The evaluation of low dose pre-operative X-ray therapy in the management of operable rectal cancer; results of a randomly controlled trial

824 patients with operable rectal carcinoma were randomly allocated to be treated by surgery alone, 2000 rad in 10 daily fractions and 500 rad as a single fraction. No difference has been demonstrated in the actuarial survival rates to 5 years. The local recurrence‐free and metastasis‐free rates are...

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Veröffentlicht in:	British journal of surgery 1984-01, Vol.71 (1), p.21-25
Hauptverfasser:	Duncan, W., Smith, A. N., Freedman, L. S., Alderson, M. R., Arnott, S. J., Bleehen, N. M., Bond, W. H., Crowther, D., Deeley, T. J., Duthie, H. L., Dykes, P. W., Fielding, L. P., Flatman, G. E., Goligher, J. C., Hawley, P. R., Hughes, L. E., Joslin, C. A. F., Koriech, O. M., Morson, B. C., Oates, G. D., Peckham, M. J., Sandland, M. R., Schofield, P. F., Slack, W., Slaney, G., Smith, J. A. R., Scott, J. Stewart, Whitehouse, J. M. A., Wrigley, P. F. M., York-Mason, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant X-ray therapy Clinical Trials as Topic Combined Modality Therapy complication rates Humans Postoperative Complications - epidemiology pre-operative treatment Preoperative Care Radiotherapy Dosage Random Allocation rectal cancer Rectal Neoplasms - mortality Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery survival rates Time Factors
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Beschreibung
Zusammenfassung:	824 patients with operable rectal carcinoma were randomly allocated to be treated by surgery alone, 2000 rad in 10 daily fractions and 500 rad as a single fraction. No difference has been demonstrated in the actuarial survival rates to 5 years. The local recurrence‐free and metastasis‐free rates are similar in all groups. There is also no evidence that the pre‐operative radiotherapy benefited patients in subgroups by Dukes' stage. The complication rates were also similar in the three treatment groups.
ISSN:	0007-1323 1365-2168
DOI:	10.1002/bjs.1800710107