Physiologic Correlates of Airway Collapse in Chronic Airflow Obstruction
Forty percent of 89 patients with chronic airflow obstruction (CAO) demonstrated maximum expiration flow-volume (MEFV) patterns consistent with sudden collapse or marked narrowing of large central airways. In contrast, 43 percent of the CAO patients demonstrated a curvilinear (C) pattern; the remain...
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| Veröffentlicht in: | Chest 1984-04, Vol.85 (4), p.476-481 |
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| creator | Healy, Francis Wilson, Archie F. Fairshter, Ronald D. |
| description | Forty percent of 89 patients with chronic airflow obstruction (CAO) demonstrated maximum expiration flow-volume (MEFV) patterns
consistent with sudden collapse or marked narrowing of large central airways. In contrast, 43 percent of the CAO patients
demonstrated a curvilinear (C) pattern; the remainder (17 percent) were intermediate. Volume displacement plethysmography
indicated that the airway collapse (AC) pattern was influenced by, but was not solely, a gas compression artifact. Airway
collapse patients had more obstruction and hyperinflation than C patients and also had decreased diffusing capacity, absence
of density dependence, reduced lung recoil, and no effort dependence of airflow. Bronchodilator administration in AC patients
typically produced large reduction of residual volume and increase of vital capacity, with a smaller increase of airflow.
These data suggest that AC patients have significant, partially reversible peripheral airways obstruction plus emphysema.
Possible determinants of AC include reduced central airway support, increased peripheral resistance, loss of lung recoil,
and increased pleural pressures during forced expiration. The MEFV contour appears to evolve from normal to curvilinear to
the AC pattern as the severity of airflow obstruction worsens. |
| doi_str_mv | 10.1378/chest.85.4.476 |
| format | Article |
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consistent with sudden collapse or marked narrowing of large central airways. In contrast, 43 percent of the CAO patients
demonstrated a curvilinear (C) pattern; the remainder (17 percent) were intermediate. Volume displacement plethysmography
indicated that the airway collapse (AC) pattern was influenced by, but was not solely, a gas compression artifact. Airway
collapse patients had more obstruction and hyperinflation than C patients and also had decreased diffusing capacity, absence
of density dependence, reduced lung recoil, and no effort dependence of airflow. Bronchodilator administration in AC patients
typically produced large reduction of residual volume and increase of vital capacity, with a smaller increase of airflow.
These data suggest that AC patients have significant, partially reversible peripheral airways obstruction plus emphysema.
Possible determinants of AC include reduced central airway support, increased peripheral resistance, loss of lung recoil,
and increased pleural pressures during forced expiration. The MEFV contour appears to evolve from normal to curvilinear to
the AC pattern as the severity of airflow obstruction worsens.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.85.4.476</identifier><identifier>PMID: 6705575</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Bronchodilator Agents - therapeutic use ; Chronic obstructive pulmonary disease, asthma ; Female ; Forced Expiratory Volume ; Humans ; Lung Compliance ; Lung Diseases, Obstructive - drug therapy ; Lung Diseases, Obstructive - physiopathology ; Male ; Medical sciences ; Methacholine Compounds - pharmacology ; Middle Aged ; Pneumology ; Pulmonary Diffusing Capacity ; Pulmonary Wedge Pressure ; Respiratory Function Tests</subject><ispartof>Chest, 1984-04, Vol.85 (4), p.476-481</ispartof><rights>1984 The American College of Chest Physicians</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-2f9806a56340bb26b80463d215b8301f6cd598dd424ed128878e52622c3e345f3</citedby><cites>FETCH-LOGICAL-c388t-2f9806a56340bb26b80463d215b8301f6cd598dd424ed128878e52622c3e345f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9566510$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6705575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Healy, Francis</creatorcontrib><creatorcontrib>Wilson, Archie F.</creatorcontrib><creatorcontrib>Fairshter, Ronald D.</creatorcontrib><title>Physiologic Correlates of Airway Collapse in Chronic Airflow Obstruction</title><title>Chest</title><addtitle>Chest</addtitle><description>Forty percent of 89 patients with chronic airflow obstruction (CAO) demonstrated maximum expiration flow-volume (MEFV) patterns
consistent with sudden collapse or marked narrowing of large central airways. In contrast, 43 percent of the CAO patients
demonstrated a curvilinear (C) pattern; the remainder (17 percent) were intermediate. Volume displacement plethysmography
indicated that the airway collapse (AC) pattern was influenced by, but was not solely, a gas compression artifact. Airway
collapse patients had more obstruction and hyperinflation than C patients and also had decreased diffusing capacity, absence
of density dependence, reduced lung recoil, and no effort dependence of airflow. Bronchodilator administration in AC patients
typically produced large reduction of residual volume and increase of vital capacity, with a smaller increase of airflow.
