Effect of penicillin prophylaxis on nasopharyngeal colonization with Streptococcus pneumoniae in children with sickle cell anemia
Polyavalent pneumococcal vaccine and oral penicillin prophylaxis are frequently used in patients with functional or anatomic asplenia to protect them from fulminant Streptococcus pneumoniae sepsis. We studied nasopharyngeal colonization with pneumococci in 34 patients with sickle cell anemia (aged 6...
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| Veröffentlicht in: | The Journal of pediatrics 1984, Vol.104 (1), p.18-22 |
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| container_title | The Journal of pediatrics |
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| creator | Anglin, David L. Siegel, Jane D. Pacini, David L. Smith, Susan J. Adams, Greg Buchanan, George R. |
| description | Polyavalent pneumococcal vaccine and oral penicillin prophylaxis are frequently used in patients with functional or anatomic asplenia to protect them from fulminant
Streptococcus pneumoniae sepsis. We studied nasopharyngeal colonization with pneumococci in 34 patients with sickle cell anemia (aged 6 months to 5 years) receiving penicillin prophylaxis and in 63 age- and race-matched comparison patients. Patients with sickle cell anemia had fewer positive initial pneumococcal nasopharyngeal cultures than did the comparison group (14.5% vs 34.4%,
P=0.03) and significantly lower carriage rates during the respiratory illness season of November to March (8.7% vs 40.5%,
P=0.05). Penicillin prophylaxis did not result in emergence of penicillin-resistant pneumococci or in an increased carriage rate of
Haemophilus influenzae type b. Our data suggest a mechanism of action for penicillin prophylaxis and provide some evidence for the relative safety of this regimen. |
| doi_str_mv | 10.1016/S0022-3476(84)80582-X |
| format | Article |
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Streptococcus pneumoniae sepsis. We studied nasopharyngeal colonization with pneumococci in 34 patients with sickle cell anemia (aged 6 months to 5 years) receiving penicillin prophylaxis and in 63 age- and race-matched comparison patients. Patients with sickle cell anemia had fewer positive initial pneumococcal nasopharyngeal cultures than did the comparison group (14.5% vs 34.4%,
P=0.03) and significantly lower carriage rates during the respiratory illness season of November to March (8.7% vs 40.5%,
P=0.05). Penicillin prophylaxis did not result in emergence of penicillin-resistant pneumococci or in an increased carriage rate of
Haemophilus influenzae type b. Our data suggest a mechanism of action for penicillin prophylaxis and provide some evidence for the relative safety of this regimen.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(84)80582-X</identifier><identifier>PMID: 6690671</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Anemia, Sickle Cell - complications ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Child, Preschool ; Hematologic and hematopoietic diseases ; Humans ; Infant ; Medical sciences ; Other diseases. Hematologic involvement in other diseases ; Patient Compliance ; Penicillin Resistance ; Penicillins - therapeutic use ; Pharmacology. Drug treatments ; Pneumococcal Infections - prevention & control ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Sepsis - prevention & control ; Serotyping ; Specific populations (family, woman, child, elderly...) ; Streptococcus pneumoniae - drug effects ; Streptococcus pneumoniae - isolation & purification ; Tropical medicine</subject><ispartof>The Journal of pediatrics, 1984, Vol.104 (1), p.18-22</ispartof><rights>1984</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-e1c6c8d97836ce064c68220b8fe76c06bb61d9f138b50d652643ec15bc0b6a5d3</citedby><cites>FETCH-LOGICAL-c389t-e1c6c8d97836ce064c68220b8fe76c06bb61d9f138b50d652643ec15bc0b6a5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(84)80582-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9452215$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6690671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anglin, David L.</creatorcontrib><creatorcontrib>Siegel, Jane D.</creatorcontrib><creatorcontrib>Pacini, David L.</creatorcontrib><creatorcontrib>Smith, Susan J.</creatorcontrib><creatorcontrib>Adams, Greg</creatorcontrib><creatorcontrib>Buchanan, George R.</creatorcontrib><title>Effect of penicillin prophylaxis on nasopharyngeal colonization with Streptococcus pneumoniae in children with sickle cell anemia</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Polyavalent pneumococcal vaccine and oral penicillin prophylaxis are frequently used in patients with functional or anatomic asplenia to protect them from fulminant
Streptococcus pneumoniae sepsis. We studied nasopharyngeal colonization with pneumococci in 34 patients with sickle cell anemia (aged 6 months to 5 years) receiving penicillin prophylaxis and in 63 age- and race-matched comparison patients. Patients with sickle cell anemia had fewer positive initial pneumococcal nasopharyngeal cultures than did the comparison group (14.5% vs 34.4%,
P=0.03) and significantly lower carriage rates during the respiratory illness season of November to March (8.7% vs 40.5%,
P=0.05). Penicillin prophylaxis did not result in emergence of penicillin-resistant pneumococci or in an increased carriage rate of
