Cutaneous Mast Cell Maturation Does Not Depend on an Intact Bone Marrow Microenvironment
We sought to determine whether the maturation of murine cutaneous mast cells from stem cells depends on an intact bone marrow microenvironment. Normal bone marrow cells (+/+) were infused into 2 groups of mast cell-deficient mice: WBB6F1-W/Wv mice and 89Sr-pretreated W/Wv mice. 89Sr is a long-lived...
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| Veröffentlicht in: | J. Invest. Dermatol.; (United States) 1984-01, Vol.82 (1), p.25-27 |
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| container_title | J. Invest. Dermatol.; (United States) |
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| creator | Charley, Michael R. Mikhael, Anwar Sontheimer, Richard D. Gilliam, James N. Bennett, Michael |
| description | We sought to determine whether the maturation of murine cutaneous mast cells from stem cells depends on an intact bone marrow microenvironment. Normal bone marrow cells (+/+) were infused into 2 groups of mast cell-deficient mice: WBB6F1-W/Wv mice and 89Sr-pretreated W/Wv mice. 89Sr is a long-lived bone-seeking radioisotope which provides continuous irradiation of the marrow and thereby ablates the marrow microenvironment.
Skin biopsies revealed that the 89Sr-pretreated mice and the controls had repopulated their skin with mast cells equally well. Natural killer cell function was significantly depressed in the 89Sr-treated mice, confirming that the marrow microenvironment had been functionally altered. We conclude that, although the precursors for cutaneous mast cells are marrow derived, they do not need an intact marrow microenvironment for maturation. |
| doi_str_mv | 10.1111/1523-1747.ep12259043 |
| format | Article |
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Skin biopsies revealed that the 89Sr-pretreated mice and the controls had repopulated their skin with mast cells equally well. Natural killer cell function was significantly depressed in the 89Sr-treated mice, confirming that the marrow microenvironment had been functionally altered. We conclude that, although the precursors for cutaneous mast cells are marrow derived, they do not need an intact marrow microenvironment for maturation.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/1523-1747.ep12259043</identifier><identifier>PMID: 6690627</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>ALKALINE EARTH ISOTOPES ; ANIMAL CELLS ; ANIMAL TISSUES ; ANIMALS ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BIOLOGICAL RADIATION EFFECTS ; BIOLOGY ; Biopsy ; BODY ; BONE MARROW ; Bone Marrow - radiation effects ; Bone Marrow Cells ; CELL DIFFERENTIATION ; CONNECTIVE TISSUE CELLS ; CYTOLOGY ; DAYS LIVING RADIOISOTOPES ; Dermatology ; EVEN-ODD NUCLEI ; Female ; Fundamental and applied biological sciences. Psychology ; HEMATOPOIETIC SYSTEM ; INTERMEDIATE MASS NUCLEI ; INTERNAL IRRADIATION ; IRRADIATION ; ISOTOPES ; Killer Cells, Natural - physiology ; MAMMALS ; MAST CELLS ; Mast Cells - cytology ; MICE ; Mice, Mutant Strains ; Microenvironments ; Natural killer cells ; NUCLEI ; ORGANS ; Radiation ; RADIATION EFFECTS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIOISOTOPES ; RODENTS ; SKIN ; Skin - cytology ; SOMATIC CELLS ; STEM CELLS ; Stem Cells - cytology ; STRONTIUM 89 ; STRONTIUM ISOTOPES ; Strontium Radioisotopes ; TISSUES ; VERTEBRATES 560162 -- Radionuclide Effects, Kinetics, & Toxicology-- Animals, Plants, Microorganisms, & Cells ; Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue</subject><ispartof>J. Invest. Dermatol.; (United States), 1984-01, Vol.82 (1), p.25-27</ispartof><rights>1984 The Society for Investigative Dermatology, Inc</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c472t-3839d059f58b3b766a54dffb7d9e078680295b23dedcc2ee2c3e0f4d8e5b37f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,881,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9731430$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6690627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6628610$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Charley, Michael R.</creatorcontrib><creatorcontrib>Mikhael, Anwar</creatorcontrib><creatorcontrib>Sontheimer, Richard D.</creatorcontrib><creatorcontrib>Gilliam, James N.</creatorcontrib><creatorcontrib>Bennett, Michael</creatorcontrib><creatorcontrib>Univ. of Texas Health Science Center, Dallas</creatorcontrib><title>Cutaneous Mast Cell Maturation Does Not Depend on an Intact Bone Marrow Microenvironment</title><title>J. Invest. Dermatol.; (United States)</title><addtitle>J Invest Dermatol</addtitle><description>We sought to determine whether the maturation of murine cutaneous mast cells from stem cells depends on an intact bone marrow microenvironment. Normal bone marrow cells (+/+) were infused into 2 groups of mast cell-deficient mice: WBB6F1-W/Wv mice and 89Sr-pretreated W/Wv mice. 89Sr is a long-lived bone-seeking radioisotope which provides continuous irradiation of the marrow and thereby ablates the marrow microenvironment.