These data suggest that AC patients have significant, partially reversible peripheral airways obstruction plus emphysema.
Possible determinants of AC include reduced central airway support, increased peripheral resistance, loss of lung recoil,
and increased pleural pressures during forced expiration. The MEFV contour appears to evolve from normal to curvilinear to
the AC pattern as the severity of airflow obstruction worsens.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Bronchodilator Agents - therapeutic use</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Lung Compliance</subject><subject>Lung Diseases, Obstructive - drug therapy</subject><subject>Lung Diseases, Obstructive - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methacholine Compounds - pharmacology</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Pulmonary Diffusing Capacity</subject><subject>Pulmonary Wedge Pressure</subject><subject>Respiratory Function Tests</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UDtP5DAQtk4gWODa605KgegS_I5TohUvCYkroLYcZ0KMvPFiJ6z2359hV3DNVSPP9xp_CP0iuCKsVpd2gDRVSlS84rX8gRakYaRkgrMDtMCY0JLJhh6jk5RecX6TRh6hI1ljIWqxQHd_hm1ywYcXZ4tliBG8mSAVoS-uXNyYbV56b9YJCjcWyyGGMRMz1PuwKR7bNMXZTi6MZ-iwNz7Bz_08Rc8310_Lu_Lh8fZ-efVQWqbUVNK-UVgaIRnHbUtlqzCXrKNEtIph0kvbiUZ1HaccOkKVqhUIKim1DBgXPTtFFzvfdQxvc_67XrlkId84QpiTVrhpSF3XmVjtiDaGlCL0eh3dysStJlh_VKc_q9NKaK5zdVnwe-88tyvovuj7rjJ-vsdNssb30YzWpS9aI6QUBH_nDu5l2LgIOq2M99mU7RJfwxxH4__JVTsB5NreHUSdrIPRQpfFdtJdcP87-S9kjZrc</recordid><startdate>198404</startdate><enddate>198404</enddate><creator>Healy, Francis</creator><creator>Wilson, Archie F.</creator><creator>Fairshter, Ronald D.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198404</creationdate><title>Physiologic Correlates of Airway Collapse in Chronic Airflow Obstruction</title><author>Healy, Francis ; Wilson, Archie F. ; Fairshter, Ronald D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-2f9806a56340bb26b80463d215b8301f6cd598dd424ed128878e52622c3e345f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Bronchodilator Agents - therapeutic use</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Lung Compliance</topic><topic>Lung Diseases, Obstructive - drug therapy</topic><topic>Lung Diseases, Obstructive - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methacholine Compounds - pharmacology</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Pulmonary Diffusing Capacity</topic><topic>Pulmonary Wedge Pressure</topic><topic>Respiratory Function Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Healy, Francis</creatorcontrib><creatorcontrib>Wilson, Archie F.</creatorcontrib><creatorcontrib>Fairshter, Ronald D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Healy, Francis</au><au>Wilson, Archie F.</au><au>Fairshter, Ronald D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physiologic Correlates of Airway Collapse in Chronic Airflow Obstruction</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1984-04</date><risdate>1984</risdate><volume>85</volume><issue>4</issue><spage>476</spage><epage>481</epage><pages>476-481</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Forty percent of 89 patients with chronic airflow obstruction (CAO) demonstrated maximum expiration flow-volume (MEFV) patterns
consistent with sudden collapse or marked narrowing of large central airways. In contrast, 43 percent of the CAO patients
demonstrated a curvilinear (C) pattern; the remainder (17 percent) were intermediate. Volume displacement plethysmography
indicated that the airway collapse (AC) pattern was influenced by, but was not solely, a gas compression artifact. Airway
collapse patients had more obstruction and hyperinflation than C patients and also had decreased diffusing capacity, absence
of density dependence, reduced lung recoil, and no effort dependence of airflow. Bronchodilator administration in AC patients
typically produced large reduction of residual volume and increase of vital capacity, with a smaller increase of airflow.
These data suggest that AC patients have significant, partially reversible peripheral airways obstruction plus emphysema.
Possible determinants of AC include reduced central airway support, increased peripheral resistance, loss of lung recoil,
and increased pleural pressures during forced expiration. The MEFV contour appears to evolve from normal to curvilinear to
the AC pattern as the severity of airflow obstruction worsens.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>6705575</pmid><doi>10.1378/chest.85.4.476</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Biological and medical sciences Bronchodilator Agents - therapeutic use Chronic obstructive pulmonary disease, asthma Female Forced Expiratory Volume Humans Lung Compliance Lung Diseases, Obstructive - drug therapy Lung Diseases, Obstructive - physiopathology Male Medical sciences Methacholine Compounds - pharmacology Middle Aged Pneumology Pulmonary Diffusing Capacity Pulmonary Wedge Pressure Respiratory Function Tests |
| title | Physiologic Correlates of Airway Collapse in Chronic Airflow Obstruction |
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