Tri- and tetrapeptide analogs of kinins as potential renal vasodilators

Tri- and tetrapeptide analogues were synthesized and evaluated as renal vasodilators. These peptides were prepared by standard coupling reactions, which also provided good yields with hindered alpha-methyl amino acid derivatives. Preliminary evidence of renal vasodilator activity was determined in a...

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Veröffentlicht in:	Journal of medicinal chemistry 1984-03, Vol.27 (3), p.325-341
Hauptverfasser:	Pfeiffer, Francis R, Chambers, Pamela A, Hilbert, Eileen E, Woodward, Paul W, Ackerman, Dennis M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bradykinin - analogs & derivatives Bradykinin - pharmacology Dogs kidney Kidney - blood supply kinins Peptide Fragments - pharmacology peptide synthesis Regional Blood Flow - drug effects Structure-Activity Relationship Vascular Resistance - drug effects Vasodilator Agents - chemical synthesis Vasodilator Agents - pharmacology vasodilators
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