Effects of a gonadotropin-releasing hormone antagonist on hormonal levels in the pregnant baboon and on fetal outcome
In order to study the function of a gonadotropin-releasing hormone (GnRH) in pregnancy, a GnRH antagonist was administered to pregnant baboons (35 to 45days’ gestation) over 7days. A marked suppression of progesterone, estrone, and estradiol was observed during treatment. In two animals, estrogens w...
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| Veröffentlicht in: | Fertility and sterility 1984-03, Vol.41 (3), p.448-454 |
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| container_title | Fertility and sterility |
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| creator | Siler-Khodr, Theresa M. Kuehl, Thomas J. Vickery, Brian H. |
| description | In order to study the function of a gonadotropin-releasing hormone (GnRH) in pregnancy, a GnRH antagonist was administered to pregnant baboons (35 to 45days’ gestation) over 7days. A marked suppression of progesterone, estrone, and estradiol was observed during treatment. In two animals, estrogens were still suppressed later in pregnancy (days 95 to 116), and delivery resulted in stillbirths. In one of these animals the placenta was recovered, and it was half normal size. In the third animal, the circulating steroids, including the estrogens, returned to normal levels following antagonist administration, and a small live-born fetus was delivered.
These data indicate that interference with GnRH activity during early pregnancy can result in stillbirths, possibly due to induction of placental insufficiency. Thus, these studies support the hypothesis that chorionic GnRH has a physiologic function during pregnancy in the control of placental hormonogenesis and normal fetal outcome. |
| doi_str_mv | 10.1016/S0015-0282(16)47726-5 |
| format | Article |
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These data indicate that interference with GnRH activity during early pregnancy can result in stillbirths, possibly due to induction of placental insufficiency. Thus, these studies support the hypothesis that chorionic GnRH has a physiologic function during pregnancy in the control of placental hormonogenesis and normal fetal outcome.</description><subject>Animals</subject><subject>Chorionic Gonadotropin - blood</subject><subject>Estradiol - blood</subject><subject>Estrone - blood</subject><subject>Female</subject><subject>Fetal Death - physiopathology</subject><subject>Fetus - physiology</subject><subject>Gestational Age</subject><subject>Papio</subject><subject>Pituitary Hormone-Releasing Hormones - antagonists & inhibitors</subject><subject>Pituitary Hormone-Releasing Hormones - blood</subject><subject>Pituitary Hormone-Releasing Hormones - physiology</subject><subject>Placenta - physiology</subject><subject>Pregnancy</subject><subject>Progesterone - blood</subject><subject>Radioimmunoassay</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFq3DAQhkVpSLbbPkJAp9Ie3Ei2JdunUkKSFhZySHIWY2m0UbGljSQv5O2rzS659jSa-b_RwEfIJWc_OOPy6oExLipW9_U3Lr-3XVfLSnwgKy5EeUjRfCSrd-SCfErpL2NM8q4-J-eykUKydkWWG2tR50SDpUC3wYMJOYad81XECSE5v6XPIc7BIwWfoSAuZRr8aQoTnXCPU6LO0_yMdBdx6wtJRxhDwcCbA20xFzQsWYcZP5MzC1PCL6e6Jk-3N4_Xv6vN_d2f61-bSrddk6vRtqO0tWkkqwcwYmy1EYZbyVvDOj70sgx1DQas1WM3AA59SRsNmo8a-mZNvh7_3cXwsmDKanZJ4zSBx7Ak1bNBtoNgBRRHUMeQUkSrdtHNEF8VZ-qgW73pVgeXqnRvupUoe5enA8s4o3nfOvkt-c9jXgTh3mFUSTv0Go2LRbsywf3nwj_eU5J4</recordid><startdate>198403</startdate><enddate>198403</enddate><creator>Siler-Khodr, Theresa M.</creator><creator>Kuehl, Thomas J.</creator><creator>Vickery, Brian H.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198403</creationdate><title>Effects of a gonadotropin-releasing hormone antagonist on hormonal levels in the pregnant baboon and on fetal outcome</title><author>Siler-Khodr, Theresa M. ; Kuehl, Thomas J. ; Vickery, Brian H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-bf4b6f2d36029ad5b4cd5d1f614d071986ad5c2adaffcb79ae981f63cac1bca83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Chorionic Gonadotropin - blood</topic><topic>Estradiol - blood</topic><topic>Estrone - blood</topic><topic>Female</topic><topic>Fetal Death - physiopathology</topic><topic>Fetus - physiology</topic><topic>Gestational Age</topic><topic>Papio</topic><topic>Pituitary Hormone-Releasing Hormones - antagonists & inhibitors</topic><topic>Pituitary Hormone-Releasing Hormones - blood</topic><topic>Pituitary Hormone-Releasing Hormones - physiology</topic><topic>Placenta - physiology</topic><topic>Pregnancy</topic><topic>Progesterone - blood</topic><topic>Radioimmunoassay</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siler-Khodr, Theresa M.</creatorcontrib><creatorcontrib>Kuehl, Thomas J.</creatorcontrib><creatorcontrib>Vickery, Brian H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siler-Khodr, Theresa M.</au><au>Kuehl, Thomas J.</au><au>Vickery, Brian H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of a gonadotropin-releasing hormone antagonist on hormonal levels in the pregnant baboon and on fetal outcome</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1984-03</date><risdate>1984</risdate><volume>41</volume><issue>3</issue><spage>448</spage><epage>454</epage><pages>448-454</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>In order to study the function of a gonadotropin-releasing hormone (GnRH) in pregnancy, a GnRH antagonist was administered to pregnant baboons (35 to 45days’ gestation) over 7days. 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These data indicate that interference with GnRH activity during early pregnancy can result in stillbirths, possibly due to induction of placental insufficiency. Thus, these studies support the hypothesis that chorionic GnRH has a physiologic function during pregnancy in the control of placental hormonogenesis and normal fetal outcome.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6365604</pmid><doi>10.1016/S0015-0282(16)47726-5</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 1984-03, Vol.41 (3), p.448-454 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Chorionic Gonadotropin - blood Estradiol - blood Estrone - blood Female Fetal Death - physiopathology Fetus - physiology Gestational Age Papio Pituitary Hormone-Releasing Hormones - antagonists & inhibitors Pituitary Hormone-Releasing Hormones - blood Pituitary Hormone-Releasing Hormones - physiology Placenta - physiology Pregnancy Progesterone - blood Radioimmunoassay |
| title | Effects of a gonadotropin-releasing hormone antagonist on hormonal levels in the pregnant baboon and on fetal outcome |
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