The pattern of the mononuclear infiltrate as a prognostic parameter in flat superficial spreading melanomas
The mononuclear cell infiltrate of 90 superficial spreading melanomas (SSM) of less than or equal to 1.5 mm thickness was analyzed at different locations around and within the tumors. All patients had been followed for at least 5 years, and 20 (22%) had developed metastases. A correlation between th...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 1984-01, Vol.107 (1), p.48-52 |
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| container_title | Journal of cancer research and clinical oncology |
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| creator | BRÖCKER, E.-B KOLDE, G STEINHAUSEN, D PETERS, A MACHER, E |
| description | The mononuclear cell infiltrate of 90 superficial spreading melanomas (SSM) of less than or equal to 1.5 mm thickness was analyzed at different locations around and within the tumors. All patients had been followed for at least 5 years, and 20 (22%) had developed metastases. A correlation between the overall inflammatory response in the histologic sections and the prognosis was not observed, nor could a significant distinction be made between metastasizing and nonmetastasizing melanomas when the mononuclear cell infiltrate was analyzed at different locations. A significant clustering of metastasizing tumors was, however, observed in the subgroup with a relatively strong infiltrate within the tumor compared with the overall infiltrate. From this observation, a semiquantitative description of the pattern of the infiltrate was established. It provides an additional parameter for prognostication in flat SSMs and it raises new questions about the role of the local host-tumor interaction. |
| doi_str_mv | 10.1007/BF00395490 |
| format | Article |
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All patients had been followed for at least 5 years, and 20 (22%) had developed metastases. A correlation between the overall inflammatory response in the histologic sections and the prognosis was not observed, nor could a significant distinction be made between metastasizing and nonmetastasizing melanomas when the mononuclear cell infiltrate was analyzed at different locations. A significant clustering of metastasizing tumors was, however, observed in the subgroup with a relatively strong infiltrate within the tumor compared with the overall infiltrate. From this observation, a semiquantitative description of the pattern of the infiltrate was established. It provides an additional parameter for prognostication in flat SSMs and it raises new questions about the role of the local host-tumor interaction.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/BF00395490</identifier><identifier>PMID: 6699074</identifier><identifier>CODEN: JCROD7</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Biological and medical sciences ; Cell Movement ; Dermatology ; Female ; Humans ; Inflammation - immunology ; Male ; Medical sciences ; Melanoma - immunology ; Melanoma - pathology ; Melanoma - secondary ; Middle Aged ; Monocytes - immunology ; Prognosis ; Retrospective Studies ; Skin Neoplasms - immunology ; Skin Neoplasms - pathology ; Skin Neoplasms - secondary ; Time Factors ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Journal of cancer research and clinical oncology, 1984-01, Vol.107 (1), p.48-52</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-39755cc0eb3b3e0564ea93e47952da73bac6300ac60c5b05017342431f2be3c83</citedby><cites>FETCH-LOGICAL-c311t-39755cc0eb3b3e0564ea93e47952da73bac6300ac60c5b05017342431f2be3c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9551764$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6699074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BRÖCKER, E.-B</creatorcontrib><creatorcontrib>KOLDE, G</creatorcontrib><creatorcontrib>STEINHAUSEN, D</creatorcontrib><creatorcontrib>PETERS, A</creatorcontrib><creatorcontrib>MACHER, E</creatorcontrib><title>The pattern of the mononuclear infiltrate as a prognostic parameter in flat superficial spreading melanomas</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><description>The mononuclear cell infiltrate of 90 superficial spreading melanomas (SSM) of less than or equal to 1.5 mm thickness was analyzed at different locations around and within the tumors. All patients had been followed for at least 5 years, and 20 (22%) had developed metastases. A correlation between the overall inflammatory response in the histologic sections and the prognosis was not observed, nor could a significant distinction be made between metastasizing and nonmetastasizing melanomas when the mononuclear cell infiltrate was analyzed at different locations. A significant clustering of metastasizing tumors was, however, observed in the subgroup with a relatively strong infiltrate within the tumor compared with the overall infiltrate. From this observation, a semiquantitative description of the pattern of the infiltrate was established. It provides an additional parameter for prognostication in flat SSMs and it raises new questions about the role of the local host-tumor interaction.