Sleep states attenuate the pressor response to central amygdala stimulation
We examined the cardiovascular response to electrical stimulation of the region of the central nucleus of the amygdala during sleep and waking states in the intact cat. Stimulation for 0.5 s produced a profound pressor response in the awake animal. This response was attenuated by quiet sleep and gre...
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| Veröffentlicht in: | Experimental neurology 1984-03, Vol.83 (3), p.604-617 |
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| container_title | Experimental neurology |
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| creator | Frysinger, R.C. Marks, J.D. Trelease, R.B. Schechtman, V.L. Harper, R.M. |
| description | We examined the cardiovascular response to electrical stimulation of the region of the central nucleus of the amygdala during sleep and waking states in the intact cat. Stimulation for 0.5 s produced a profound pressor response in the awake animal. This response was attenuated by quiet sleep and greatly attenuated during REM sleep. The attenuation was present even when the animal aroused from the sleep state in which the stimulus was delivered. The degree of sinus arrhythmia during the bradycardia associated with the hypertensive phase was greater during waking than during quiet sleep. We speculate that REM sleep entails a “functional dissociation” between forebrain and brain stem systems involved in cardiovascular regulation. |
| doi_str_mv | 10.1016/0014-4886(84)90127-4 |
| format | Article |
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Stimulation for 0.5 s produced a profound pressor response in the awake animal. This response was attenuated by quiet sleep and greatly attenuated during REM sleep. The attenuation was present even when the animal aroused from the sleep state in which the stimulus was delivered. The degree of sinus arrhythmia during the bradycardia associated with the hypertensive phase was greater during waking than during quiet sleep. We speculate that REM sleep entails a “functional dissociation” between forebrain and brain stem systems involved in cardiovascular regulation.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/0014-4886(84)90127-4</identifier><identifier>PMID: 6698161</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Amygdala - physiology ; Animals ; Biological and medical sciences ; Blood Pressure ; Cats ; Cerebral Cortex - physiology ; Electric Stimulation ; Female ; Fundamental and applied biological sciences. Psychology ; Heart - physiology ; Hippocampus - physiology ; Muscles - physiology ; Respiration ; Sleep - physiology ; Sleep, REM - physiology ; Sleep. 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Stimulation for 0.5 s produced a profound pressor response in the awake animal. This response was attenuated by quiet sleep and greatly attenuated during REM sleep. The attenuation was present even when the animal aroused from the sleep state in which the stimulus was delivered. The degree of sinus arrhythmia during the bradycardia associated with the hypertensive phase was greater during waking than during quiet sleep. We speculate that REM sleep entails a “functional dissociation” between forebrain and brain stem systems involved in cardiovascular regulation.</description><subject>Amygdala - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Cats</subject><subject>Cerebral Cortex - physiology</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart - physiology</subject><subject>Hippocampus - physiology</subject><subject>Muscles - physiology</subject><subject>Respiration</subject><subject>Sleep - physiology</subject><subject>Sleep, REM - physiology</subject><subject>Sleep. Vigilance</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Wakefulness - physiology</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVo2GzS_IMGfCglPTgd2bIsXQJlSZuQhR6anMWsPG4V_BVJDuy_j7a77LGnGWaed5Aexj5xuOHA5TcALnKhlLxW4qsGXtS5OGFLDhryQpTwgS2PyBk7D-EFALQo6gVbSKkVl3zJHn93RFMWIkYKGcZIw5zaLP6lbPIUwuizVKZxCGk4ZpaG6LHLsN_-abDDlHT93GF04_CRnbbYBbo81Av2_OPuaXWfr3_9fFh9X-e2VDLmLZTUlihsxYGkJmk3VjdUVBUWAHWpWl1rjla2Eje8IaVAqt2vykbJopLlBfuyvzv58XWmEE3vgqWuw4HGORgFWlZFqRIo9qD1YwieWjN516PfGg5m59DsBJmdIKOE-efQiBS7OtyfNz01x9BBWtp_PuwxWOxaj4N14YhpqbVWdcJu9xglF2-OvAnW0WCpcZ5sNM3o_v-Od8yWjWM</recordid><startdate>198403</startdate><enddate>198403</enddate><creator>Frysinger, R.C.</creator><creator>Marks, J.D.</creator><creator>Trelease, R.B.</creator><creator>Schechtman, V.L.</creator><creator>Harper, R.M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198403</creationdate><title>Sleep states attenuate the pressor response to central amygdala stimulation</title><author>Frysinger, R.C. ; Marks, J.D. ; Trelease, R.B. ; Schechtman, V.L. ; Harper, R.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f03ef3a4c510e69e6cbc9de255a200738f9791ac6f6ab1de8806810903d862563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Amygdala - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Cats</topic><topic>Cerebral Cortex - physiology</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart - physiology</topic><topic>Hippocampus - physiology</topic><topic>Muscles - physiology</topic><topic>Respiration</topic><topic>Sleep - physiology</topic><topic>Sleep, REM - physiology</topic><topic>Sleep. Vigilance</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Wakefulness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frysinger, R.C.</creatorcontrib><creatorcontrib>Marks, J.D.</creatorcontrib><creatorcontrib>Trelease, R.B.</creatorcontrib><creatorcontrib>Schechtman, V.L.</creatorcontrib><creatorcontrib>Harper, R.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frysinger, R.C.</au><au>Marks, J.D.</au><au>Trelease, R.B.</au><au>Schechtman, V.L.</au><au>Harper, R.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sleep states attenuate the pressor response to central amygdala stimulation</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>1984-03</date><risdate>1984</risdate><volume>83</volume><issue>3</issue><spage>604</spage><epage>617</epage><pages>604-617</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>We examined the cardiovascular response to electrical stimulation of the region of the central nucleus of the amygdala during sleep and waking states in the intact cat. Stimulation for 0.5 s produced a profound pressor response in the awake animal. This response was attenuated by quiet sleep and greatly attenuated during REM sleep. The attenuation was present even when the animal aroused from the sleep state in which the stimulus was delivered. The degree of sinus arrhythmia during the bradycardia associated with the hypertensive phase was greater during waking than during quiet sleep. We speculate that REM sleep entails a “functional dissociation” between forebrain and brain stem systems involved in cardiovascular regulation.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>6698161</pmid><doi>10.1016/0014-4886(84)90127-4</doi><tpages>14</tpages></addata></record> |
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| ispartof | Experimental neurology, 1984-03, Vol.83 (3), p.604-617 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amygdala - physiology Animals Biological and medical sciences Blood Pressure Cats Cerebral Cortex - physiology Electric Stimulation Female Fundamental and applied biological sciences. Psychology Heart - physiology Hippocampus - physiology Muscles - physiology Respiration Sleep - physiology Sleep, REM - physiology Sleep. Vigilance Vertebrates: nervous system and sense organs Wakefulness - physiology |
| title | Sleep states attenuate the pressor response to central amygdala stimulation |
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