Study of benzphetamine-N-demethylase in streptozotocin-diabetic mice and rats: evidence for the induction of catalytically and immunologically specific forms of cytochrome P450
Phenobarbital treatment and streptozotocin-diabetes both increase, in mouse and rat microsomes, a benzphetamine-N-demethylase activity which can be inhibited by a specific antibody raised against purified rat phenobarbital-induced cytochrome P-450. However, similar studies performed on cytochrome P-...
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| Veröffentlicht in: | Biochimie 1983-11, Vol.65 (11-12), p.679-683 |
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| container_issue | 11-12 |
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| container_title | Biochimie |
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| creator | ROUER, E LE PROVOST, E LEROUX, J.-P |
| description | Phenobarbital treatment and streptozotocin-diabetes both increase, in mouse and rat microsomes, a benzphetamine-N-demethylase activity which can be inhibited by a specific antibody raised against purified rat phenobarbital-induced cytochrome P-450. However, similar studies performed on cytochrome P-450 A and B fractions separated by DEAE-cellulose chromatography, clearly proved that streptozotocin-diabetes promotes in mice the synthesis of two new species of cytochrome P-450 and that the streptozotocin diabetes-induced forms are different in mouse and rat. No such modifications were observed in the mixed-function oxidase system of congenitally diabetic mice. |
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However, similar studies performed on cytochrome P-450 A and B fractions separated by DEAE-cellulose chromatography, clearly proved that streptozotocin-diabetes promotes in mice the synthesis of two new species of cytochrome P-450 and that the streptozotocin diabetes-induced forms are different in mouse and rat. No such modifications were observed in the mixed-function oxidase system of congenitally diabetic mice.</description><identifier>ISSN: 0300-9084</identifier><identifier>EISSN: 1638-6183</identifier><identifier>PMID: 6201195</identifier><identifier>CODEN: BICMBE</identifier><language>eng</language><publisher>Paris: Elsevier</publisher><subject>Animals ; benzphetamine-N-demethylase ; Biological and medical sciences ; cytochrome P-450 ; Cytochrome P-450 Enzyme System - biosynthesis ; Cytochrome P-450 Enzyme System - immunology ; diabetes mellitus ; Diabetes Mellitus, Experimental - enzymology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enzyme Induction - drug effects ; Epitopes - immunology ; Immunodiffusion ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Microsomes, Liver - enzymology ; Oxidoreductases, N-Demethylating - metabolism ; Phenobarbital - pharmacology ; Rats ; Rats, Inbred Strains</subject><ispartof>Biochimie, 1983-11, Vol.65 (11-12), p.679-683</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8865524$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6201195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROUER, E</creatorcontrib><creatorcontrib>LE PROVOST, E</creatorcontrib><creatorcontrib>LEROUX, J.-P</creatorcontrib><title>Study of benzphetamine-N-demethylase in streptozotocin-diabetic mice and rats: evidence for the induction of catalytically and immunologically specific forms of cytochrome P450</title><title>Biochimie</title><addtitle>Biochimie</addtitle><description>Phenobarbital treatment and streptozotocin-diabetes both increase, in mouse and rat microsomes, a benzphetamine-N-demethylase activity which can be inhibited by a specific antibody raised against purified rat phenobarbital-induced cytochrome P-450. However, similar studies performed on cytochrome P-450 A and B fractions separated by DEAE-cellulose chromatography, clearly proved that streptozotocin-diabetes promotes in mice the synthesis of two new species of cytochrome P-450 and that the streptozotocin diabetes-induced forms are different in mouse and rat. No such modifications were observed in the mixed-function oxidase system of congenitally diabetic mice.