The Pathophysiology of Ovine Ostertagiasis: a Study of the Changes in Plasma Protein Metabolism Following Single Infections
Using 125I-albumin and 51CrCl3 plasma albumin turnover rates and plasma loss into the gastrointestinal tract were measured concurrently for 5 weeks following injection of sheep with 300,000–900,000 O. circumcincta larvae as single infections. Only in the heavier infection were inappetence and diarrh...
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| Veröffentlicht in: | Research in veterinary science 1971-05, Vol.12 (3), p.265-271 |
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| creator | Holmes, P.H. MacLean, J.M. |
| description | Using 125I-albumin and 51CrCl3 plasma albumin turnover rates and plasma loss into the gastrointestinal tract were measured concurrently for 5 weeks following injection of sheep with 300,000–900,000 O. circumcincta larvae as single infections. Only in the heavier infection were inappetence and diarrhoea noted and these were of a transient nature. Between Days 5 and 9 a marked rise in plasma loss and plasma pepsinogen values were detected and these were associated with a greatly increased turnover rate of albumin. Both the plasma leak and albumin hypercatabolism showed a progressive decline between Days 14 and 22 while the plasma pepsinogen values remained elevated. Despite the significant plasma loss the serum albumin concentrations were not greatly decreased. |
| doi_str_mv | 10.1016/S0034-5288(18)34189-4 |
| format | Article |
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Only in the heavier infection were inappetence and diarrhoea noted and these were of a transient nature. Between Days 5 and 9 a marked rise in plasma loss and plasma pepsinogen values were detected and these were associated with a greatly increased turnover rate of albumin. Both the plasma leak and albumin hypercatabolism showed a progressive decline between Days 14 and 22 while the plasma pepsinogen values remained elevated. Despite the significant plasma loss the serum albumin concentrations were not greatly decreased.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/S0034-5288(18)34189-4</identifier><identifier>PMID: 4930249</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Albumin ; animal diseases ; animal health ; Animals ; Appetite loss ; Blood Proteins - metabolism ; Chromium Isotopes ; Diarrhea ; Enzyme Precursors - blood ; Gastrointestinal system ; Gastrointestinal tract ; Hematocrit ; Infections ; Intestines - metabolism ; Larvae ; Male ; Metabolism ; Pepsin A - blood ; Plasma ; Plasma loss ; Protein metabolism ; Protein turnover ; Proteins ; Serum albumin ; Serum Albumin, Radio-Iodinated - metabolism ; Sheep ; Sheep Diseases - metabolism ; Trichostrongyloidiasis - metabolism ; Trichostrongyloidiasis - veterinary ; Turnover rate ; Veterinary medicine</subject><ispartof>Research in veterinary science, 1971-05, Vol.12 (3), p.265-271</ispartof><rights>1971</rights><rights>Copyright Elsevier Limited May 1971</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-1b4cd70de2ffec48550bdfc08c27c531d6f154ebe9424d006fae0afb5d059c613</citedby><cites>FETCH-LOGICAL-c327t-1b4cd70de2ffec48550bdfc08c27c531d6f154ebe9424d006fae0afb5d059c613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0034-5288(18)34189-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4930249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holmes, P.H.</creatorcontrib><creatorcontrib>MacLean, J.M.</creatorcontrib><title>The Pathophysiology of Ovine Ostertagiasis: a Study of the Changes in Plasma Protein Metabolism Following Single Infections</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>Using 125I-albumin and 51CrCl3 plasma albumin turnover rates and plasma loss into the gastrointestinal tract were measured concurrently for 5 weeks following injection of sheep with 300,000–900,000 O. circumcincta larvae as single infections. Only in the heavier infection were inappetence and diarrhoea noted and these were of a transient nature. Between Days 5 and 9 a marked rise in plasma loss and plasma pepsinogen values were detected and these were associated with a greatly increased turnover rate of albumin. Both the plasma leak and albumin hypercatabolism showed a progressive decline between Days 14 and 22 while the plasma pepsinogen values remained elevated. Despite the significant plasma loss the serum albumin concentrations were not greatly decreased.