Early results of surgery in patients considered cimetidine failures
Fifty‐two consecutive unselected duodenal ulcer patients (Group 1), who had failed to respond to cimetidine and who subsequently underwent elective vagotomy and drainage, were studied. All patients were symptomatic on cimetidine in full recommended dosage. This group has been compared with another g...
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| Veröffentlicht in: | British journal of surgery 1984-01, Vol.71 (1), p.67-68 |
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| container_title | British journal of surgery |
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| creator | Pickard, W. R. Mackay, C. |
| description | Fifty‐two consecutive unselected duodenal ulcer patients (Group 1), who had failed to respond to cimetidine and who subsequently underwent elective vagotomy and drainage, were studied. All patients were symptomatic on cimetidine in full recommended dosage. This group has been compared with another group of 634 duodenal ulcer patients (Group 2) undergoing elective vagotomy and drainage in the ‘pre‐cimetidine era’. The groups were similar pre‐operatively with regard to age, sex, length of history and maximal acid output. Completeness of vagotomy and amount of acid reduction were similar in the two groups. The incidence of recurrent ulceration was 5 per cent in Group 1 and 5.7 per cent in Group 2. Although, of necessity, follow‐up is shorter in the cimetidine failures (mean 2.3 years), there is nothing to suggest that failure to respond to cimetidine precludes a satisfactory surgical result. |
| doi_str_mv | 10.1002/bjs.1800710122 |
| format | Article |
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R. ; Mackay, C.</creator><creatorcontrib>Pickard, W. R. ; Mackay, C.</creatorcontrib><description>Fifty‐two consecutive unselected duodenal ulcer patients (Group 1), who had failed to respond to cimetidine and who subsequently underwent elective vagotomy and drainage, were studied. All patients were symptomatic on cimetidine in full recommended dosage. This group has been compared with another group of 634 duodenal ulcer patients (Group 2) undergoing elective vagotomy and drainage in the ‘pre‐cimetidine era’. The groups were similar pre‐operatively with regard to age, sex, length of history and maximal acid output. Completeness of vagotomy and amount of acid reduction were similar in the two groups. The incidence of recurrent ulceration was 5 per cent in Group 1 and 5.7 per cent in Group 2. Although, of necessity, follow‐up is shorter in the cimetidine failures (mean 2.3 years), there is nothing to suggest that failure to respond to cimetidine precludes a satisfactory surgical result.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800710122</identifier><identifier>PMID: 6360303</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Adult ; Biological and medical sciences ; Cimetidine - therapeutic use ; Drainage ; Duodenal ulcer ; Duodenal Ulcer - drug therapy ; Duodenal Ulcer - physiopathology ; Duodenal Ulcer - surgery ; Female ; Gastric Acid - metabolism ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroenterostomy ; histamine H2 receptor blockaders ; Humans ; Insulin ; Male ; Medical sciences ; Other diseases. Semiology ; Postoperative Complications ; Preoperative Care ; Pylorus - surgery ; Stomach. 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Anus ; Time Factors ; Vagotomy</subject><ispartof>British journal of surgery, 1984-01, Vol.71 (1), p.67-68</ispartof><rights>Copyright © 1984 British Journal of Surgery Society Ltd.</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3682-1c12c96d7e9b4592c28d1d8753825f3ef9b4c6944c120d72bace996ad1de31593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800710122$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800710122$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9532368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6360303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pickard, W. R.</creatorcontrib><creatorcontrib>Mackay, C.</creatorcontrib><title>Early results of surgery in patients considered cimetidine failures</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Fifty‐two consecutive unselected duodenal ulcer patients (Group 1), who had failed to respond to cimetidine and who subsequently underwent elective vagotomy and drainage, were studied. All patients were symptomatic on cimetidine in full recommended dosage. This group has been compared with another group of 634 duodenal ulcer patients (Group 2) undergoing elective vagotomy and drainage in the ‘pre‐cimetidine era’. The groups were similar pre‐operatively with regard to age, sex, length of history and maximal acid output. Completeness of vagotomy and amount of acid reduction were similar in the two groups. The incidence of recurrent ulceration was 5 per cent in Group 1 and 5.7 per cent in Group 2. Although, of necessity, follow‐up is shorter in the cimetidine failures (mean 2.3 years), there is nothing to suggest that failure to respond to cimetidine precludes a satisfactory surgical result.