The effect of spinal cord transection on motor units in cat medial gastrocnemius muscles
We studied the properties of whole medial gastrocnemius (MG) and soleus muscles, and of 74 individual MG motor units in three cats with long‐term complete low thoracic spinal transection (TS). All animals remained paraplegic and there was considerable atrophy of MG and soleus muscles. Motor units in...
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| Veröffentlicht in: | Muscle & nerve 1984-01, Vol.7 (1), p.23-31 |
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| creator | Mayer, R. F. Burke, R. E. Toop, J. Walmsley, B. Hodgson, J. A. |
| description | We studied the properties of whole medial gastrocnemius (MG) and soleus muscles, and of 74 individual MG motor units in three cats with long‐term complete low thoracic spinal transection (TS). All animals remained paraplegic and there was considerable atrophy of MG and soleus muscles. Motor units in the MG pool were readily classified into the same groups, types FF, F(int), FR, and S, found in normal MG, but tetanic force outputs and mean fiber areas for the corresponding muscle fiber types were decreased in all unit types as were isometric twitch contraction times. The proportion of type F(int) motor units was greater (19.0%) than expected from normal samples (5.8%) and this was also true of the corresponding type 2AB muscle fibers (6.9% in TS vs 3.3% in controls). In addition, FR and S units were less numerous (17.5% each) than in control muscles (23.0% and 25.2%, respectively), and histochemical examination revealed a similar decrease in the percentage of type 2A (11.6%) and 1 (16.4%) fibers compared with controls (20.0% and 30.5%, respectively). The changes found in chronic paraplegic atrophy were different in some details from those found after chronic simple limb immobilization. |
| doi_str_mv | 10.1002/mus.880070105 |
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F. ; Burke, R. E. ; Toop, J. ; Walmsley, B. ; Hodgson, J. A.</creator><creatorcontrib>Mayer, R. F. ; Burke, R. E. ; Toop, J. ; Walmsley, B. ; Hodgson, J. A.</creatorcontrib><description>We studied the properties of whole medial gastrocnemius (MG) and soleus muscles, and of 74 individual MG motor units in three cats with long‐term complete low thoracic spinal transection (TS). All animals remained paraplegic and there was considerable atrophy of MG and soleus muscles. Motor units in the MG pool were readily classified into the same groups, types FF, F(int), FR, and S, found in normal MG, but tetanic force outputs and mean fiber areas for the corresponding muscle fiber types were decreased in all unit types as were isometric twitch contraction times. The proportion of type F(int) motor units was greater (19.0%) than expected from normal samples (5.8%) and this was also true of the corresponding type 2AB muscle fibers (6.9% in TS vs 3.3% in controls). In addition, FR and S units were less numerous (17.5% each) than in control muscles (23.0% and 25.2%, respectively), and histochemical examination revealed a similar decrease in the percentage of type 2A (11.6%) and 1 (16.4%) fibers compared with controls (20.0% and 30.5%, respectively). The changes found in chronic paraplegic atrophy were different in some details from those found after chronic simple limb immobilization.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.880070105</identifier><identifier>PMID: 6700626</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Cats ; Electrophysiology ; Female ; Hindlimb ; Histocytochemistry ; Motor Activity - physiology ; Motor Neurons - physiology ; Muscles - analysis ; Muscles - innervation ; Muscles - physiopathology ; Neural Conduction ; Paraplegia - metabolism ; Paraplegia - physiopathology ; Spinal Cord - physiology</subject><ispartof>Muscle & nerve, 1984-01, Vol.7 (1), p.23-31</ispartof><rights>Copyright © 1984 John Wiley & Sons, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3745-d4e9eb4c45327b820254a14a17dfddca506d3824b15938f1ebe9bcd4922e76f13</citedby><cites>FETCH-LOGICAL-c3745-d4e9eb4c45327b820254a14a17dfddca506d3824b15938f1ebe9bcd4922e76f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.880070105$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.880070105$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6700626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mayer, R. F.</creatorcontrib><creatorcontrib>Burke, R. E.</creatorcontrib><creatorcontrib>Toop, J.</creatorcontrib><creatorcontrib>Walmsley, B.</creatorcontrib><creatorcontrib>Hodgson, J. A.</creatorcontrib><title>The effect of spinal cord transection on motor units in cat medial gastrocnemius muscles</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>We studied the properties of whole medial gastrocnemius (MG) and soleus muscles, and of 74 individual MG motor units in three cats with long‐term complete low thoracic spinal transection (TS). All animals remained paraplegic and there was considerable atrophy of MG and soleus muscles. Motor units in the MG pool were readily classified into the same groups, types FF, F(int), FR, and S, found in normal MG, but tetanic force outputs and mean fiber areas for the corresponding muscle fiber types were decreased in all unit types as were isometric twitch contraction times. The proportion of type F(int) motor units was greater (19.0%) than expected from normal samples (5.8%) and this was also true of the corresponding type 2AB muscle fibers (6.9% in TS vs 3.3% in controls). In addition, FR and S units were less numerous (17.5% each) than in control muscles (23.0% and 25.2%, respectively), and histochemical examination revealed a similar decrease in the percentage of type 2A (11.6%) and 1 (16.4%) fibers compared with controls (20.0% and 30.5%, respectively). The changes found in chronic paraplegic atrophy were different in some details from those found after chronic simple limb immobilization.