Impaired Natural Killer Activity in Patients With Chronic Lymphocytic Leukemia Is Associated With a Deficiency of Azurophilic Cytoplasmic Granules in Putative NK Cells

This study was undertaken to gain further insight into the severely impaired natural killer (NK) activity we and others have previously observed in patients with chronic lymphocytic leukemia (CLL). Normal individuals' NK cells are large granular lymphocytes (LGL) that (A) bind to and lyse NK-se...

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Veröffentlicht in:	Blood 1984-02, Vol.63 (2), p.305-309
Hauptverfasser:	Kay, Neil E., Zarling, Joyce M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibody-Dependent Cell Cytotoxicity B-Lymphocytes Biological and medical sciences Cell Separation Cytoplasmic Granules Hematologic and hematopoietic diseases Humans Killer Cells, Natural - cytology Leukemia, Lymphoid - blood Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Depletion Medical sciences Monocytes Receptors, Fc
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