Cushing's Disease and Basophilic Microadenomas
An editorial appearing six years ago in the Journal 1 pointed out the unresolved controversy between those who considered Cushing's disease to be the result of a primary neoplastic change of the pituitary corticotrope cells and those who believed that the primary disease lay within the hypothal...
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| Veröffentlicht in: | The New England journal of medicine 1984-04, Vol.310 (14), p.919-920 |
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| container_issue | 14 |
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| container_title | The New England journal of medicine |
| container_volume | 310 |
| creator | Daughaday, William H |
| description | An editorial appearing six years ago in the
Journal
1
pointed out the unresolved controversy between those who considered Cushing's disease to be the result of a primary neoplastic change of the pituitary corticotrope cells and those who believed that the primary disease lay within the hypothalamus and that pituitary corticotrope tumors resulted from chronic overstimulation of corticotrope cells. Physicians belonging to the first camp favored transsphenoidal microsurgery with removal of what was considered the primary cause of the condition. Physicians of the second camp sought medications that would restore hypothalamic function. In a minority of cases cyproheptadine seemed to achieve . . . |
| doi_str_mv | 10.1056/NEJM198404053101411 |
| format | Article |
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pointed out the unresolved controversy between those who considered Cushing's disease to be the result of a primary neoplastic change of the pituitary corticotrope cells and those who believed that the primary disease lay within the hypothalamus and that pituitary corticotrope tumors resulted from chronic overstimulation of corticotrope cells. Physicians belonging to the first camp favored transsphenoidal microsurgery with removal of what was considered the primary cause of the condition. Physicians of the second camp sought medications that would restore hypothalamic function. In a minority of cases cyproheptadine seemed to achieve . . .</description><subject>Adenoma - physiopathology</subject><subject>Adenoma - therapy</subject><subject>Adrenocorticotropic hormone</subject><subject>Adrenocorticotropic Hormone - secretion</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Child</subject><subject>Corticotropin-Releasing Hormone - pharmacology</subject><subject>Cushing Syndrome - physiopathology</subject><subject>Cushing Syndrome - therapy</subject><subject>Cushing Syndrome - veterinary</subject><subject>Disease Models, Animal</subject><subject>Endorphins</subject><subject>Hormones</subject><subject>Horse Diseases - physiopathology</subject><subject>Horses</subject><subject>Humans</subject><subject>Nervous system diseases</subject><subject>Patients</subject><subject>Peptides</subject><subject>Pituitary</subject><subject>Pituitary Neoplasms - physiopathology</subject><subject>Pituitary Neoplasms - therapy</subject><subject>Radiation therapy</subject><subject>Tumors</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kEtPwzAQhC0EKqXwCxBSJCQ4oJRdPxL7WEp5qYULnC3HcWiqPErcHPj3GLXigBB72cN8M9odQk4RxggiuX6ePS1QSQ4cBENAjrhHhigYizmHZJ8MAaiMearYITnyfgVhkKsBGSSMBqcakvG098uyeb_00W3pnfEuMk0e3RjfrpdlVdpoUdquNblr2tr4Y3JQmMq7k90ekbe72ev0IZ6_3D9OJ_PYsoRvYsSMZZlRgtpCYEqtZCZzFDJh0SQFFEraPC1yJg1wwYAKllvhcoFSWSUEG5GLbe66az965ze6Lr11VWUa1_ZeS1ASuaABPP8Frtq-a8JtGmWagKQMMVBsS4VXvO9codddWZvuUyPo7y71H10G19kuu89ql_94duUF_Wqr17XXjVvV_6Z9AdRFeI0</recordid><startdate>19840405</startdate><enddate>19840405</enddate><creator>Daughaday, William H</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19840405</creationdate><title>Cushing's Disease and Basophilic Microadenomas</title><author>Daughaday, William H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-11b3bba952cf5172c83abe20b5c1a6f0f98cd7fd38a04530253dc5ed5189c9553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adenoma - physiopathology</topic><topic>Adenoma - therapy</topic><topic>Adrenocorticotropic hormone</topic><topic>Adrenocorticotropic Hormone - secretion</topic><topic>Animal behavior</topic><topic>Animals</topic><topic>Child</topic><topic>Corticotropin-Releasing Hormone - pharmacology</topic><topic>Cushing Syndrome - physiopathology</topic><topic>Cushing Syndrome - therapy</topic><topic>Cushing Syndrome - veterinary</topic><topic>Disease Models, Animal</topic><topic>Endorphins</topic><topic>Hormones</topic><topic>Horse Diseases - physiopathology</topic><topic>Horses</topic><topic>Humans</topic><topic>Nervous system diseases</topic><topic>Patients</topic><topic>Peptides</topic><topic>Pituitary</topic><topic>Pituitary Neoplasms - physiopathology</topic><topic>Pituitary Neoplasms - therapy</topic><topic>Radiation therapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daughaday, William H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest Research Library</collection><collection>Science Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daughaday, William H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cushing's Disease and Basophilic Microadenomas</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1984-04-05</date><risdate>1984</risdate><volume>310</volume><issue>14</issue><spage>919</spage><epage>920</epage><pages>919-920</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>An editorial appearing six years ago in the
Journal
1
pointed out the unresolved controversy between those who considered Cushing's disease to be the result of a primary neoplastic change of the pituitary corticotrope cells and those who believed that the primary disease lay within the hypothalamus and that pituitary corticotrope tumors resulted from chronic overstimulation of corticotrope cells. Physicians belonging to the first camp favored transsphenoidal microsurgery with removal of what was considered the primary cause of the condition. Physicians of the second camp sought medications that would restore hypothalamic function. In a minority of cases cyproheptadine seemed to achieve . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>6321989</pmid><doi>10.1056/NEJM198404053101411</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1984-04, Vol.310 (14), p.919-920 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80981452 |
| source | MEDLINE; ProQuest Central |
| subjects | Adenoma - physiopathology Adenoma - therapy Adrenocorticotropic hormone Adrenocorticotropic Hormone - secretion Animal behavior Animals Child Corticotropin-Releasing Hormone - pharmacology Cushing Syndrome - physiopathology Cushing Syndrome - therapy Cushing Syndrome - veterinary Disease Models, Animal Endorphins Hormones Horse Diseases - physiopathology Horses Humans Nervous system diseases Patients Peptides Pituitary Pituitary Neoplasms - physiopathology Pituitary Neoplasms - therapy Radiation therapy Tumors |
| title | Cushing's Disease and Basophilic Microadenomas |
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