Treadmill performance and cardiac function in selected patients with coronary heart disease
To investigate the cardiac determinants of treadmill performance in patients able to exercise to volitional fatigue, 88 patients with coronary heart disease free of angina pectoris were tested. The exercise tests included supine bicycle radionuclide ventriculography, thallium scintigraphy and treadm...
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| Veröffentlicht in: | J. Am. Coll. Cardiol.; (United States) 1984-02, Vol.3 (2), p.253-261 |
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| creator | Dan Mckirnan, M. Sullivan, Michael Jensen, David Froelicher, Victor F. |
| description | To investigate the cardiac determinants of treadmill performance in patients able to exercise to volitional fatigue, 88 patients with coronary heart disease free of angina pectoris were tested. The exercise tests included supine bicycle radionuclide ventriculography, thallium scintigraphy and treadmill testing with expired gas analysis. The number of abnormal Q wave locations, ejection fraction, end-diastolic volume, cardiac output, exercise-induced ST segment depression and thallium scar and ischemia scores were the cardiac variables considered. Rest and exercise ejection fractions were highly correlated to thallium scar score (r = −0.72 to −0.75, p < 0.001), but not to maximal oxygen consumption (r = 0.19 to 0.25, p < 0.05). Fifty-five percent of the variability in predicting treadmill time or estimated maximal oxygen consumption was explained by treadmill test-induced change in heart rate (39%), thallium ischemia score (12%) and cardiac output at rest (4%). The change in heart rate induced by the treadmill test explained only 27% of the variability in measured maximal oxygen consumption.
Myocardial damage predicted ejection fraction at rest and the ability to increase heart rate with treadmill exercise appeared as an essential component of exercise capacity. Exercise capacity was only minimally affected by asymptomatic ischemia and was relatively independent of ventricular function. |
| doi_str_mv | 10.1016/S0735-1097(84)80008-X |
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Myocardial damage predicted ejection fraction at rest and the ability to increase heart rate with treadmill exercise appeared as an essential component of exercise capacity. Exercise capacity was only minimally affected by asymptomatic ischemia and was relatively independent of ventricular function.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/S0735-1097(84)80008-X</identifier><identifier>PMID: 6693616</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>550602 -- Medicine-- External Radiation in Diagnostics-- (1980-) ; 551001 -- Physiological Systems-- Tracer Techniques ; Adult ; Aged ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BIOMEDICAL RADIOGRAPHY ; BODY ; Cardiac Output ; Cardiac Volume ; Cardiology. Vascular system ; CARDIOVASCULAR DISEASES ; CARDIOVASCULAR SYSTEM ; Coronary Disease - diagnosis ; Coronary Disease - physiopathology ; Coronary heart disease ; COUNTING TECHNIQUES ; DIAGNOSTIC TECHNIQUES ; DISEASES ; DYNAMIC FUNCTION STUDIES ; ELEMENTS ; EXERCISE ; Exercise Test ; HEART ; Heart - diagnostic imaging ; Heart Rate ; Humans ; ISCHEMIA ; ISOTOPES ; Male ; Medical sciences ; MEDICINE ; Middle Aged ; Myocardial Contraction ; NONMETALS ; NUCLEAR MEDICINE ; ORGANS ; OXYGEN ; Oxygen Consumption ; PATIENTS ; Physical Exertion ; RADIOISOTOPE SCANNING ; Radioisotopes ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; Radionuclide Imaging ; RESPIRATION ; SCINTISCANNING ; Space life sciences ; Stroke Volume ; Thallium ; THALLIUM ISOTOPES ; VASCULAR DISEASES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</subject><ispartof>J. Am. Coll. Cardiol.; (United States), 1984-02, Vol.3 (2), p.253-261</ispartof><rights>1984 American College of Cardiology Foundation</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-8475b211f82de79aafc2783dd1de07a480d89b0d15fe0a9cab739c6caf2ea4fb3</citedby><cites>FETCH-LOGICAL-c463t-8475b211f82de79aafc2783dd1de07a480d89b0d15fe0a9cab739c6caf2ea4fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0735-1097(84)80008-X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9516802$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6693616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6727567$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Dan Mckirnan, M.</creatorcontrib><creatorcontrib>Sullivan, Michael</creatorcontrib><creatorcontrib>Jensen, David</creatorcontrib><creatorcontrib>Froelicher, Victor F.</creatorcontrib><creatorcontrib>Univ. of California, San Diego</creatorcontrib><title>Treadmill performance and cardiac function in selected patients with coronary heart disease</title><title>J. Am. Coll. Cardiol.; (United States)</title><addtitle>J Am Coll Cardiol</addtitle><description>To investigate the cardiac determinants of treadmill performance in patients able to exercise to volitional fatigue, 88 patients with coronary heart disease free of angina pectoris were tested. The exercise tests included supine bicycle radionuclide ventriculography, thallium scintigraphy and treadmill testing with expired gas analysis. The number of abnormal Q wave locations, ejection fraction, end-diastolic volume, cardiac output, exercise-induced ST segment depression and thallium scar and ischemia scores were the cardiac variables considered. Rest and exercise ejection fractions were highly correlated to thallium scar score (r = −0.72 to −0.75, p < 0.001), but not to maximal oxygen consumption (r = 0.19 to 0.25, p < 0.05). Fifty-five percent of the variability in predicting treadmill time or estimated maximal oxygen consumption was explained by treadmill test-induced change in heart rate (39%), thallium ischemia score (12%) and cardiac output at rest (4%). The change in heart rate induced by the treadmill test explained only 27% of the variability in measured maximal oxygen consumption.
