Estradiol, Estrone, and Gonadotropin Levels After Use of Vaginal Estradiol
The vaginal absorption of 0.5-mg tablets of micronized estradiol was evaluated in postmenopausal women. In a single-dose study, one hour after insertion, a 5.3-fold rise in mean serum estradiol levels and 1.5-fold rise in mean serum estrone levels were observed. Mean levels of luteinizing hormone an...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1984-04, Vol.63 (4), p.441-444 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | MARTIN, PURVIS L GREANEY, MARTIN 0 BURNIER, ANDRE M BROOKS, PATRICIA M YEN, SAMUEL S C QUIGLEY, M E TED |
| description | The vaginal absorption of 0.5-mg tablets of micronized estradiol was evaluated in postmenopausal women. In a single-dose study, one hour after insertion, a 5.3-fold rise in mean serum estradiol levels and 1.5-fold rise in mean serum estrone levels were observed. Mean levels of luteinizing hormone and follicle-stimulating hormone were significantly depressed. In a three-week alternate-day regimen, mean serum levels of estradiol were consistently two to three times greater than those of estrone 12 hours after insertion. Vaginal absorption of micronized estradiol tablets into the systemic circulation was found to be rapid and efficient. The vaginal route was acceptable and well tolerated by patients. In addition, the major conversion of estradiol to estrone that follows oral or sublingual administration was reduced. The vagina may be a preferred alternate route for estrogen replacement therapy in selected patients. |
| format | Article |
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In a single-dose study, one hour after insertion, a 5.3-fold rise in mean serum estradiol levels and 1.5-fold rise in mean serum estrone levels were observed. Mean levels of luteinizing hormone and follicle-stimulating hormone were significantly depressed. In a three-week alternate-day regimen, mean serum levels of estradiol were consistently two to three times greater than those of estrone 12 hours after insertion. Vaginal absorption of micronized estradiol tablets into the systemic circulation was found to be rapid and efficient. The vaginal route was acceptable and well tolerated by patients. In addition, the major conversion of estradiol to estrone that follows oral or sublingual administration was reduced. The vagina may be a preferred alternate route for estrogen replacement therapy in selected patients.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 6422370</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Biological and medical sciences ; Drug Administration Schedule ; Estradiol - administration & dosage ; Estradiol - blood ; Estrone - blood ; Female ; Follicle Stimulating Hormone - blood ; Genital system. Reproduction ; Gonadotropins, Pituitary - blood ; Humans ; Luteinizing Hormone - blood ; Medical sciences ; Menstruation ; Middle Aged ; Pharmacology. Drug treatments ; Time Factors ; Vagina</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1984-04, Vol.63 (4), p.441-444</ispartof><rights>1984 The American College of Obstetricians and Gynecologists</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9233397$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6422370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARTIN, PURVIS L</creatorcontrib><creatorcontrib>GREANEY, MARTIN 0</creatorcontrib><creatorcontrib>BURNIER, ANDRE M</creatorcontrib><creatorcontrib>BROOKS, PATRICIA M</creatorcontrib><creatorcontrib>YEN, SAMUEL S C</creatorcontrib><creatorcontrib>QUIGLEY, M E TED</creatorcontrib><title>Estradiol, Estrone, and Gonadotropin Levels After Use of Vaginal Estradiol</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>The vaginal absorption of 0.5-mg tablets of micronized estradiol was evaluated in postmenopausal women. In a single-dose study, one hour after insertion, a 5.3-fold rise in mean serum estradiol levels and 1.5-fold rise in mean serum estrone levels were observed. Mean levels of luteinizing hormone and follicle-stimulating hormone were significantly depressed. In a three-week alternate-day regimen, mean serum levels of estradiol were consistently two to three times greater than those of estrone 12 hours after insertion. Vaginal absorption of micronized estradiol tablets into the systemic circulation was found to be rapid and efficient. The vaginal route was acceptable and well tolerated by patients. In addition, the major conversion of estradiol to estrone that follows oral or sublingual administration was reduced. The vagina may be a preferred alternate route for estrogen replacement therapy in selected patients.</description><subject>Biological and medical sciences</subject><subject>Drug Administration Schedule</subject><subject>Estradiol - administration & dosage</subject><subject>Estradiol - blood</subject><subject>Estrone - blood</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Genital system. Reproduction</subject><subject>Gonadotropins, Pituitary - blood</subject><subject>Humans</subject><subject>Luteinizing Hormone - blood</subject><subject>Medical sciences</subject><subject>Menstruation</subject><subject>Middle Aged</subject><subject>Pharmacology. 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Reproduction</topic><topic>Gonadotropins, Pituitary - blood</topic><topic>Humans</topic><topic>Luteinizing Hormone - blood</topic><topic>Medical sciences</topic><topic>Menstruation</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Time Factors</topic><topic>Vagina</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MARTIN, PURVIS L</creatorcontrib><creatorcontrib>GREANEY, MARTIN 0</creatorcontrib><creatorcontrib>BURNIER, ANDRE M</creatorcontrib><creatorcontrib>BROOKS, PATRICIA M</creatorcontrib><creatorcontrib>YEN, SAMUEL S C</creatorcontrib><creatorcontrib>QUIGLEY, M E TED</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MARTIN, PURVIS L</au><au>GREANEY, MARTIN 0</au><au>BURNIER, ANDRE M</au><au>BROOKS, PATRICIA M</au><au>YEN, SAMUEL S C</au><au>QUIGLEY, M E TED</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estradiol, Estrone, and Gonadotropin Levels After Use of Vaginal Estradiol</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1984-04</date><risdate>1984</risdate><volume>63</volume><issue>4</issue><spage>441</spage><epage>444</epage><pages>441-444</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>The vaginal absorption of 0.5-mg tablets of micronized estradiol was evaluated in postmenopausal women. In a single-dose study, one hour after insertion, a 5.3-fold rise in mean serum estradiol levels and 1.5-fold rise in mean serum estrone levels were observed. Mean levels of luteinizing hormone and follicle-stimulating hormone were significantly depressed. In a three-week alternate-day regimen, mean serum levels of estradiol were consistently two to three times greater than those of estrone 12 hours after insertion. Vaginal absorption of micronized estradiol tablets into the systemic circulation was found to be rapid and efficient. The vaginal route was acceptable and well tolerated by patients. In addition, the major conversion of estradiol to estrone that follows oral or sublingual administration was reduced. The vagina may be a preferred alternate route for estrogen replacement therapy in selected patients.</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>6422370</pmid><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 1984-04, Vol.63 (4), p.441-444 |
| issn | 0029-7844 1873-233X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Biological and medical sciences Drug Administration Schedule Estradiol - administration & dosage Estradiol - blood Estrone - blood Female Follicle Stimulating Hormone - blood Genital system. Reproduction Gonadotropins, Pituitary - blood Humans Luteinizing Hormone - blood Medical sciences Menstruation Middle Aged Pharmacology. Drug treatments Time Factors Vagina |
| title | Estradiol, Estrone, and Gonadotropin Levels After Use of Vaginal Estradiol |
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