Preoperative chemotherapy and radiation therapy for patients with cancer of the esophagus: a potentially curative approach
Twenty-one patients with squamous cell cancer of the esophagus were entered into a pilot clinical trial using preoperative chemotherapy (5-fluorouracil and cis-platinum) and radiation with the intent of improving cure rate and survival. After the preoperative treatment was complete, 15 patients (71%...
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| Veröffentlicht in: | Journal of clinical oncology 1984-02, Vol.2 (2), p.75-79 |
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| container_title | Journal of clinical oncology |
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| creator | Leichman, L Steiger, Z Seydel, H G Dindogru, A Kinzie, J Toben, S MacKenzie, G Shell, J |
| description | Twenty-one patients with squamous cell cancer of the esophagus were entered into a pilot clinical trial using preoperative chemotherapy (5-fluorouracil and cis-platinum) and radiation with the intent of improving cure rate and survival. After the preoperative treatment was complete, 15 patients (71%) were resected for cure. Seven (47%) of 15 had no histologic evidence of cancer in the resected esophagus, but two of these had microscopic cancer in resected lymph nodes. The median survival for all patients entered in the trial was 18 months, whereas for those with no cancer in the resected esophagus the median survival was 24 months. The six patients who either refused surgery (two patients) or were unresectable at surgery (four patients) died within nine months. Our conclusion in this trial is that survival and potential cure are clearly linked to successfully clearing the esophagus and nodes of histologic evidence of tumor through preoperative treatment. |
| doi_str_mv | 10.1200/JCO.1984.2.2.75 |
| format | Article |
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After the preoperative treatment was complete, 15 patients (71%) were resected for cure. Seven (47%) of 15 had no histologic evidence of cancer in the resected esophagus, but two of these had microscopic cancer in resected lymph nodes. The median survival for all patients entered in the trial was 18 months, whereas for those with no cancer in the resected esophagus the median survival was 24 months. The six patients who either refused surgery (two patients) or were unresectable at surgery (four patients) died within nine months. Our conclusion in this trial is that survival and potential cure are clearly linked to successfully clearing the esophagus and nodes of histologic evidence of tumor through preoperative treatment.</description><identifier>ISSN: 0732-183X</identifier><identifier>EISSN: 1527-7755</identifier><identifier>DOI: 10.1200/JCO.1984.2.2.75</identifier><identifier>PMID: 6538224</identifier><language>eng</language><publisher>United States: American Society of Clinical Oncology</publisher><subject>Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - surgery ; Cisplatin - administration & dosage ; Combined Modality Therapy ; Esophageal Neoplasms - drug therapy ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - radiotherapy ; Esophageal Neoplasms - surgery ; Female ; Fluorouracil - administration & dosage ; Humans ; Male ; Middle Aged</subject><ispartof>Journal of clinical oncology, 1984-02, Vol.2 (2), p.75-79</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-2fd7b39d0a9020e200bd819787e8d9af4a8cf343523bb5af36b6a190c277d9c23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3729,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6538224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leichman, L</creatorcontrib><creatorcontrib>Steiger, Z</creatorcontrib><creatorcontrib>Seydel, H G</creatorcontrib><creatorcontrib>Dindogru, A</creatorcontrib><creatorcontrib>Kinzie, J</creatorcontrib><creatorcontrib>Toben, S</creatorcontrib><creatorcontrib>MacKenzie, G</creatorcontrib><creatorcontrib>Shell, J</creatorcontrib><title>Preoperative chemotherapy and radiation therapy for patients with cancer of the esophagus: a potentially curative approach</title><title>Journal of clinical oncology</title><addtitle>J Clin Oncol</addtitle><description>Twenty-one patients with squamous cell cancer of the esophagus were entered into a pilot clinical trial using preoperative chemotherapy (5-fluorouracil and cis-platinum) and radiation with the intent of improving cure rate and survival. After the preoperative treatment was complete, 15 patients (71%) were resected for cure. Seven (47%) of 15 had no histologic evidence of cancer in the resected esophagus, but two of these had microscopic cancer in resected lymph nodes. The median survival for all patients entered in the trial was 18 months, whereas for those with no cancer in the resected esophagus the median survival was 24 months. The six patients who either refused surgery (two patients) or were unresectable at surgery (four patients) died within nine months. Our conclusion in this trial is that survival and potential cure are clearly linked to successfully clearing the esophagus and nodes of histologic evidence of tumor through preoperative treatment.