Myocardial damage predicted ejection fraction at rest and the ability to increase heart rate with treadmill exercise appeared as an essential component of exercise capacity. Exercise capacity was only minimally affected by asymptomatic ischemia and was relatively independent of ventricular function.</description><subject>550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)</subject><subject>551001 -- Physiological Systems-- Tracer Techniques</subject><subject>Adult</subject><subject>Aged</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biological and medical sciences</subject><subject>BIOMEDICAL RADIOGRAPHY</subject><subject>BODY</subject><subject>Cardiac Output</subject><subject>Cardiac Volume</subject><subject>Cardiology. Vascular system</subject><subject>CARDIOVASCULAR DISEASES</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>Coronary Disease - diagnosis</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary heart disease</subject><subject>COUNTING TECHNIQUES</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DISEASES</subject><subject>DYNAMIC FUNCTION STUDIES</subject><subject>ELEMENTS</subject><subject>EXERCISE</subject><subject>Exercise Test</subject><subject>HEART</subject><subject>Heart - diagnostic imaging</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>ISCHEMIA</subject><subject>ISOTOPES</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>Myocardial Contraction</subject><subject>NONMETALS</subject><subject>NUCLEAR MEDICINE</subject><subject>ORGANS</subject><subject>OXYGEN</subject><subject>Oxygen Consumption</subject><subject>PATIENTS</subject><subject>Physical Exertion</subject><subject>RADIOISOTOPE SCANNING</subject><subject>Radioisotopes</subject><subject>RADIOLOGY</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide Imaging</subject><subject>RESPIRATION</subject><subject>SCINTISCANNING</subject><subject>Space life sciences</subject><subject>Stroke Volume</subject><subject>Thallium</subject><subject>THALLIUM ISOTOPES</subject><subject>VASCULAR DISEASES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLVDEQRoMoYzv6EwaCiOjianIfeaxEBl8w4MIRBlyEukmFjtybtEla8d-bnm566yqLOpWq7xQhV5y94YyLt9-YHKaOMy1fqfG1Yoyp7u4B2fBpUt0wafmQbM7IY_KklJ-NEYrrC3IhhB4EFxvy4zYjuDUsC91h9imvEC1SiI5ayC6ApX4fbQ0p0hBpwQVtRUd3UAPGWuifULfUppwi5L90i5ArdaEgFHxKHnlYCj47vZfk-8cPt9efu5uvn75cv7_p7CiG2qlRTnPPuVe9Q6kBvO2lGpzjDpmEUTGn9Mwcnzwy0BZmOWgrLPgeYfTzcEmeH_9NpQZTbKhotzbF2FY1QvZyErJBL4_QLqdfeyzVrKFYXBaImPbFKKaHsc1q4HQEbU6lZPRml8PawhnOzMG8uTdvDlqNGs29eXPX-q5OA_bziu7cdVLd6i9OdSgWFp-b6FDOmJ64UKxv2Lsjhs3Y74D5EAjbTVzIhzwuhf8s8g9-RaGU</recordid><startdate>198402</startdate><enddate>198402</enddate><creator>Dan Mckirnan, M.</creator><creator>Sullivan, Michael</creator><creator>Jensen, David</creator><creator>Froelicher, Victor F.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198402</creationdate><title>Treadmill performance and cardiac function in selected patients with coronary heart disease</title><author>Dan Mckirnan, M. ; Sullivan, Michael ; Jensen, David ; Froelicher, Victor F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-8475b211f82de79aafc2783dd1de07a480d89b0d15fe0a9cab739c6caf2ea4fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)</topic><topic>551001 -- Physiological Systems-- Tracer Techniques</topic><topic>Adult</topic><topic>Aged</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biological and medical sciences</topic><topic>BIOMEDICAL RADIOGRAPHY</topic><topic>BODY</topic><topic>Cardiac Output</topic><topic>Cardiac Volume</topic><topic>Cardiology. Vascular system</topic><topic>CARDIOVASCULAR DISEASES</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>Coronary Disease - diagnosis</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary heart disease</topic><topic>COUNTING TECHNIQUES</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DISEASES</topic><topic>DYNAMIC FUNCTION STUDIES</topic><topic>ELEMENTS</topic><topic>EXERCISE</topic><topic>Exercise Test</topic><topic>HEART</topic><topic>Heart - diagnostic imaging</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>ISCHEMIA</topic><topic>ISOTOPES</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>Myocardial Contraction</topic><topic>NONMETALS</topic><topic>NUCLEAR MEDICINE</topic><topic>ORGANS</topic><topic>OXYGEN</topic><topic>Oxygen Consumption</topic><topic>PATIENTS</topic><topic>Physical Exertion</topic><topic>RADIOISOTOPE SCANNING</topic><topic>Radioisotopes</topic><topic>RADIOLOGY</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radionuclide Imaging</topic><topic>RESPIRATION</topic><topic>SCINTISCANNING</topic><topic>Space life sciences</topic><topic>Stroke Volume</topic><topic>Thallium</topic><topic>THALLIUM ISOTOPES</topic><topic>VASCULAR DISEASES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dan Mckirnan, M.