</description><subject>Albumin</subject><subject>animal diseases</subject><subject>animal health</subject><subject>Animals</subject><subject>Appetite loss</subject><subject>Blood Proteins - metabolism</subject><subject>Chromium Isotopes</subject><subject>Diarrhea</subject><subject>Enzyme Precursors - blood</subject><subject>Gastrointestinal system</subject><subject>Gastrointestinal tract</subject><subject>Hematocrit</subject><subject>Infections</subject><subject>Intestines - metabolism</subject><subject>Larvae</subject><subject>Male</subject><subject>Metabolism</subject><subject>Pepsin A - blood</subject><subject>Plasma</subject><subject>Plasma loss</subject><subject>Protein metabolism</subject><subject>Protein turnover</subject><subject>Proteins</subject><subject>Serum albumin</subject><subject>Serum Albumin, Radio-Iodinated - metabolism</subject><subject>Sheep</subject><subject>Sheep Diseases - metabolism</subject><subject>Trichostrongyloidiasis - metabolism</subject><subject>Trichostrongyloidiasis - veterinary</subject><subject>Turnover rate</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxQdR6lr9CMWAIPVhNMkkMxlfRBarhcoubPscMsnNbMrsZJtkWha_vNk_9MEXX3IJ53cul3OK4oLgzwST-ssK44qVnApxScSnihHRluxFMSO8oiWta_KymD0jr4s3Md5jjBkhzVlxxtoKU9bOij-3a0BLldZ-u95F5wff75C3aPHoRkCLmCAk1TsVXfyKFFqlyRz0lG3ztRp7iMiNaDmouFFoGXyC_P0NSXV-cHGDrvww-Cc39miVnwHQ9WhBJ-fH-LZ4ZdUQ4d1pnhd3Vz9u57_Km8XP6_n3m1JXtEkl6Zg2DTZAbXYywTnujNVYaNpoXhFTW8IZdNAyygzGtVWAle24wbzVNanOi4_HvdvgHyaISW5c1DAMagQ_RSlw23AmWAY__APe-ymM-TZJCRMtbnO2meJHSgcfYwArt8FtVNhJguW-GnmoRu5zl0TIQzVyv_3itH3qNmCeXacusv7-qFvlpeqDi_JuRTGpMCFVzWmdiW9HAnJajw6CjNrBqMG4kDOVxrv_3PAXBJCoTw</recordid><startdate>197105</startdate><enddate>197105</enddate><creator>Holmes, P.H.</creator><creator>MacLean, J.M.</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>197105</creationdate><title>The Pathophysiology of Ovine Ostertagiasis: a Study of the Changes in Plasma Protein Metabolism Following Single Infections</title><author>Holmes, P.H. ; MacLean, J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-1b4cd70de2ffec48550bdfc08c27c531d6f154ebe9424d006fae0afb5d059c613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Albumin</topic><topic>animal diseases</topic><topic>animal health</topic><topic>Animals</topic><topic>Appetite loss</topic><topic>Blood Proteins - metabolism</topic><topic>Chromium Isotopes</topic><topic>Diarrhea</topic><topic>Enzyme Precursors - blood</topic><topic>Gastrointestinal system</topic><topic>Gastrointestinal tract</topic><topic>Hematocrit</topic><topic>Infections</topic><topic>Intestines - metabolism</topic><topic>Larvae</topic><topic>Male</topic><topic>Metabolism</topic><topic>Pepsin A - blood</topic><topic>Plasma</topic><topic>Plasma loss</topic><topic>Protein metabolism</topic><topic>Protein turnover</topic><topic>Proteins</topic><topic>Serum albumin</topic><topic>Serum Albumin, Radio-Iodinated - metabolism</topic><topic>Sheep</topic><topic>Sheep Diseases - metabolism</topic><topic>Trichostrongyloidiasis - metabolism</topic><topic>Trichostrongyloidiasis - veterinary</topic><topic>Turnover rate</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holmes, P.H.</creatorcontrib><creatorcontrib>MacLean, J.M.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holmes, P.H.</au><au>MacLean, J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Pathophysiology of Ovine Ostertagiasis: a Study of the Changes in Plasma Protein Metabolism Following Single Infections</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>1971-05</date><risdate>1971</risdate><volume>12</volume><issue>3</issue><spage>265</spage><epage>271</epage><pages>265-271</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>Using 125I-albumin and 51CrCl3 plasma albumin turnover rates and plasma loss into the gastrointestinal tract were measured concurrently for 5 weeks following injection of sheep with 300,000–900,000 O. circumcincta larvae as single infections. Only in the heavier infection were inappetence and diarrhoea noted and these were of a transient nature. Between Days 5 and 9 a marked rise in plasma loss and plasma pepsinogen values were detected and these were associated with a greatly increased turnover rate of albumin. Both the plasma leak and albumin hypercatabolism showed a progressive decline between Days 14 and 22 while the plasma pepsinogen values remained elevated. Despite the significant plasma loss the serum albumin concentrations were not greatly decreased.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>4930249</pmid><doi>10.1016/S0034-5288(18)34189-4</doi><tpages>7</tpages></addata></record> |
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| ispartof | Research in veterinary science, 1971-05, Vol.12 (3), p.265-271 |
| issn | 0034-5288 1532-2661 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Albumin animal diseases animal health Animals Appetite loss Blood Proteins - metabolism Chromium Isotopes Diarrhea Enzyme Precursors - blood Gastrointestinal system Gastrointestinal tract Hematocrit Infections Intestines - metabolism Larvae Male Metabolism Pepsin A - blood Plasma Plasma loss Protein metabolism Protein turnover Proteins Serum albumin Serum Albumin, Radio-Iodinated - metabolism Sheep Sheep Diseases - metabolism Trichostrongyloidiasis - metabolism Trichostrongyloidiasis - veterinary Turnover rate Veterinary medicine |
| title | The Pathophysiology of Ovine Ostertagiasis: a Study of the Changes in Plasma Protein Metabolism Following Single Infections |
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