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Cisplatin - administration & dosage</subject><subject>Combined Modality Therapy</subject><subject>Esophageal Neoplasms - drug therapy</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - radiotherapy</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><issn>0732-183X</issn><issn>1527-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1r3DAQxUVpSDdpzzkFBIXcvNGHZcm9lSWfLCSHBHoTY1lee7EtV7KzbP76aFknzEHMvN-8QQ-hC0qWlBFy_bh6WtJcpUsWS4pvaEEFk4mUQnxHCyI5S6ji_36gsxC2hNBUcXGKTjPBFWPpAr0_e-sG62Fs3iw2te3cWMd22GPoS-yhbKLkevw5rZzHQxzZfgx414w1NtAb67GrDgy2wQ01bKbwBwMe3Bi5Btp2j800H4Fh8A5M_ROdVNAG-2t-z9Hr7c3L6j5ZP909rP6uE8MZGRNWlbLgeUkgJ4zY-OmiVDSXSlpV5lCloEzFUy4YLwoBFc-KDGhODJOyzA3j5-jq6BvP_p9sGHXXBGPbFnrrpqAVyVWWsSyC10fQeBeCt5UefNOB32tK9CFtHdPWh7Q1iyVF3Licraeis-UXP8cb9d9HvW429a7xVocuhhFpprfGzS4fnZaKEQ</recordid><startdate>198402</startdate><enddate>198402</enddate><creator>Leichman, L</creator><creator>Steiger, Z</creator><creator>Seydel, H G</creator><creator>Dindogru, A</creator><creator>Kinzie, J</creator><creator>Toben, S</creator><creator>MacKenzie, G</creator><creator>Shell, J</creator><general>American Society of Clinical Oncology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198402</creationdate><title>Preoperative chemotherapy and radiation therapy for patients with cancer of the esophagus: a potentially curative approach</title><author>Leichman, L ; Steiger, Z ; Seydel, H G ; Dindogru, A ; Kinzie, J ; Toben, S ; MacKenzie, G ; Shell, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-2fd7b39d0a9020e200bd819787e8d9af4a8cf343523bb5af36b6a190c277d9c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Cisplatin - administration & dosage</topic><topic>Combined Modality Therapy</topic><topic>Esophageal Neoplasms - drug therapy</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - radiotherapy</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Female</topic><topic>Fluorouracil - administration & dosage</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leichman, L</creatorcontrib><creatorcontrib>Steiger, Z</creatorcontrib><creatorcontrib>Seydel, H G</creatorcontrib><creatorcontrib>Dindogru, A</creatorcontrib><creatorcontrib>Kinzie, J</creatorcontrib><creatorcontrib>Toben, S</creatorcontrib><creatorcontrib>MacKenzie, G</creatorcontrib><creatorcontrib>Shell, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leichman, L</au><au>Steiger, Z</au><au>Seydel, H G</au><au>Dindogru, A</au><au>Kinzie, J</au><au>Toben, S</au><au>MacKenzie, G</au><au>Shell, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative chemotherapy and radiation therapy for patients with cancer of the esophagus: a potentially curative approach</atitle><jtitle>Journal of clinical oncology</jtitle><addtitle>J Clin Oncol</addtitle><date>1984-02</date><risdate>1984</risdate><volume>2</volume><issue>2</issue><spage>75</spage><epage>79</epage><pages>75-79</pages><issn>0732-183X</issn><eissn>1527-7755</eissn><abstract>Twenty-one patients with squamous cell cancer of the esophagus were entered into a pilot clinical trial using preoperative chemotherapy (5-fluorouracil and cis-platinum) and radiation with the intent of improving cure rate and survival. After the preoperative treatment was complete, 15 patients (71%) were resected for cure. Seven (47%) of 15 had no histologic evidence of cancer in the resected esophagus, but two of these had microscopic cancer in resected lymph nodes. The median survival for all patients entered in the trial was 18 months, whereas for those with no cancer in the resected esophagus the median survival was 24 months. The six patients who either refused surgery (two patients) or were unresectable at surgery (four patients) died within nine months. Our conclusion in this trial is that survival and potential cure are clearly linked to successfully clearing the esophagus and nodes of histologic evidence of tumor through preoperative treatment.</abstract><cop>United States</cop><pub>American Society of Clinical Oncology</pub><pmid>6538224</pmid><doi>10.1200/JCO.1984.2.2.75</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0732-183X |
| ispartof | Journal of clinical oncology, 1984-02, Vol.2 (2), p.75-79 |
| issn | 0732-183X 1527-7755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80986626 |
| source | MEDLINE; American Society of Clinical Oncology Online Journals; Journals@Ovid Complete |
| subjects | Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - surgery Cisplatin - administration & dosage Combined Modality Therapy Esophageal Neoplasms - drug therapy Esophageal Neoplasms - mortality Esophageal Neoplasms - radiotherapy Esophageal Neoplasms - surgery Female Fluorouracil - administration & dosage Humans Male Middle Aged |
| title | Preoperative chemotherapy and radiation therapy for patients with cancer of the esophagus: a potentially curative approach |
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