Cholinergic Modulation of the Content of Temporal Memory
The pharmacological effects of anticholinesterases (physostigmine and neostigmine) and cholinergic receptor blockers (atropine and methylatropine) on the content of temporal memory in the rat were studied with the use of a 20-s peak-interval procedure with auditory signals. Physostigmine administere...
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| Veröffentlicht in: | Behavioral neuroscience 1987-08, Vol.101 (4), p.457-464 |
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| creator | Meck, Warren H Church, Russell M |
| description | The pharmacological effects of anticholinesterases (physostigmine and neostigmine) and cholinergic receptor blockers (atropine and methylatropine) on the content of temporal memory in the rat were studied with the use of a 20-s peak-interval procedure with auditory signals. Physostigmine administered ip decreased the variability of the temporal discrimination and shifted peak times permanently leftward on the time scale in a dose-dependent fashion (0.01, 0.03, & 0.09 mg/kg). Neostigmine (0.03 mg/kg) did not produce any of these effects. Atropine administered ip increased the variability of the temporal discrimination and shifted peak times permanently rightward on the time scale in a dose-dependent fashion (0.05, 0.15, & 0.45 mg/kg). Methylatropine (0.15 mg/kg) did not produce any of these effects. Application of a scalar timing model indicated that physostigmine decreased the remembered times of reinforcement and increased sensitivity to time, whereas atropine increased the remembered times of reinforcement and decreased sensitivity to time. These results suggest that the effective level of brain acetylcholine sets the communication speed for the translation of durations measured by the internal clock into values stored in temporal memory. |
| doi_str_mv | 10.1037/0735-7044.101.4.457 |
| format | Article |
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Physostigmine administered ip decreased the variability of the temporal discrimination and shifted peak times permanently leftward on the time scale in a dose-dependent fashion (0.01, 0.03, & 0.09 mg/kg). Neostigmine (0.03 mg/kg) did not produce any of these effects. Atropine administered ip increased the variability of the temporal discrimination and shifted peak times permanently rightward on the time scale in a dose-dependent fashion (0.05, 0.15, & 0.45 mg/kg). Methylatropine (0.15 mg/kg) did not produce any of these effects. Application of a scalar timing model indicated that physostigmine decreased the remembered times of reinforcement and increased sensitivity to time, whereas atropine increased the remembered times of reinforcement and decreased sensitivity to time. 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Psychology ; Male ; Memory ; Memory - physiology ; Mental Recall - physiology ; Neostigmine ; Neostigmine - pharmacology ; Physostigmine ; Physostigmine - analogs & derivatives ; Physostigmine - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Receptors, Cholinergic - physiology ; Synaptic Transmission - drug effects ; Time Perception - physiology</subject><ispartof>Behavioral neuroscience, 1987-08, Vol.101 (4), p.457-464</ispartof><rights>1987 American Psychological Association</rights><rights>1988 INIST-CNRS</rights><rights>1987, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a483t-9834b81079b74eff6a02d4c0e482af0a0a51d178c182861749af190dc78703e93</citedby><orcidid>0000-0002-6120-4790</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7454881$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2820435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meck, Warren H</creatorcontrib><creatorcontrib>Church, Russell M</creatorcontrib><title>Cholinergic Modulation of the Content of Temporal Memory</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>The pharmacological effects of anticholinesterases (physostigmine and neostigmine) and cholinergic receptor blockers (atropine and methylatropine) on the content of temporal memory in the rat were studied with the use of a 20-s peak-interval procedure with auditory signals. Physostigmine administered ip decreased the variability of the temporal discrimination and shifted peak times permanently leftward on the time scale in a dose-dependent fashion (0.01, 0.03, & 0.09 mg/kg). Neostigmine (0.03 mg/kg) did not produce any of these effects. Atropine administered ip increased the variability of the temporal discrimination and shifted peak times permanently rightward on the time scale in a dose-dependent fashion (0.05, 0.15, & 0.45 mg/kg). Methylatropine (0.15 mg/kg) did not produce any of these effects. Application of a scalar timing model indicated that physostigmine decreased the remembered times of reinforcement and increased sensitivity to time, whereas atropine increased the remembered times of reinforcement and decreased sensitivity to time. These results suggest that the effective level of brain acetylcholine sets the communication speed for the translation of durations measured by the internal clock into values stored in temporal memory.