Skin biopsies revealed that the 89Sr-pretreated mice and the controls had repopulated their skin with mast cells equally well. Natural killer cell function was significantly depressed in the 89Sr-treated mice, confirming that the marrow microenvironment had been functionally altered. We conclude that, although the precursors for cutaneous mast cells are marrow derived, they do not need an intact marrow microenvironment for maturation.</description><subject>ALKALINE EARTH ISOTOPES</subject><subject>ANIMAL CELLS</subject><subject>ANIMAL TISSUES</subject><subject>ANIMALS</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BIOLOGY</subject><subject>Biopsy</subject><subject>BODY</subject><subject>BONE MARROW</subject><subject>Bone Marrow - radiation effects</subject><subject>Bone Marrow Cells</subject><subject>CELL DIFFERENTIATION</subject><subject>CONNECTIVE TISSUE CELLS</subject><subject>CYTOLOGY</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>Dermatology</subject><subject>EVEN-ODD NUCLEI</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HEMATOPOIETIC SYSTEM</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>INTERNAL IRRADIATION</subject><subject>IRRADIATION</subject><subject>ISOTOPES</subject><subject>Killer Cells, Natural - physiology</subject><subject>MAMMALS</subject><subject>MAST CELLS</subject><subject>Mast Cells - cytology</subject><subject>MICE</subject><subject>Mice, Mutant Strains</subject><subject>Microenvironments</subject><subject>Natural killer cells</subject><subject>NUCLEI</subject><subject>ORGANS</subject><subject>Radiation</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIOISOTOPES</subject><subject>RODENTS</subject><subject>SKIN</subject><subject>Skin - cytology</subject><subject>SOMATIC CELLS</subject><subject>STEM CELLS</subject><subject>Stem Cells - cytology</subject><subject>STRONTIUM 89</subject><subject>STRONTIUM ISOTOPES</subject><subject>Strontium Radioisotopes</subject><subject>TISSUES</subject><subject>VERTEBRATES 560162 -- Radionuclide Effects, Kinetics, & Toxicology-- Animals, Plants, Microorganisms, & Cells</subject><subject>Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9rFDEQx4Mo9az-BwqLSPFl2_zaJPsi6FXbQqsvCn0L2WQWI3fJNclW-t-bZY_rW81LwsxnZjLfL0JvCT4l9ZyRjrKWSC5PYUco7XrM2TO0OoSfoxXGlLYU09uX6FXOfzAmgnfqCB0J0WNB5QrdrqdiAsQpNzcml2YNm019lSmZ4mNoziPk5nsszTnsILimhkxorkIxtjRfYoAKpxT_Njfepgjh3qcYthDKa_RiNJsMb_b3Mfr17evP9WV7_ePiav35urVc0tIyxXqHu37s1MAGKYTpuBvHQboesFRCYdp3A2UOnLUUgFoGeOROQTcwORJ2jN4vfWMuXmfrC9jfNoYAtmghqBIEV-hkgXYp3k2Qi976bOuqy-pa4Z5KKfl_QcJrQ05UBT8-DVLVYcUUnlG-oFWgnBOMepf81qQHTbCendSzZXq2TD86Wcve7SdMwxbcoWhvXc1_2OdNtmYzJhOszwesl4xwNq_-acGgmnDvIc0aQbDgfJolctE__Y9_lxC4wA</recordid><startdate>198401</startdate><enddate>198401</enddate><creator>Charley, Michael R.</creator><creator>Mikhael, Anwar</creator><creator>Sontheimer, Richard D.</creator><creator>Gilliam, James N.</creator><creator>Bennett, Michael</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198401</creationdate><title>Cutaneous Mast Cell Maturation Does Not Depend on an Intact Bone Marrow Microenvironment</title><author>Charley, Michael R. ; Mikhael, Anwar ; Sontheimer, Richard D. ; Gilliam, James N. ; Bennett, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-3839d059f58b3b766a54dffb7d9e078680295b23dedcc2ee2c3e0f4d8e5b37f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>ALKALINE EARTH ISOTOPES</topic><topic>ANIMAL CELLS</topic><topic>ANIMAL TISSUES</topic><topic>ANIMALS</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BIOLOGY</topic><topic>Biopsy</topic><topic>BODY</topic><topic>BONE MARROW</topic><topic>Bone Marrow - radiation effects</topic><topic>Bone Marrow Cells</topic><topic>CELL DIFFERENTIATION</topic><topic>CONNECTIVE TISSUE CELLS</topic><topic>CYTOLOGY</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>Dermatology</topic><topic>EVEN-ODD NUCLEI</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HEMATOPOIETIC SYSTEM</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>INTERNAL IRRADIATION</topic><topic>IRRADIATION</topic><topic>ISOTOPES</topic><topic>Killer Cells, Natural - physiology</topic><topic>MAMMALS</topic><topic>MAST CELLS</topic><topic>Mast