Role of calcium ions and the heavy chain of factor XIa in the activation of human coagulation factor IX

Since optimal rates of factor IX activation by factor XIa require the presence of calcium ions and the heavy chain of the enzyme as well as the active-site-containing light chain, we have studied the effects of calcium ions and the heavy chain on the reaction kinetics. Whereas the amidolytic activit...

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Veröffentlicht in:	Biochemistry (Easton) 1987-06, Vol.26 (13), p.3768-3775
Hauptverfasser:	Sinha, Dipali, Seaman, Frances S., Walsh, Peter N.
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics ALKALI METAL COMPOUNDS ALKALINE EARTH METAL COMPOUNDS ANIMALS ANTIBODIES Antibodies, Monoclonal - immunology Antibody Specificity Antigen-Antibody Reactions BETA DECAY RADIOISOTOPES Binding Sites, Antibody Binding, Competitive BIOCHEMISTRY Biological and medical sciences BLOOD COAGULATION Blood Coagulation - drug effects Blood coagulation. Blood cells Calcium - pharmacology CALCIUM COMPOUNDS CATIONS CHARGED PARTICLES CHEMICAL ACTIVATION CHEMISTRY Coagulation factors DAYS LIVING RADIOISOTOPES ELECTRON CAPTURE RADIOISOTOPES ELECTROPHORESIS Enzyme Activation - drug effects Factor IX - metabolism Factor XI - immunology Factor XI - physiology Factor XIa Fundamental and applied biological sciences. Psychology HALIDES HALOGEN COMPOUNDS Humans IMMUNOASSAY IMMUNOLOGY INORGANIC PHOSPHORS INTERMEDIATE MASS NUCLEI IODIDES IODINE 125 IODINE COMPOUNDS IODINE ISOTOPES IONS ISOTOPE APPLICATIONS ISOTOPES Kinetics LABELLED COMPOUNDS MAMMALS MAN Molecular and cellular biology MONOCLONAL ANTIBODIES NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS PHOSPHORS PRIMATES PROTEINS RADIOASSAY RADIOIMMUNOASSAY RADIOIMMUNOLOGY RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE SODIUM COMPOUNDS SODIUM IODIDES Space life sciences TRACER TECHNIQUES TRITIUM COMPOUNDS VERTEBRATES
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