Haemophilus influenzae type b. Our data suggest a mechanism of action for penicillin prophylaxis and provide some evidence for the relative safety of this regimen.</description><subject>Anemia, Sickle Cell - complications</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Medical sciences</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>Patient Compliance</subject><subject>Penicillin Resistance</subject><subject>Penicillins - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Sepsis - prevention & control</subject><subject>Serotyping</subject><subject>Specific populations (family, woman, child, elderly...)</subject><subject>Streptococcus pneumoniae - drug effects</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><subject>Tropical medicine</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EKkvhI1TyASF6CIzzx3FOqKpaQKrEoSD1ZjmTCWtw7GAnQLnxzfF2V3tFPljW-83Mm2fGzgS8ESDk21uAsiyqupWvVX2uoFFlcfeIbQR0bSFVVT1mmyPylD1L6RsAdDXACTuRsgPZig37ezWOhAsPI5_JW7TOWc_nGObtvTO_beLBc29Sfpt477-ScRyDC97-MYvN2i-7bPntEmleAgbENfHZ0zplwhDPvXBr3RDpQCaL3x1xJOe48TRZ85w9GY1L9OJwn7Iv11efLz8UN5_ef7y8uCmwUt1SkECJauhaVUkkkDVKVZbQq5FaiSD7XoqhG0Wl-gYG2ZSyrghF0yP00jRDdcpe7fvm5X6slBY92bTzkW2ENWkFXZlPm8FmD2IMKUUa9RztlLfXAvQuev0Qvd7lqlWtH6LXd7nu7DBg7ScajlWHrLP-8qCbhMaN0Xi06Yh1dVOWosnYuz1GOYyflqJOaMkjDTbmn9JDsP8x8g_6n6O9</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Anglin, David L.</creator><creator>Siegel, Jane D.</creator><creator>Pacini, David L.</creator><creator>Smith, Susan J.</creator><creator>Adams, Greg</creator><creator>Buchanan, George R.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>Effect of penicillin prophylaxis on nasopharyngeal colonization with Streptococcus pneumoniae in children with sickle cell anemia</title><author>Anglin, David L. ; Siegel, Jane D. ; Pacini, David L. ; Smith, Susan J. ; Adams, Greg ; Buchanan, George R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-e1c6c8d97836ce064c68220b8fe76c06bb61d9f138b50d652643ec15bc0b6a5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Anemia, Sickle Cell - complications</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Medical sciences</topic><topic>Other diseases. Hematologic involvement in other diseases</topic><topic>Patient Compliance</topic><topic>Penicillin Resistance</topic><topic>Penicillins - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Pneumococcal Infections - prevention & control</topic><topic>Prevention and actions</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Sepsis - prevention & control</topic><topic>Serotyping</topic><topic>Specific populations (family, woman, child, elderly...)</topic><topic>Streptococcus pneumoniae - drug effects</topic><topic>Streptococcus pneumoniae - isolation & purification</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anglin, David L.</creatorcontrib><creatorcontrib>Siegel, Jane D.</creatorcontrib><creatorcontrib>Pacini, David L.</creatorcontrib><creatorcontrib>Smith, Susan J.</creatorcontrib><creatorcontrib>Adams, Greg</creatorcontrib><creatorcontrib>Buchanan, George R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anglin, David L.</au><au>Siegel, Jane D.</au><au>Pacini, David L.</au><au>Smith, Susan J.</au><au>Adams, Greg</au><au>Buchanan, George R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of penicillin prophylaxis on nasopharyngeal colonization with Streptococcus pneumoniae in children with sickle cell anemia</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1984</date><risdate>1984</risdate><volume>104</volume><issue>1</issue><spage>18</spage><epage>22</epage><pages>18-22</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Polyavalent pneumococcal vaccine and oral penicillin prophylaxis are frequently used in patients with functional or anatomic asplenia to protect them from fulminant
Streptococcus pneumoniae sepsis. We studied nasopharyngeal colonization with pneumococci in 34 patients with sickle cell anemia (aged 6 months to 5 years) receiving penicillin prophylaxis and in 63 age- and race-matched comparison patients. Patients with sickle cell anemia had fewer positive initial pneumococcal nasopharyngeal cultures than did the comparison group (14.5% vs 34.4%,
P=0.03) and significantly lower carriage rates during the respiratory illness season of November to March (8.7% vs 40.5%,
P=0.05). Penicillin prophylaxis did not result in emergence of penicillin-resistant pneumococci or in an increased carriage rate of
Haemophilus influenzae type b. Our data suggest a mechanism of action for penicillin prophylaxis and provide some evidence for the relative safety of this regimen.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>6690671</pmid><doi>10.1016/S0022-3476(84)80582-X</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of pediatrics, 1984, Vol.104 (1), p.18-22 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anemia, Sickle Cell - complications Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Child, Preschool Hematologic and hematopoietic diseases Humans Infant Medical sciences Other diseases. Hematologic involvement in other diseases Patient Compliance Penicillin Resistance Penicillins - therapeutic use Pharmacology. Drug treatments Pneumococcal Infections - prevention & control Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Sepsis - prevention & control Serotyping Specific populations (family, woman, child, elderly...) Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - isolation & purification Tropical medicine |
| title | Effect of penicillin prophylaxis on nasopharyngeal colonization with Streptococcus pneumoniae in children with sickle cell anemia |
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