κ and δ -opioid receptor agonists differentially inhibit striatal dopamine and acetylcholine release
At least three different families of endogenous opioid peptides, the enkephalins, endorphins and dynorphins, are present in the mammalian central nervous system (CNS). Immuno-cytochemical studies have demonstrated their localization in neurones 1–8 , which supports the view that these peptides may h...
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| Veröffentlicht in: | Nature (London) 1984-03, Vol.308 (5956), p.278-280 |
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| creator | Mulder, Arie H Wardeh, George Hogenboom, Francois Frankhuyzen, Abraham L |
| description | At least three different families of endogenous opioid peptides, the enkephalins, endorphins and dynorphins, are present in the mammalian central nervous system (CNS). Immuno-cytochemical studies have demonstrated their localization in neurones
1–8
, which supports the view that these peptides may have a role as neurotransmitters or neuromodulators. However, the target cells and cellular processes acted upon by the opioid peptides are still largely unknown. One possible function of neuropeptides, including the opioid peptides, may be presynaptic modulation of neurotransmission in certain neuronal pathways, for example, by inhibition or promotion of neurotransmitter release from the nerve terminals
9–12
. Here we report that dynorphin and some benzomorphans potently and selectively inhibit the release of (radiolabelled) dopamine from slices of rat corpus striatum, by activating
κ
-opioid receptors. In contrast, [Leu
5
]enkephalin and [D-Ala
2
, D-Leu
5
]enkephalin selectively inhibit acetylcholine release by activating
δ
-opioid receptors. |
| doi_str_mv | 10.1038/308278a0 |
| format | Article |
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1–8
, which supports the view that these peptides may have a role as neurotransmitters or neuromodulators. However, the target cells and cellular processes acted upon by the opioid peptides are still largely unknown. One possible function of neuropeptides, including the opioid peptides, may be presynaptic modulation of neurotransmission in certain neuronal pathways, for example, by inhibition or promotion of neurotransmitter release from the nerve terminals
9–12
. Here we report that dynorphin and some benzomorphans potently and selectively inhibit the release of (radiolabelled) dopamine from slices of rat corpus striatum, by activating
κ
-opioid receptors. In contrast, [Leu
5
]enkephalin and [D-Ala
2
, D-Leu
5
]enkephalin selectively inhibit acetylcholine release by activating
δ
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1–8
, which supports the view that these peptides may have a role as neurotransmitters or neuromodulators. However, the target cells and cellular processes acted upon by the opioid peptides are still largely unknown. One possible function of neuropeptides, including the opioid peptides, may be presynaptic modulation of neurotransmission in certain neuronal pathways, for example, by inhibition or promotion of neurotransmitter release from the nerve terminals
9–12
. Here we report that dynorphin and some benzomorphans potently and selectively inhibit the release of (radiolabelled) dopamine from slices of rat corpus striatum, by activating
κ
-opioid receptors. In contrast, [Leu
5
]enkephalin and [D-Ala
2
, D-Leu
5
]enkephalin selectively inhibit acetylcholine release by activating
δ
-opioid receptors.</description><subject>Acetylcholine - metabolism</subject><subject>Animals</subject><subject>Benzomorphans - analogs & derivatives</subject><subject>Benzomorphans - pharmacology</subject><subject>Corpus Striatum - physiology</subject><subject>Cyclazocine - analogs & derivatives</subject><subject>Cyclazocine - pharmacology</subject><subject>Dopamine - metabolism</subject><subject>Dynorphins</subject><subject>Endorphins - pharmacology</subject><subject>Enkephalin, Leucine - pharmacology</subject><subject>Ethylketocyclazocine - analogs & derivatives</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Naloxone - pharmacology</subject><subject>Peptide Fragments - pharmacology</subject><subject>Potassium - pharmacology</subject><subject>Rats</subject><subject>Receptors, Opioid - physiology</subject><subject>Receptors, Opioid, delta</subject><subject>Receptors, Opioid, kappa</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAQhq0KRLe0Ul-gyKcKDqFjJ7GdI0JtQVqJy94jrzMGI6-d2s5h34sTD8EzNbDbPVXi4pH8f_pG8xPylcElg1r9qEFxqTR8IAvWSFE1QskjsgDgqgJVi4_kU86PANAy2ZyQE1FzDowtiH15pjoM9OWJVnF00Q00ocGxxET1fQwul0wHZy0mDMVp77fUhQe3doXmkpwu2tMhjnrjAr6ZtMGy9eYh-tefhB51xs_k2Gqf8ct-npLVr5-r65tqeff79vpqWRmuGFR12zKxVq0ZlLKDAdsKI2RtxSCbrlszAUqgkWBtB6i4mI9omk7NK-dXNPUp-b7Tjin-mTCXfuOyQe91wDjlXkGnpOTyXZA10Ele8xk834EmxZwT2n5MbqPTtmfQv1bf_6t-Rr_tndN6g8MB3Hc95xe7PM9JuMfUP8YphbmO_7nOdmzQZUp4cB2AvxAJlsQ</recordid><startdate>19840315</startdate><enddate>19840315</enddate><creator>Mulder, Arie H</creator><creator>Wardeh, George</creator><creator>Hogenboom, Francois</creator><creator>Frankhuyzen, Abraham L</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19840315</creationdate><title>κ and δ -opioid receptor agonists differentially inhibit striatal dopamine and acetylcholine release</title><author>Mulder, Arie H ; Wardeh, George ; Hogenboom, Francois ; Frankhuyzen, Abraham L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2810-35516b85cd88fdc0f56c673f6d7499b16086ec70ff90e8262204498ace498643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Acetylcholine - metabolism</topic><topic>Animals</topic><topic>Benzomorphans - analogs & derivatives</topic><topic>Benzomorphans - pharmacology</topic><topic>Corpus Striatum - physiology</topic><topic>Cyclazocine - analogs & derivatives</topic><topic>Cyclazocine - pharmacology</topic><topic>Dopamine - metabolism</topic><topic>Dynorphins</topic><topic>Endorphins - pharmacology</topic><topic>Enkephalin, Leucine - pharmacology</topic><topic>Ethylketocyclazocine - analogs & derivatives</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Naloxone - pharmacology</topic><topic>Peptide Fragments - pharmacology</topic><topic>Potassium - pharmacology</topic><topic>Rats</topic><topic>Receptors, Opioid - physiology</topic><topic>Receptors, Opioid, delta</topic><topic>Receptors, Opioid, kappa</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mulder, Arie H</creatorcontrib><creatorcontrib>Wardeh, George</creatorcontrib><creatorcontrib>Hogenboom, Francois</creatorcontrib><creatorcontrib>Frankhuyzen, Abraham L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mulder, Arie H</au><au>Wardeh, George</au><au>Hogenboom, Francois</au><au>Frankhuyzen, Abraham L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>κ and δ -opioid receptor agonists differentially inhibit striatal dopamine and acetylcholine release</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1984-03-15</date><risdate>1984</risdate><volume>308</volume><issue>5956</issue><spage>278</spage><epage>280</epage><pages>278-280</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>At least three different families of endogenous opioid peptides, the enkephalins, endorphins and dynorphins, are present in the mammalian central nervous system (CNS). Immuno-cytochemical studies have demonstrated their localization in neurones
1–8
, which supports the view that these peptides may have a role as neurotransmitters or neuromodulators. However, the target cells and cellular processes acted upon by the opioid peptides are still largely unknown. One possible function of neuropeptides, including the opioid peptides, may be presynaptic modulation of neurotransmission in certain neuronal pathways, for example, by inhibition or promotion of neurotransmitter release from the nerve terminals
9–12
. Here we report that dynorphin and some benzomorphans potently and selectively inhibit the release of (radiolabelled) dopamine from slices of rat corpus striatum, by activating
κ
-opioid receptors. In contrast, [Leu
5
]enkephalin and [D-Ala
2
, D-Leu
5
]enkephalin selectively inhibit acetylcholine release by activating
δ
-opioid receptors.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6322011</pmid><doi>10.1038/308278a0</doi><tpages>3</tpages></addata></record> |
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| ispartof | Nature (London), 1984-03, Vol.308 (5956), p.278-280 |
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| subjects | Acetylcholine - metabolism Animals Benzomorphans - analogs & derivatives Benzomorphans - pharmacology Corpus Striatum - physiology Cyclazocine - analogs & derivatives Cyclazocine - pharmacology Dopamine - metabolism Dynorphins Endorphins - pharmacology Enkephalin, Leucine - pharmacology Ethylketocyclazocine - analogs & derivatives Humanities and Social Sciences letter Male multidisciplinary Naloxone - pharmacology Peptide Fragments - pharmacology Potassium - pharmacology Rats Receptors, Opioid - physiology Receptors, Opioid, delta Receptors, Opioid, kappa Science Science (multidisciplinary) |
| title | κ and δ -opioid receptor agonists differentially inhibit striatal dopamine and acetylcholine release |
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