A new 111in-bleomycin complex for tumor imaging: Preparation, stability, and distribution in glioma-bearing mice

A new 111In‐bleomycin complex (111In‐BLMC) is here reported. Its radiochemical purity was 99% by thin‐layer chromatography (TLC) (Rf 0.65) and in 5% agarose gel electrophoresis in 0.02 M NaHCO3 it migrated toward the anode. Autoradiographs of TLC and gel electrophoresis plates showed no change on st...

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Veröffentlicht in:	J. Surg. Oncol.; (United States) 1984-03, Vol.25 (3), p.168-175
Hauptverfasser:	Hou, De-Yan, Hoch, Hans, Johnston, Gerald S., Tsou, K. C., Jones, Alfred E., Farkas, Raymond J., Miller, Elizabeth E.
Format:	Artikel
Sprache:	eng
Schlagworte:	400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials 560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987) ANIMALS ANTI-INFECTIVE AGENTS ANTIBIOTICS ANTIMITOTIC DRUGS ANTINEOPLASTIC DRUGS AUTORADIOGRAPHY BETA DECAY RADIOISOTOPES BLEOMYCIN Bleomycin - analysis CHEMICAL PREPARATION CHEMISTRY CHROMATOGRAPHY Chromatography, Thin Layer DAYS LIVING RADIOISOTOPES DISEASES DISTRIBUTION DRUGS ELECTRON CAPTURE RADIOISOTOPES ELECTROPHORESIS Glioma - diagnostic imaging Indium - analysis INDIUM 111 INDIUM ISOTOPES INTERMEDIATE MASS NUCLEI ISOMERIC TRANSITION ISOTOPES ISOTOPES Kinetics LABELLED COMPOUNDS LABELLING Male MAMMALS MICE Mice, Inbred C57BL MINUTES LIVING RADIOISOTOPES NEOPLASMS new 111In-bleomycin complex NUCLEI ODD-EVEN NUCLEI RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOCHEMISTRY RADIOISOTOPES Radioisotopes - analysis Radionuclide Imaging RADIOPHARMACEUTICALS RODENTS SEPARATION PROCESSES STABILITY SYNTHESIS THIN-LAYER CHROMATOGRAPHY TISSUE DISTRIBUTION tumor imaging VERTEBRATES
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