In Vitro Assessment of Cytotoxic Agents in Murine Cancers: Comparison Between Antiproliferative and Antimetabolic Assays

Different methods were compared for the in vitro evaluation of the therapeutic effects of the antineoplastic agents doxorubicin, cisplatin, fluorouracil, and vinblastine sulfate in a model system of murine tumor cell lines consisting of L1210 leukemia, P815 mast cell leukemia, and B16 melanoma. Exce...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1984-03, Vol.72 (3), p.661-666
Hauptverfasser:	Roobol, Cornells, Sips, Henriette C. M., Theunissen, Joseph, Atassi, Ghanem, Bernheim, Jan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Line Cell Survival - drug effects Cisplatin - therapeutic use DNA Replication - drug effects Doxorubicin - therapeutic use Fluorouracil - therapeutic use General aspects Kinetics Leukemia L1210 - drug therapy Leukemia L1210 - physiopathology Leukemia, Experimental - drug therapy Leukemia, Experimental - physiopathology Medical sciences Melanoma - drug therapy Melanoma - physiopathology Mice Pharmacology. Drug treatments Structure-Activity Relationship Vinblastine - therapeutic use
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