</creatorcontrib><creatorcontrib>Sullivan, Michael</creatorcontrib><creatorcontrib>Jensen, David</creatorcontrib><creatorcontrib>Froelicher, Victor F.</creatorcontrib><creatorcontrib>Univ. of California, San Diego</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>J. Am. Coll. Cardiol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dan Mckirnan, M.</au><au>Sullivan, Michael</au><au>Jensen, David</au><au>Froelicher, Victor F.</au><aucorp>Univ. of California, San Diego</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treadmill performance and cardiac function in selected patients with coronary heart disease</atitle><jtitle>J. Am. Coll. Cardiol.; (United States)</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>1984-02</date><risdate>1984</risdate><volume>3</volume><issue>2</issue><spage>253</spage><epage>261</epage><pages>253-261</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>To investigate the cardiac determinants of treadmill performance in patients able to exercise to volitional fatigue, 88 patients with coronary heart disease free of angina pectoris were tested. The exercise tests included supine bicycle radionuclide ventriculography, thallium scintigraphy and treadmill testing with expired gas analysis. The number of abnormal Q wave locations, ejection fraction, end-diastolic volume, cardiac output, exercise-induced ST segment depression and thallium scar and ischemia scores were the cardiac variables considered. Rest and exercise ejection fractions were highly correlated to thallium scar score (r = −0.72 to −0.75, p < 0.001), but not to maximal oxygen consumption (r = 0.19 to 0.25, p < 0.05). Fifty-five percent of the variability in predicting treadmill time or estimated maximal oxygen consumption was explained by treadmill test-induced change in heart rate (39%), thallium ischemia score (12%) and cardiac output at rest (4%). The change in heart rate induced by the treadmill test explained only 27% of the variability in measured maximal oxygen consumption.
Myocardial damage predicted ejection fraction at rest and the ability to increase heart rate with treadmill exercise appeared as an essential component of exercise capacity. Exercise capacity was only minimally affected by asymptomatic ischemia and was relatively independent of ventricular function.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6693616</pmid><doi>10.1016/S0735-1097(84)80008-X</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | 550602 -- Medicine-- External Radiation in Diagnostics-- (1980-) 551001 -- Physiological Systems-- Tracer Techniques Adult Aged BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOMEDICAL RADIOGRAPHY BODY Cardiac Output Cardiac Volume Cardiology. Vascular system CARDIOVASCULAR DISEASES CARDIOVASCULAR SYSTEM Coronary Disease - diagnosis Coronary Disease - physiopathology Coronary heart disease COUNTING TECHNIQUES DIAGNOSTIC TECHNIQUES DISEASES DYNAMIC FUNCTION STUDIES ELEMENTS EXERCISE Exercise Test HEART Heart - diagnostic imaging Heart Rate Humans ISCHEMIA ISOTOPES Male Medical sciences MEDICINE Middle Aged Myocardial Contraction NONMETALS NUCLEAR MEDICINE ORGANS OXYGEN Oxygen Consumption PATIENTS Physical Exertion RADIOISOTOPE SCANNING Radioisotopes RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging RESPIRATION SCINTISCANNING Space life sciences Stroke Volume Thallium THALLIUM ISOTOPES VASCULAR DISEASES 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics |
| title | Treadmill performance and cardiac function in selected patients with coronary heart disease |
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