The absolute bioavailability of oral cefuroxime axetil in male and female volunteers after fasting and after food
Cefuroxime axetil is a novel oral cephalosporin. Two studies are described in which fasting male and female volunteers were given single oral doses of 1 g cefuroxime axetil in comparison with intravenous cefuroxime, and in which absorption was compared in the fasting and non-fasting states. The mean...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1984-02, Vol.13 (2), p.191-196 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Williams, Peter E. O. Harding, Stuart M. |
| description | Cefuroxime axetil is a novel oral cephalosporin. Two studies are described in which fasting male and female volunteers were given single oral doses of 1 g cefuroxime axetil in comparison with intravenous cefuroxime, and in which absorption was compared in the fasting and non-fasting states. The mean (and range) absolute bioavailability of cefuroxime axetil in the first study was 0.35 (0.26–0.44) in male volunteers and 0.32 (0.23–0.41) in female volunteers. In the second study, the bioavailability was significantly greater when cefuroxime axetil was given after food: 0.45 (0.34–0.55) in males and 0.41 (0.29–0.51) in females. There were no differences between the pharmacokinetics of cefuroxime axetil in males and females. It is recommended that patients take doses of cefuroxime axetil shortly after food. |
| doi_str_mv | 10.1093/jac/13.2.191 |
| format | Article |
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O. ; Harding, Stuart M.</creator><creatorcontrib>Williams, Peter E. O. ; Harding, Stuart M.</creatorcontrib><description>Cefuroxime axetil is a novel oral cephalosporin. Two studies are described in which fasting male and female volunteers were given single oral doses of 1 g cefuroxime axetil in comparison with intravenous cefuroxime, and in which absorption was compared in the fasting and non-fasting states. The mean (and range) absolute bioavailability of cefuroxime axetil in the first study was 0.35 (0.26–0.44) in male volunteers and 0.32 (0.23–0.41) in female volunteers. In the second study, the bioavailability was significantly greater when cefuroxime axetil was given after food: 0.45 (0.34–0.55) in males and 0.41 (0.29–0.51) in females. There were no differences between the pharmacokinetics of cefuroxime axetil in males and females. It is recommended that patients take doses of cefuroxime axetil shortly after food.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/13.2.191</identifier><identifier>PMID: 6706890</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Administration, Oral ; Adult ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Biological Availability ; Cefuroxime - administration & dosage ; Cefuroxime - metabolism ; Cephalosporins - metabolism ; Fasting ; Female ; Food ; Humans ; Injections, Intravenous ; Kinetics ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Random Allocation ; Sex Factors</subject><ispartof>Journal of antimicrobial chemotherapy, 1984-02, Vol.13 (2), p.191-196</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-87b2cc99eb83214b717a73c9703a8662d944011298e7104fbefc985db9ee91fa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9465049$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6706890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, Peter E. O.</creatorcontrib><creatorcontrib>Harding, Stuart M.</creatorcontrib><title>The absolute bioavailability of oral cefuroxime axetil in male and female volunteers after fasting and after food</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>Cefuroxime axetil is a novel oral cephalosporin. Two studies are described in which fasting male and female volunteers were given single oral doses of 1 g cefuroxime axetil in comparison with intravenous cefuroxime, and in which absorption was compared in the fasting and non-fasting states. The mean (and range) absolute bioavailability of cefuroxime axetil in the first study was 0.35 (0.26–0.44) in male volunteers and 0.32 (0.23–0.41) in female volunteers. In the second study, the bioavailability was significantly greater when cefuroxime axetil was given after food: 0.45 (0.34–0.55) in males and 0.41 (0.29–0.51) in females. There were no differences between the pharmacokinetics of cefuroxime axetil in males and females. It is recommended that patients take doses of cefuroxime axetil shortly after food.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Cefuroxime - administration & dosage</subject><subject>Cefuroxime - metabolism</subject><subject>Cephalosporins - metabolism</subject><subject>Fasting</subject><subject>Female</subject><subject>Food</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Random Allocation</subject><subject>Sex Factors</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90M9vFCEcBXBiNHWt3ryacDCenC0MDAxH01RX0-jBNTFeCMN8USoztMA02_9e7E72xI_3yTs8hF5TsqVEsYsbYy8o27ZbqugTtKFckKYlij5FG8JI10jesefoRc43hBDRif4MnQlJRK_IBt3t_wA2Q45hKYAHH8298cEMPvjygKPDMZmALbglxYOfqj1A8QH7GU8m1Oc8YgeP1_vaMReAlLFxBRJ2Jhc__34060-M40v0zJmQ4dV6nqMfH6_2l7vm-tunz5cfrhvLqSpNL4fWWqVg6FlL-SCpNJJZJQkzvRDtqDgnlLaqB0kJdwM4q_puHBSAos6wc_Tu2Hub4t0CuejJZwshmBniknVPVM8FkxW-P0KbYs4JnL5NfjLpQVOi_y-s68KaMt3qunDlb9beZZhgPOF10pq_XXOTrQkumdn6fGKKi45wVVlzZD4XOJxik_7WJiY7vfv5SzPx5ftO0K96z_4BYBWT0Q</recordid><startdate>198402</startdate><enddate>198402</enddate><creator>Williams, Peter E. O.</creator><creator>Harding, Stuart M.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198402</creationdate><title>The absolute bioavailability of oral cefuroxime axetil in male and female volunteers after fasting and after food</title><author>Williams, Peter E. O. ; Harding, Stuart M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-87b2cc99eb83214b717a73c9703a8662d944011298e7104fbefc985db9ee91fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Cefuroxime - administration & dosage</topic><topic>Cefuroxime - metabolism</topic><topic>Cephalosporins - metabolism</topic><topic>Fasting</topic><topic>Female</topic><topic>Food</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Random Allocation</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, Peter E. O.</creatorcontrib><creatorcontrib>Harding, Stuart M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, Peter E. O.</au><au>Harding, Stuart M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The absolute bioavailability of oral cefuroxime axetil in male and female volunteers after fasting and after food</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1984-02</date><risdate>1984</risdate><volume>13</volume><issue>2</issue><spage>191</spage><epage>196</epage><pages>191-196</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>Cefuroxime axetil is a novel oral cephalosporin. Two studies are described in which fasting male and female volunteers were given single oral doses of 1 g cefuroxime axetil in comparison with intravenous cefuroxime, and in which absorption was compared in the fasting and non-fasting states. The mean (and range) absolute bioavailability of cefuroxime axetil in the first study was 0.35 (0.26–0.44) in male volunteers and 0.32 (0.23–0.41) in female volunteers. In the second study, the bioavailability was significantly greater when cefuroxime axetil was given after food: 0.45 (0.34–0.55) in males and 0.41 (0.29–0.51) in females. There were no differences between the pharmacokinetics of cefuroxime axetil in males and females. It is recommended that patients take doses of cefuroxime axetil shortly after food.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>6706890</pmid><doi>10.1093/jac/13.2.191</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of antimicrobial chemotherapy, 1984-02, Vol.13 (2), p.191-196 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Administration, Oral Adult Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Biological Availability Cefuroxime - administration & dosage Cefuroxime - metabolism Cephalosporins - metabolism Fasting Female Food Humans Injections, Intravenous Kinetics Male Medical sciences Pharmacology. Drug treatments Random Allocation Sex Factors |
| title | The absolute bioavailability of oral cefuroxime axetil in male and female volunteers after fasting and after food |
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