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cell Movement</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma - immunology</subject><subject>Melanoma - pathology</subject><subject>Melanoma - secondary</subject><subject>Middle Aged</subject><subject>Monocytes - immunology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Skin Neoplasms - immunology</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - secondary</subject><subject>Time Factors</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAQhi0EKqWwsCN5QAxIgXMcx_UIiAISEkuZo4t7AUO-sJ2Bf48RVVnudHqf-3oZOxVwJQD09e0KQBpVGNhjc1HIPBNSqn02B6FFpnJRHrKjED4g1UrnMzYrS2NAF3P2uX4nPmKM5Hs-NDymshv6oZ9sS-i56xvXRo-ROAaOfPTDWz-E6Gzq8thRakwQb1qMPEwj-cZZhy0PoyfcuP6Nd9RiP3QYjtlBg22gk21esNfV_fruMXt-eXi6u3nOrBQiZtJopawFqmUtCVRZEBpJhTYq36CWNdpSAqQIVtWg0lOyyAspmrwmaZdywS7-5qZjvyYKsepcsNSmM2iYQrUEUxZSiwRe_oHWDyF4aqrRuw79dyWg-nW2-nc2wWfbqVPd0WaHbq1M-vlWx2CxbTz21oUdZpQSOq39ATasgKA</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>BRÖCKER, E.-B</creator><creator>KOLDE, G</creator><creator>STEINHAUSEN, D</creator><creator>PETERS, A</creator><creator>MACHER, E</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>The pattern of the mononuclear infiltrate as a prognostic parameter in flat superficial spreading melanomas</title><author>BRÖCKER, E.-B ; KOLDE, G ; STEINHAUSEN, D ; PETERS, A ; MACHER, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-39755cc0eb3b3e0564ea93e47952da73bac6300ac60c5b05017342431f2be3c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cell Movement</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma - immunology</topic><topic>Melanoma - pathology</topic><topic>Melanoma - secondary</topic><topic>Middle Aged</topic><topic>Monocytes - immunology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Skin Neoplasms - immunology</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - secondary</topic><topic>Time Factors</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BRÖCKER, E.-B</creatorcontrib><creatorcontrib>KOLDE, G</creatorcontrib><creatorcontrib>STEINHAUSEN, D</creatorcontrib><creatorcontrib>PETERS, A</creatorcontrib><creatorcontrib>MACHER, E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BRÖCKER, E.-B</au><au>KOLDE, G</au><au>STEINHAUSEN, D</au><au>PETERS, A</au><au>MACHER, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pattern of the mononuclear infiltrate as a prognostic parameter in flat superficial spreading melanomas</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>107</volume><issue>1</issue><spage>48</spage><epage>52</epage><pages>48-52</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><coden>JCROD7</coden><abstract>The mononuclear cell infiltrate of 90 superficial spreading melanomas (SSM) of less than or equal to 1.5 mm thickness was analyzed at different locations around and within the tumors. All patients had been followed for at least 5 years, and 20 (22%) had developed metastases. A correlation between the overall inflammatory response in the histologic sections and the prognosis was not observed, nor could a significant distinction be made between metastasizing and nonmetastasizing melanomas when the mononuclear cell infiltrate was analyzed at different locations. A significant clustering of metastasizing tumors was, however, observed in the subgroup with a relatively strong infiltrate within the tumor compared with the overall infiltrate. From this observation, a semiquantitative description of the pattern of the infiltrate was established. It provides an additional parameter for prognostication in flat SSMs and it raises new questions about the role of the local host-tumor interaction.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>6699074</pmid><doi>10.1007/BF00395490</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 1984-01, Vol.107 (1), p.48-52 |
| issn | 0171-5216 1432-1335 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Biological and medical sciences Cell Movement Dermatology Female Humans Inflammation - immunology Male Medical sciences Melanoma - immunology Melanoma - pathology Melanoma - secondary Middle Aged Monocytes - immunology Prognosis Retrospective Studies Skin Neoplasms - immunology Skin Neoplasms - pathology Skin Neoplasms - secondary Time Factors Tumors of the skin and soft tissue. Premalignant lesions |
| title | The pattern of the mononuclear infiltrate as a prognostic parameter in flat superficial spreading melanomas |
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