Failure of cyclosporin-A to induce immunological unresponsiveness to nerve allografts
Although some allografts bearing major and minor transplantation antigens can survive after the cessation of immunosuppression with cyclosporin-A (Cy-A), nerve allografts do not. In an attempt to induce immunological unresponsiveness to nerve allografts, we used grafts containing only minor transpla...
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| Veröffentlicht in: | Experimental neurology 1984-01, Vol.83 (3), p.659-663 |
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| container_title | Experimental neurology |
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| creator | Zalewski, Andrew A. Gulati, Adarsh K. |
| description | Although some allografts bearing major and minor transplantation antigens can survive after the cessation of immunosuppression with cyclosporin-A (Cy-A), nerve allografts do not. In an attempt to induce immunological unresponsiveness to nerve allografts, we used grafts containing only minor transplantation antigens and varied the duration of Cy-A therapy from 2 to 12 weeks. Our results demonstrated that nerve allografts survived in rats during Cy-A therapy, but when the drug administration ceased, the allografts were rejected. Other factors besides the degree of histoincompatibility and duration of Cy-A treatment must be involved in determining whether or not unresponsiveness develops to allografts after Cy-A withdrawal. We conclude that nerve allograft immunosuppression generated by Cy-A requires regular administration of the drug. |
| doi_str_mv | 10.1016/0014-4886(84)90134-1 |
| format | Article |
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In an attempt to induce immunological unresponsiveness to nerve allografts, we used grafts containing only minor transplantation antigens and varied the duration of Cy-A therapy from 2 to 12 weeks. Our results demonstrated that nerve allografts survived in rats during Cy-A therapy, but when the drug administration ceased, the allografts were rejected. Other factors besides the degree of histoincompatibility and duration of Cy-A treatment must be involved in determining whether or not unresponsiveness develops to allografts after Cy-A withdrawal. We conclude that nerve allograft immunosuppression generated by Cy-A requires regular administration of the drug.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/0014-4886(84)90134-1</identifier><identifier>PMID: 6607845</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Cyclosporins - pharmacology ; Histocompatibility Antigens - genetics ; Immunomodulators ; Immunosuppression ; Male ; Medical sciences ; Pharmacology. 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In an attempt to induce immunological unresponsiveness to nerve allografts, we used grafts containing only minor transplantation antigens and varied the duration of Cy-A therapy from 2 to 12 weeks. Our results demonstrated that nerve allografts survived in rats during Cy-A therapy, but when the drug administration ceased, the allografts were rejected. Other factors besides the degree of histoincompatibility and duration of Cy-A treatment must be involved in determining whether or not unresponsiveness develops to allografts after Cy-A withdrawal. We conclude that nerve allograft immunosuppression generated by Cy-A requires regular administration of the drug.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cyclosporins - pharmacology</subject><subject>Histocompatibility Antigens - genetics</subject><subject>Immunomodulators</subject><subject>Immunosuppression</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rats, Inbred Lew</subject><subject>Tibial Nerve - drug effects</subject><subject>Tibial Nerve - transplantation</subject><subject>Transplantation, Homologous</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1LxDAQgOEgiq4f_0ChBxE9VCdtmqYXYVn8AsHLeg5pOpFIm6xJu7D_3tZd9ugph3lmCC8hlxTuKVD-AEBZyoTgt4LdVUBzltIDMqNQQZqxHA7JbE9OyGmM3wBQsaw8JsecQylYMSOfz8q2Q8DEm0RvdOvjygfr0nnS-8S6ZtCY2K4bnG_9l9WqTQYXcEQu2jU6jHGCDsMaE9WOJijTx3NyZFQb8WL3npHl89Ny8Zq-f7y8LebvqWaC9qmuy7zkoATNgJlc6Mog57k2BTWKZrREXVSNQFUbLBsQuuZIGWJRMFSZyM_IzfbsKvifAWMvOxs1tq1y6IcoBVQ8z0o6QraFOvgYAxq5CrZTYSMpyCmmnErJqZQUTP7FlNPa1e7-UHfY7Jd29cb59W6u4pjGBOW0jXsmqoxnDEb2uGU4plhbDDJqi05jYwPqXjbe_v-PX8pakcE</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Zalewski, Andrew A.</creator><creator>Gulati, Adarsh K.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Failure of cyclosporin-A to induce immunological unresponsiveness to nerve allografts</title><author>Zalewski, Andrew A. ; Gulati, Adarsh K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-cb73760a81204f38c9fe663cf51fa1217ec59d8eabfe7d08cb6e14ee554ea283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cyclosporins - pharmacology</topic><topic>Histocompatibility Antigens - genetics</topic><topic>Immunomodulators</topic><topic>Immunosuppression</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rats, Inbred Lew</topic><topic>Tibial Nerve - drug effects</topic><topic>Tibial Nerve - transplantation</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zalewski, Andrew A.</creatorcontrib><creatorcontrib>Gulati, Adarsh K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zalewski, Andrew A.</au><au>Gulati, Adarsh K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Failure of cyclosporin-A to induce immunological unresponsiveness to nerve allografts</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>83</volume><issue>3</issue><spage>659</spage><epage>663</epage><pages>659-663</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>Although some allografts bearing major and minor transplantation antigens can survive after the cessation of immunosuppression with cyclosporin-A (Cy-A), nerve allografts do not. In an attempt to induce immunological unresponsiveness to nerve allografts, we used grafts containing only minor transplantation antigens and varied the duration of Cy-A therapy from 2 to 12 weeks. Our results demonstrated that nerve allografts survived in rats during Cy-A therapy, but when the drug administration ceased, the allografts were rejected. Other factors besides the degree of histoincompatibility and duration of Cy-A treatment must be involved in determining whether or not unresponsiveness develops to allografts after Cy-A withdrawal. We conclude that nerve allograft immunosuppression generated by Cy-A requires regular administration of the drug.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>6607845</pmid><doi>10.1016/0014-4886(84)90134-1</doi><tpages>5</tpages></addata></record> |
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| ispartof | Experimental neurology, 1984-01, Vol.83 (3), p.659-663 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Cyclosporins - pharmacology Histocompatibility Antigens - genetics Immunomodulators Immunosuppression Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred F344 Rats, Inbred Lew Tibial Nerve - drug effects Tibial Nerve - transplantation Transplantation, Homologous |
| title | Failure of cyclosporin-A to induce immunological unresponsiveness to nerve allografts |
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