Synthesis and anticonvulsant properties of some 2-Aminoethanesulfonic acid (Taurine) derivatives

A series of 2‐acylaminoethanesulfonamides were synthesized by treating the corresponding sulfonyl chlorides with ammonia, a primary, or a secondary amine. A few compounds displayed marked anti‐convulsant activity in mice when tested for their potency in the maximal electroshock seizure test. The pip...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1984-01, Vol.73 (1), p.106-108
Hauptverfasser:	Andersen, Lars, Sundman, Lars-Olav, Lindèn, Inge-Britt, Kontro, Pirjo, Oja, Simo S.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-aminoethanesul-fonic acid (taurine) derivatives Animals anticonvulsant activity in mice Anticonvulsant agents-potential Anticonvulsant agents–potential, 2‐aminoethanesul‐fonic acid (taurine) derivatives, synthesis Anticonvulsants - chemical synthesis Brain - metabolism Chemistry Electroshock Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Membranes - metabolism Mice Organic chemistry Preparations and properties Sodium - physiology synthesis Synthesis-2-aminoethan-esulfonic acid (taurine) derivatives Synthesis–2‐aminoethan‐esulfonic acid (taurine) derivatives, anticonvulsant activity in mice Taurine - analogs & derivatives Taurine - chemical synthesis Taurine - pharmacology Taurine-synthesis of derivatives Taurine–synthesis of derivatives, anticonvulsant activity in mice
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