</description><subject>Animals</subject><subject>Cats</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Hindlimb</subject><subject>Histocytochemistry</subject><subject>Motor Activity - physiology</subject><subject>Motor Neurons - physiology</subject><subject>Muscles - analysis</subject><subject>Muscles - innervation</subject><subject>Muscles - physiopathology</subject><subject>Neural Conduction</subject><subject>Paraplegia - metabolism</subject><subject>Paraplegia - physiopathology</subject><subject>Spinal Cord - physiology</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9rFTEQx4Mo9bV69Cjk5G3r5NcmOcpTa6Eq4iv2FrLZWY3ubp7JLtr_3pT3LJ6EgcDMZz5MvoQ8Y3DOAPjLaS3nxgBoYKAekA0DqxuprHlINsCkaVphbx6T01K-AwAzrT4hJ60GaHm7ITe7b0hxGDAsNA207OPsRxpS7umS_VxqP6aZ1prSkjJd57gUGmca_EIn7GOlv_qy5BRmnOJaaL0njFiekEeDHws-Pb5n5Prtm932XXP18eJy--qqCUJL1fQSLXYySCW47gwHrqRntXQ_9H3wCtpeGC47pqwwA8MObRd6aTlH3Q5MnJEXB-8-p58rlsVNsQQcRz9jWoszYG3LlalgcwBDTqVkHNw-x8nnW8fA3SXppjv8b5KVf34Ur1396D19jK7O9WH-K454-3-Ze3_9-V_z8ZJYFvx9v-nzjyoXWrkvHy7cTotP_LXaOiH-AKWljvs</recordid><startdate>198401</startdate><enddate>198401</enddate><creator>Mayer, R. F.</creator><creator>Burke, R. E.</creator><creator>Toop, J.</creator><creator>Walmsley, B.</creator><creator>Hodgson, J. A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198401</creationdate><title>The effect of spinal cord transection on motor units in cat medial gastrocnemius muscles</title><author>Mayer, R. F. ; Burke, R. E. ; Toop, J. ; Walmsley, B. ; Hodgson, J. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3745-d4e9eb4c45327b820254a14a17dfddca506d3824b15938f1ebe9bcd4922e76f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Cats</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Hindlimb</topic><topic>Histocytochemistry</topic><topic>Motor Activity - physiology</topic><topic>Motor Neurons - physiology</topic><topic>Muscles - analysis</topic><topic>Muscles - innervation</topic><topic>Muscles - physiopathology</topic><topic>Neural Conduction</topic><topic>Paraplegia - metabolism</topic><topic>Paraplegia - physiopathology</topic><topic>Spinal Cord - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mayer, R. F.</creatorcontrib><creatorcontrib>Burke, R. E.</creatorcontrib><creatorcontrib>Toop, J.</creatorcontrib><creatorcontrib>Walmsley, B.</creatorcontrib><creatorcontrib>Hodgson, J. A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mayer, R. F.</au><au>Burke, R. E.</au><au>Toop, J.</au><au>Walmsley, B.</au><au>Hodgson, J. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of spinal cord transection on motor units in cat medial gastrocnemius muscles</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>1984-01</date><risdate>1984</risdate><volume>7</volume><issue>1</issue><spage>23</spage><epage>31</epage><pages>23-31</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>We studied the properties of whole medial gastrocnemius (MG) and soleus muscles, and of 74 individual MG motor units in three cats with long‐term complete low thoracic spinal transection (TS). All animals remained paraplegic and there was considerable atrophy of MG and soleus muscles. Motor units in the MG pool were readily classified into the same groups, types FF, F(int), FR, and S, found in normal MG, but tetanic force outputs and mean fiber areas for the corresponding muscle fiber types were decreased in all unit types as were isometric twitch contraction times. The proportion of type F(int) motor units was greater (19.0%) than expected from normal samples (5.8%) and this was also true of the corresponding type 2AB muscle fibers (6.9% in TS vs 3.3% in controls). In addition, FR and S units were less numerous (17.5% each) than in control muscles (23.0% and 25.2%, respectively), and histochemical examination revealed a similar decrease in the percentage of type 2A (11.6%) and 1 (16.4%) fibers compared with controls (20.0% and 30.5%, respectively). The changes found in chronic paraplegic atrophy were different in some details from those found after chronic simple limb immobilization.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6700626</pmid><doi>10.1002/mus.880070105</doi><tpages>9</tpages></addata></record> |
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| ispartof | Muscle & nerve, 1984-01, Vol.7 (1), p.23-31 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Cats Electrophysiology Female Hindlimb Histocytochemistry Motor Activity - physiology Motor Neurons - physiology Muscles - analysis Muscles - innervation Muscles - physiopathology Neural Conduction Paraplegia - metabolism Paraplegia - physiopathology Spinal Cord - physiology |
| title | The effect of spinal cord transection on motor units in cat medial gastrocnemius muscles |
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