Prolactin-releasing activity of porcine intestinal peptide (PHI-27)
Porcine intestinal peptide (PHI), a twenty-seven amino acid peptide isolated from porcine gut extracts, is a close structural homolog of the secretin family hormones. The structural and biological similarities of PHI to vasoactive intestinal peptide (VIP) together with its presence in the rat hypoth...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1983-11, Vol.4 (6), p.817-819 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Samson, W.K. Lumpkin, M.D. McDonald, J.K. McCann, S.M. |
| description | Porcine intestinal peptide (PHI), a twenty-seven amino acid peptide isolated from porcine gut extracts, is a close structural homolog of the secretin family hormones. The structural and biological similarities of PHI to vasoactive intestinal peptide (VIP) together with its presence in the rat hypothalamus suggested a possible role for the peptide in the control of prolactin (PRL) secretion. PHI induced significant, dose-related stimulations of PRL release from cultured, dispersed rat pituitary cells
in vitro. The minimum effective dose is 10
7 molar, compared to 10
9 molar for VIP. No interactive effect with thyrotropin-releasing hormone was observed; however, PHI partially overcame the dopamine inhibition of PRL release. |
| doi_str_mv | 10.1016/0196-9781(83)90073-6 |
| format | Article |
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in vitro. The minimum effective dose is 10
7 molar, compared to 10
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in vitro. The minimum effective dose is 10
7 molar, compared to 10
9 molar for VIP. No interactive effect with thyrotropin-releasing hormone was observed; however, PHI partially overcame the dopamine inhibition of PRL release.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Hormones - pharmacology</subject><subject>Glucagon - pharmacology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Male</subject><subject>Peptide PHI</subject><subject>Peptides - pharmacology</subject><subject>Pituitary Gland, Anterior - drug effects</subject><subject>Pituitary Gland, Anterior - metabolism</subject><subject>Porcine intestinal peptide</subject><subject>Prolactin - metabolism</subject><subject>Prolactin secretion</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Secretin - pharmacology</subject><subject>Thyrotropin - metabolism</subject><subject>Vasoactive Intestinal Peptide - pharmacology</subject><subject>Vertebrates: endocrinology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQQIMotVb_gcIeRNrDarIf2clFkKK2ULAHPYeYnUhku7sm20L_vVm79Ogpk5k3w8wj5JrRe0YZf6BM8FgUwKaQzgSlRRrzEzJmEIKccXFKxkfknFx4_00pzTIBIzLiHEROszGZr11TKd3ZOnZYofK2_or6_852-6gxUds4bWuMbN2hD5iqohbbzpYYTdeLZZwUs0tyZlTl8Wp4J-Tj5fl9vohXb6_L-dMq1inwLs5EWaTMFFopUJTlAKYQBnIV8lgYQXPMEk5NqRPNckwgpXkGjCU8L4twQzohd4e5rWt-tmEbubFeY1WpGputl0ABBGNZALMDqF3jvUMjW2c3yu0lo7J3J3sxshcjIZV_7iQPbTfD_O3nBstj0yAr1G-HuvJaVcapWlt_xASHVAgRsMcDhsHFzqKTXlusNZbWoe5k2dj_9_gFWz-Ilw</recordid><startdate>198311</startdate><enddate>198311</enddate><creator>Samson, W.K.</creator><creator>Lumpkin, M.D.</creator><creator>McDonald, J.K.</creator><creator>McCann, S.M.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198311</creationdate><title>Prolactin-releasing activity of porcine intestinal peptide (PHI-27)</title><author>Samson, W.K. ; Lumpkin, M.D. ; McDonald, J.K. ; McCann, S.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-49d731f7caa8a01588f79f85a9d7e7f905e4260fdc2c15e283054811265d77813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal Hormones - pharmacology</topic><topic>Glucagon - pharmacology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Male</topic><topic>Peptide PHI</topic><topic>Peptides - pharmacology</topic><topic>Pituitary Gland, Anterior - drug effects</topic><topic>Pituitary Gland, Anterior - metabolism</topic><topic>Porcine intestinal peptide</topic><topic>Prolactin - metabolism</topic><topic>Prolactin secretion</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Secretin - pharmacology</topic><topic>Thyrotropin - metabolism</topic><topic>Vasoactive Intestinal Peptide - pharmacology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samson, W.K.</creatorcontrib><creatorcontrib>Lumpkin, M.D.</creatorcontrib><creatorcontrib>McDonald, J.K.</creatorcontrib><creatorcontrib>McCann, S.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samson, W.K.</au><au>Lumpkin, M.D.</au><au>McDonald, J.K.</au><au>McCann, S.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolactin-releasing activity of porcine intestinal peptide (PHI-27)</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1983-11</date><risdate>1983</risdate><volume>4</volume><issue>6</issue><spage>817</spage><epage>819</epage><pages>817-819</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Porcine intestinal peptide (PHI), a twenty-seven amino acid peptide isolated from porcine gut extracts, is a close structural homolog of the secretin family hormones. The structural and biological similarities of PHI to vasoactive intestinal peptide (VIP) together with its presence in the rat hypothalamus suggested a possible role for the peptide in the control of prolactin (PRL) secretion. PHI induced significant, dose-related stimulations of PRL release from cultured, dispersed rat pituitary cells
in vitro. The minimum effective dose is 10
7 molar, compared to 10
9 molar for VIP. No interactive effect with thyrotropin-releasing hormone was observed; however, PHI partially overcame the dopamine inhibition of PRL release.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6689504</pmid><doi>10.1016/0196-9781(83)90073-6</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 1983-11, Vol.4 (6), p.817-819 |
| issn | 0196-9781 1873-5169 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cells, Cultured Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Gastrointestinal Hormones - pharmacology Glucagon - pharmacology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Male Peptide PHI Peptides - pharmacology Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Porcine intestinal peptide Prolactin - metabolism Prolactin secretion Radioimmunoassay Rats Rats, Inbred Strains Secretin - pharmacology Thyrotropin - metabolism Vasoactive Intestinal Peptide - pharmacology Vertebrates: endocrinology |
| title | Prolactin-releasing activity of porcine intestinal peptide (PHI-27) |
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