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cimetidine - therapeutic use</subject><subject>Drainage</subject><subject>Duodenal ulcer</subject><subject>Duodenal Ulcer - drug therapy</subject><subject>Duodenal Ulcer - physiopathology</subject><subject>Duodenal Ulcer - surgery</subject><subject>Female</subject><subject>Gastric Acid - metabolism</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastroenterostomy</subject><subject>histamine H2 receptor blockaders</subject><subject>Humans</subject><subject>Insulin</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Postoperative Complications</subject><subject>Preoperative Care</subject><subject>Pylorus - surgery</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Time Factors</subject><subject>Vagotomy</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPwzAQhC0EKqVw5YaUA-KW4kfjxEcIpYAKHMpLXCzH2SBDHsVOBPn3GLVqT6ud-WalHYSOCR4TjOl59unGJME4JphQuoOGhPEopIQnu2iIvR4SRtk-OnDuE2PCcEQHaMAZxwyzIUqnypZ9YMF1ZeuCpghcZz_A9oGpg6VqDdRe1k3tTA4W8kCbClqTmxqCQpmy88lDtFeo0sHReo7Q8_X0Kb0J54-z2_RiHmrGExoSTagWPI9BZJNIUE2TnORJHLGERgWDwsuai8nEcziPaaY0CMGVh4CRSLAROlvdXdrmuwPXyso4DWWpamg6JxMsKCc49uDJGuyyCnK5tKZStpfrr71_uvaV06osrKq1cRtMRL4xnnhMrLAfU0K_sQmW_81L37zcNi8v7xbbzWfDVda4Fn43WWW_JI9ZHMnXh5mcLa7e3u9f5jJlf3XOhbI</recordid><startdate>198401</startdate><enddate>198401</enddate><creator>Pickard, W. R.</creator><creator>Mackay, C.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198401</creationdate><title>Early results of surgery in patients considered cimetidine failures</title><author>Pickard, W. R. ; Mackay, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3682-1c12c96d7e9b4592c28d1d8753825f3ef9b4c6944c120d72bace996ad1de31593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cimetidine - therapeutic use</topic><topic>Drainage</topic><topic>Duodenal ulcer</topic><topic>Duodenal Ulcer - drug therapy</topic><topic>Duodenal Ulcer - physiopathology</topic><topic>Duodenal Ulcer - surgery</topic><topic>Female</topic><topic>Gastric Acid - metabolism</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastroenterostomy</topic><topic>histamine H2 receptor blockaders</topic><topic>Humans</topic><topic>Insulin</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Postoperative Complications</topic><topic>Preoperative Care</topic><topic>Pylorus - surgery</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Time Factors</topic><topic>Vagotomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pickard, W. R.</creatorcontrib><creatorcontrib>Mackay, C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pickard, W. R.</au><au>Mackay, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early results of surgery in patients considered cimetidine failures</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1984-01</date><risdate>1984</risdate><volume>71</volume><issue>1</issue><spage>67</spage><epage>68</epage><pages>67-68</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Fifty‐two consecutive unselected duodenal ulcer patients (Group 1), who had failed to respond to cimetidine and who subsequently underwent elective vagotomy and drainage, were studied. All patients were symptomatic on cimetidine in full recommended dosage. This group has been compared with another group of 634 duodenal ulcer patients (Group 2) undergoing elective vagotomy and drainage in the ‘pre‐cimetidine era’. The groups were similar pre‐operatively with regard to age, sex, length of history and maximal acid output. Completeness of vagotomy and amount of acid reduction were similar in the two groups. The incidence of recurrent ulceration was 5 per cent in Group 1 and 5.7 per cent in Group 2. Although, of necessity, follow‐up is shorter in the cimetidine failures (mean 2.3 years), there is nothing to suggest that failure to respond to cimetidine precludes a satisfactory surgical result.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>6360303</pmid><doi>10.1002/bjs.1800710122</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1323 |
| ispartof | British journal of surgery, 1984-01, Vol.71 (1), p.67-68 |
| issn | 0007-1323 1365-2168 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Biological and medical sciences Cimetidine - therapeutic use Drainage Duodenal ulcer Duodenal Ulcer - drug therapy Duodenal Ulcer - physiopathology Duodenal Ulcer - surgery Female Gastric Acid - metabolism Gastroenterology. Liver. Pancreas. Abdomen Gastroenterostomy histamine H2 receptor blockaders Humans Insulin Male Medical sciences Other diseases. Semiology Postoperative Complications Preoperative Care Pylorus - surgery Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Time Factors Vagotomy |
| title | Early results of surgery in patients considered cimetidine failures |
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