Rat hepatic 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase: A unique bifunctional enzyme

Fructose 2,6-bisphosphate is a potent allosteric activator of 6-phosphofructo 1-kinase and an inhibitor of fructose 1,6-bisphosphatase. It potentiates the effect of AMP on both enzymes. A great deal of compelling evidence supports the hypothesis that fructose 2,6-bisphosphate plays a key role in the...

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Veröffentlicht in:	Advances in enzyme regulation 1983, Vol.21, p.147,IN7,153,IN9,163-152,IN8,162,IN10,173
Hauptverfasser:	Pilkis, Simon J., Chrisman, Ted, Burgress, Billy, McGrane, Molly, Colosia, Ann, Pilkis, Jo, Claus, Thomas H., Raafat El-Maghrabi, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-phosphofructokinase Adenosine Triphosphate - metabolism Animals Chromatography, Ion Exchange Cyclic AMP - metabolism Diabetes Mellitus, Experimental - metabolism Electrophoresis, Disc fructose-2,6-diphosphate Fructosediphosphates - metabolism Hormones - metabolism Liver - enzymology Multienzyme Complexes - metabolism Phosphofructokinase-2 Phosphoric Monoester Hydrolases - metabolism Phosphorylation Phosphotransferases - metabolism Rats Starvation - metabolism
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