Secretory IgA, a major immunoglobulin in most bovine external secretions
Bovine secretory IgA (SIgA), recently identified in colostrum, was shown to be homologous to human SIgA by immunologic cross-reaction. A quantitative study indicated that bovine SIgA, a minor component of colostrum, is a major immunoglobulin in most other external secretions including saliva, sperma...
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| Veröffentlicht in: | The Journal of immunology (1950) 1971-02, Vol.106 (2), p.552-563 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 106 |
| creator | Mach, J.P Pahud, J.J |
| description | Bovine secretory IgA (SIgA), recently identified in colostrum, was shown to be homologous to human SIgA by immunologic cross-reaction. A quantitative study indicated that bovine SIgA, a minor component of colostrum, is a major immunoglobulin in most other external secretions including saliva, spermatic fluid, lacrimal, nasal and gastrointestinal secretions. SIgA was isolated from saliva. The free form of secretory component was found to be abundant in milk. A normal lactating cow produces about 1.2 g of this protein per day. Two forms of IgA were identified in serum: a normal serum IgA with no secretory antigenic determinant, and a small amount of SIgA. In vitro synthesis of SIgA by the salivary gland was studied by tissue cultures with incorporation of labeled amino acids. |
| doi_str_mv | 10.4049/jimmunol.106.2.552 |
| format | Article |
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A quantitative study indicated that bovine SIgA, a minor component of colostrum, is a major immunoglobulin in most other external secretions including saliva, spermatic fluid, lacrimal, nasal and gastrointestinal secretions. SIgA was isolated from saliva. The free form of secretory component was found to be abundant in milk. A normal lactating cow produces about 1.2 g of this protein per day. Two forms of IgA were identified in serum: a normal serum IgA with no secretory antigenic determinant, and a small amount of SIgA. 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| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | animal science Animals Antigens - analysis Autoradiography Carbon Isotopes Cattle Chromatography Colostrum - immunology Epitopes zoology |
| title | Secretory IgA, a major immunoglobulin in most bovine external secretions |
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