</description><subject>Animal</subject><subject>Animals</subject><subject>Atropine</subject><subject>Atropine - pharmacology</subject><subject>Atropine Derivatives - pharmacology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain - physiology</subject><subject>Cholinergic Blocking Drugs</subject><subject>Cholinergic Fibers - physiology</subject><subject>Conditioning, Operant - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Memory</subject><subject>Memory - physiology</subject><subject>Mental Recall - physiology</subject><subject>Neostigmine</subject><subject>Neostigmine - pharmacology</subject><subject>Physostigmine</subject><subject>Physostigmine - analogs & derivatives</subject><subject>Physostigmine - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Receptors, Cholinergic - physiology</subject><subject>Synaptic Transmission - drug effects</subject><subject>Time Perception - physiology</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMGO1DAMhiMEWmYXngAhVQi4dbAbt0mOaAQL0q64LOfIk6ZsV21TkvYwb09GMxohLpysX_5sy58QbxC2CFJ9AiXrUgFRjrilLdXqmdigkaYE0PRcbC7ES3Gd0hMAEFB9Ja4qXQHJeiP07jEM_eTjr94V96FdB176MBWhK5ZHX-zCtPhpOcYHP84h8lDc-zHEwyvxouMh-dfneiN-fv3ysPtW3v24_b77fFcyabmURkvaawRl9op81zUMVUsOPOmKO2DgGltU2qGudIOKDHdooHVKK5DeyBvx8bR3juH36tNixz45Pww8-bAmq8GYimr6L4g1Gt00OoPv_gGfwhqn_IRtkCQYNE2G5AlyMaQUfWfn2I8cDxbBHu3bo1t7dJsjWrLZfp56e1697kffXmbOunP__bnPyfHQRZ5cny6Yyn9ojRn7cMJ4Zjung-O49G7wye4n_9e5P7SHlg0</recordid><startdate>19870801</startdate><enddate>19870801</enddate><creator>Meck, Warren H</creator><creator>Church, Russell M</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6120-4790</orcidid></search><sort><creationdate>19870801</creationdate><title>Cholinergic Modulation of the Content of Temporal Memory</title><author>Meck, Warren H ; Church, Russell M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a483t-9834b81079b74eff6a02d4c0e482af0a0a51d178c182861749af190dc78703e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animal</topic><topic>Animals</topic><topic>Atropine</topic><topic>Atropine - pharmacology</topic><topic>Atropine Derivatives - pharmacology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain - physiology</topic><topic>Cholinergic Blocking Drugs</topic><topic>Cholinergic Fibers - physiology</topic><topic>Conditioning, Operant - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Memory</topic><topic>Memory - physiology</topic><topic>Mental Recall - physiology</topic><topic>Neostigmine</topic><topic>Neostigmine - pharmacology</topic><topic>Physostigmine</topic><topic>Physostigmine - analogs & derivatives</topic><topic>Physostigmine - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Receptors, Cholinergic - physiology</topic><topic>Synaptic Transmission - drug effects</topic><topic>Time Perception - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meck, Warren H</creatorcontrib><creatorcontrib>Church, Russell M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Access via APA PsycArticles® (ProQuest)</collection><collection>ProQuest One Psychology</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meck, Warren H</au><au>Church, Russell M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholinergic Modulation of the Content of Temporal Memory</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>1987-08-01</date><risdate>1987</risdate><volume>101</volume><issue>4</issue><spage>457</spage><epage>464</epage><pages>457-464</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>The pharmacological effects of anticholinesterases (physostigmine and neostigmine) and cholinergic receptor blockers (atropine and methylatropine) on the content of temporal memory in the rat were studied with the use of a 20-s peak-interval procedure with auditory signals. Physostigmine administered ip decreased the variability of the temporal discrimination and shifted peak times permanently leftward on the time scale in a dose-dependent fashion (0.01, 0.03, & 0.09 mg/kg). Neostigmine (0.03 mg/kg) did not produce any of these effects. Atropine administered ip increased the variability of the temporal discrimination and shifted peak times permanently rightward on the time scale in a dose-dependent fashion (0.05, 0.15, & 0.45 mg/kg). Methylatropine (0.15 mg/kg) did not produce any of these effects. Application of a scalar timing model indicated that physostigmine decreased the remembered times of reinforcement and increased sensitivity to time, whereas atropine increased the remembered times of reinforcement and decreased sensitivity to time. These results suggest that the effective level of brain acetylcholine sets the communication speed for the translation of durations measured by the internal clock into values stored in temporal memory.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>2820435</pmid><doi>10.1037/0735-7044.101.4.457</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6120-4790</orcidid></addata></record> |
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| ispartof | Behavioral neuroscience, 1987-08, Vol.101 (4), p.457-464 |
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| subjects | Animal Animals Atropine Atropine - pharmacology Atropine Derivatives - pharmacology Behavioral psychophysiology Biological and medical sciences Brain - physiology Cholinergic Blocking Drugs Cholinergic Fibers - physiology Conditioning, Operant - physiology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Male Memory Memory - physiology Mental Recall - physiology Neostigmine Neostigmine - pharmacology Physostigmine Physostigmine - analogs & derivatives Physostigmine - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Receptors, Cholinergic - physiology Synaptic Transmission - drug effects Time Perception - physiology |
| title | Cholinergic Modulation of the Content of Temporal Memory |
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