Durand, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-4a5615b96c3d78684a153f770ead20001a5cbec1adfed36279a3f145b402a0e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Division</topic><topic>Cells, Cultured</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Fundamental and applied biological sciences. 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| ispartof | Biochemical and biophysical research communications, 1987-09, Vol.147 (2), p.710-715 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Cell Division Cells, Cultured Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Interleukin-1 - physiology Lymphokines - metabolism Lymphokines - pharmacology Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C3H Mice, Inbred DBA Modulation of the immune response (stimulation, suppression) Monocytes - drug effects Monocytes - metabolism Orosomucoid - metabolism Orosomucoid - pharmacology Peritoneal Cavity - cytology Thymus Gland - cytology |
| title | Human α 1-acid glycoprotein-exposed macrophages release interleukin 1 inhibitory activity |
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