Cells - cytology</topic><topic>MICE</topic><topic>Mice, Mutant Strains</topic><topic>Microenvironments</topic><topic>Natural killer cells</topic><topic>NUCLEI</topic><topic>ORGANS</topic><topic>Radiation</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIOISOTOPES</topic><topic>RODENTS</topic><topic>SKIN</topic><topic>Skin - cytology</topic><topic>SOMATIC CELLS</topic><topic>STEM CELLS</topic><topic>Stem Cells - cytology</topic><topic>STRONTIUM 89</topic><topic>STRONTIUM ISOTOPES</topic><topic>Strontium Radioisotopes</topic><topic>TISSUES</topic><topic>VERTEBRATES 560162 -- Radionuclide Effects, Kinetics, & Toxicology-- Animals, Plants, Microorganisms, & Cells</topic><topic>Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Charley, Michael R.</creatorcontrib><creatorcontrib>Mikhael, Anwar</creatorcontrib><creatorcontrib>Sontheimer, Richard D.</creatorcontrib><creatorcontrib>Gilliam, James N.</creatorcontrib><creatorcontrib>Bennett, Michael</creatorcontrib><creatorcontrib>Univ. of Texas Health Science Center, Dallas</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>J. Invest. Dermatol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Charley, Michael R.</au><au>Mikhael, Anwar</au><au>Sontheimer, Richard D.</au><au>Gilliam, James N.</au><au>Bennett, Michael</au><aucorp>Univ. of Texas Health Science Center, Dallas</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutaneous Mast Cell Maturation Does Not Depend on an Intact Bone Marrow Microenvironment</atitle><jtitle>J. Invest. Dermatol.; (United States)</jtitle><addtitle>J Invest Dermatol</addtitle><date>1984-01</date><risdate>1984</risdate><volume>82</volume><issue>1</issue><spage>25</spage><epage>27</epage><pages>25-27</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>We sought to determine whether the maturation of murine cutaneous mast cells from stem cells depends on an intact bone marrow microenvironment. Normal bone marrow cells (+/+) were infused into 2 groups of mast cell-deficient mice: WBB6F1-W/Wv mice and 89Sr-pretreated W/Wv mice. 89Sr is a long-lived bone-seeking radioisotope which provides continuous irradiation of the marrow and thereby ablates the marrow microenvironment.
Skin biopsies revealed that the 89Sr-pretreated mice and the controls had repopulated their skin with mast cells equally well. Natural killer cell function was significantly depressed in the 89Sr-treated mice, confirming that the marrow microenvironment had been functionally altered. We conclude that, although the precursors for cutaneous mast cells are marrow derived, they do not need an intact marrow microenvironment for maturation.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>6690627</pmid><doi>10.1111/1523-1747.ep12259043</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | J. Invest. Dermatol.; (United States), 1984-01, Vol.82 (1), p.25-27 |
| issn | 0022-202X 1523-1747 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80927774 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | ALKALINE EARTH ISOTOPES ANIMAL CELLS ANIMAL TISSUES ANIMALS BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL RADIATION EFFECTS BIOLOGY Biopsy BODY BONE MARROW Bone Marrow - radiation effects Bone Marrow Cells CELL DIFFERENTIATION CONNECTIVE TISSUE CELLS CYTOLOGY DAYS LIVING RADIOISOTOPES Dermatology EVEN-ODD NUCLEI Female Fundamental and applied biological sciences. Psychology HEMATOPOIETIC SYSTEM INTERMEDIATE MASS NUCLEI INTERNAL IRRADIATION IRRADIATION ISOTOPES Killer Cells, Natural - physiology MAMMALS MAST CELLS Mast Cells - cytology MICE Mice, Mutant Strains Microenvironments Natural killer cells NUCLEI ORGANS Radiation RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RODENTS SKIN Skin - cytology SOMATIC CELLS STEM CELLS Stem Cells - cytology STRONTIUM 89 STRONTIUM ISOTOPES Strontium Radioisotopes TISSUES VERTEBRATES 560162 -- Radionuclide Effects, Kinetics, & Toxicology-- Animals, Plants, Microorganisms, & Cells Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue |
| title | Cutaneous Mast Cell Maturation Does Not Depend on an Intact Bone Marrow Microenvironment |
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