The roles of nadh in the support of steroid aromatization by human placental microsomes

The ability of NADH to function as an alternative cofactor for the support of estrogen biosynthesis was validated. NADH supported rates of aromatization of up to 80% of those obtained with NADPH, with an apparent K m of 0.70 mM, and stimulated the NADPH-supported reaction only when supplies of the n...

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Veröffentlicht in:	Steroids 1983-07, Vol.42 (1), p.77-91
Hauptverfasser:	Sheean, Leon A., Meigs, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Aromatase - metabolism Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Glucosephosphate Dehydrogenase - metabolism Humans Kinetics Leuconostoc - enzymology Microsomes - metabolism NAD - metabolism NADPH-Ferrihemoprotein Reductase - metabolism Other biological molecules Oxidation-Reduction Oxidoreductases - metabolism Placenta - metabolism Pregnancy Terpenes, steroids. Hormones
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