</description><subject>Animals</subject><subject>benzphetamine-N-demethylase</subject><subject>Biological and medical sciences</subject><subject>cytochrome P-450</subject><subject>Cytochrome P-450 Enzyme System - biosynthesis</subject><subject>Cytochrome P-450 Enzyme System - immunology</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - enzymology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Enzyme Induction - drug effects</subject><subject>Epitopes - immunology</subject><subject>Immunodiffusion</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Obese</subject><subject>Microsomes, Liver - enzymology</subject><subject>Oxidoreductases, N-Demethylating - metabolism</subject><subject>Phenobarbital - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0300-9084</issn><issn>1638-6183</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1q3TAQhU1JSG_TPkJAi5CdQX9W5OxKaJvAJS0kWV_G0jhXwZIcSy44T9VHrG5qus1qhpnznQMzH6oNU0LXimlxVG2ooLRuqZYfq08pPVNKG8rbk-pEccpY22yqP_d5tguJPekwvI57zOBdwPqutugx75cBEhIXSMoTjjm-xhyNC7V10GF2hnhnkECwZIKcrgj-dhZDGfVxInl_QO1ssovhkGEgw7AUDIZheaOc93OIQ3xaZ2lE4_riW3if3pilJO6n6JH8kg39XB33MCT8stbT6vH7t4frm3r788ft9ddtPbJW5xr6XmuJnWiVBDSXxoBuVScAwRrBdCsNo_RSc9VYwVXpe64E5ZZ1poi4OK0u_vmOU3yZMeWdd8ngMEDAOKedprplQsp3hUxoJSU_OJ6twrnzaHfj5DxMy279Rdmfr3tI5Rj9BMG49F-mtWoaLsVfuGCXPA</recordid><startdate>198311</startdate><enddate>198311</enddate><creator>ROUER, E</creator><creator>LE PROVOST, E</creator><creator>LEROUX, J.-P</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198311</creationdate><title>Study of benzphetamine-N-demethylase in streptozotocin-diabetic mice and rats: evidence for the induction of catalytically and immunologically specific forms of cytochrome P450</title><author>ROUER, E ; LE PROVOST, E ; LEROUX, J.-P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p198t-aff884eb3964aec7cca896b3aeadc31894c10078265d326100f26302d1bc3ae23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>benzphetamine-N-demethylase</topic><topic>Biological and medical sciences</topic><topic>cytochrome P-450</topic><topic>Cytochrome P-450 Enzyme System - biosynthesis</topic><topic>Cytochrome P-450 Enzyme System - immunology</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - enzymology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Enzyme Induction - drug effects</topic><topic>Epitopes - immunology</topic><topic>Immunodiffusion</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Obese</topic><topic>Microsomes, Liver - enzymology</topic><topic>Oxidoreductases, N-Demethylating - metabolism</topic><topic>Phenobarbital - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROUER, E</creatorcontrib><creatorcontrib>LE PROVOST, E</creatorcontrib><creatorcontrib>LEROUX, J.-P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROUER, E</au><au>LE PROVOST, E</au><au>LEROUX, J.-P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of benzphetamine-N-demethylase in streptozotocin-diabetic mice and rats: evidence for the induction of catalytically and immunologically specific forms of cytochrome P450</atitle><jtitle>Biochimie</jtitle><addtitle>Biochimie</addtitle><date>1983-11</date><risdate>1983</risdate><volume>65</volume><issue>11-12</issue><spage>679</spage><epage>683</epage><pages>679-683</pages><issn>0300-9084</issn><eissn>1638-6183</eissn><coden>BICMBE</coden><abstract>Phenobarbital treatment and streptozotocin-diabetes both increase, in mouse and rat microsomes, a benzphetamine-N-demethylase activity which can be inhibited by a specific antibody raised against purified rat phenobarbital-induced cytochrome P-450. However, similar studies performed on cytochrome P-450 A and B fractions separated by DEAE-cellulose chromatography, clearly proved that streptozotocin-diabetes promotes in mice the synthesis of two new species of cytochrome P-450 and that the streptozotocin diabetes-induced forms are different in mouse and rat. No such modifications were observed in the mixed-function oxidase system of congenitally diabetic mice.</abstract><cop>Paris</cop><pub>Elsevier</pub><pmid>6201195</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9084 |
| ispartof | Biochimie, 1983-11, Vol.65 (11-12), p.679-683 |
| issn | 0300-9084 1638-6183 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80891344 |
| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Animals benzphetamine-N-demethylase Biological and medical sciences cytochrome P-450 Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - immunology diabetes mellitus Diabetes Mellitus, Experimental - enzymology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme Induction - drug effects Epitopes - immunology Immunodiffusion Male Medical sciences Mice Mice, Inbred C57BL Mice, Obese Microsomes, Liver - enzymology Oxidoreductases, N-Demethylating - metabolism Phenobarbital - pharmacology Rats Rats, Inbred Strains |
| title | Study of benzphetamine-N-demethylase in streptozotocin-diabetic mice and rats: evidence for the induction of catalytically and immunologically specific forms of cytochrome P450 |
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