Comparative intranasal pharmacokinetics of interferon using two spray systems
Physician-administered and self-administered interferon (IFN) nasal sprays were compared by measuring residual IFN recovered from the nose at intervals following single doses. Amounts of IFN recovered five minutes after administration and the decay curves of recoverable antiviral and immunoreactive...
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| Veröffentlicht in: | Journal of interferon research 1983, Vol.3 (4), p.443-449 |
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| container_end_page | 449 |
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| container_issue | 4 |
| container_start_page | 443 |
| container_title | Journal of interferon research |
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| creator | Davies, H W Scott, G M Robinson, J A Higgins, P G Wootton, R Tyrrell, D A |
| description | Physician-administered and self-administered interferon (IFN) nasal sprays were compared by measuring residual IFN recovered from the nose at intervals following single doses. Amounts of IFN recovered five minutes after administration and the decay curves of recoverable antiviral and immunoreactive IFN with time were variable between volunteers but similar for both methods. It follows that a self-administered IFN spray would be suitable for future trials of IFN in upper respiratory infections. It was also confirmed that IFN persists in the nose for at least 24 h and is not all recovered by nasal washing, suggesting that it may be bound to, then slowly released from, nasal mucosal cells. |
| doi_str_mv | 10.1089/jir.1983.3.443 |
| format | Article |
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Amounts of IFN recovered five minutes after administration and the decay curves of recoverable antiviral and immunoreactive IFN with time were variable between volunteers but similar for both methods. It follows that a self-administered IFN spray would be suitable for future trials of IFN in upper respiratory infections. It was also confirmed that IFN persists in the nose for at least 24 h and is not all recovered by nasal washing, suggesting that it may be bound to, then slowly released from, nasal mucosal cells.</description><identifier>ISSN: 0197-8357</identifier><identifier>DOI: 10.1089/jir.1983.3.443</identifier><identifier>PMID: 6672115</identifier><language>eng</language><publisher>United States</publisher><subject>Administration, Intranasal - instrumentation ; Humans ; Interferon Type I - administration & dosage ; Interferon Type I - isolation & purification ; Interferon Type I - metabolism ; Kinetics ; Nasal Mucosa - metabolism ; Self Administration</subject><ispartof>Journal of interferon research, 1983, Vol.3 (4), p.443-449</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c205t-1847e9b47111ff6e55ec2cbf24760d3bea63e3b0830105844ff7a22ba72d2e213</citedby><cites>FETCH-LOGICAL-c205t-1847e9b47111ff6e55ec2cbf24760d3bea63e3b0830105844ff7a22ba72d2e213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3041,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6672115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davies, H W</creatorcontrib><creatorcontrib>Scott, G M</creatorcontrib><creatorcontrib>Robinson, J A</creatorcontrib><creatorcontrib>Higgins, P G</creatorcontrib><creatorcontrib>Wootton, R</creatorcontrib><creatorcontrib>Tyrrell, D A</creatorcontrib><title>Comparative intranasal pharmacokinetics of interferon using two spray systems</title><title>Journal of interferon research</title><addtitle>J Interferon Res</addtitle><description>Physician-administered and self-administered interferon (IFN) nasal sprays were compared by measuring residual IFN recovered from the nose at intervals following single doses. Amounts of IFN recovered five minutes after administration and the decay curves of recoverable antiviral and immunoreactive IFN with time were variable between volunteers but similar for both methods. It follows that a self-administered IFN spray would be suitable for future trials of IFN in upper respiratory infections. It was also confirmed that IFN persists in the nose for at least 24 h and is not all recovered by nasal washing, suggesting that it may be bound to, then slowly released from, nasal mucosal cells.</description><subject>Administration, Intranasal - instrumentation</subject><subject>Humans</subject><subject>Interferon Type I - administration & dosage</subject><subject>Interferon Type I - isolation & purification</subject><subject>Interferon Type I - metabolism</subject><subject>Kinetics</subject><subject>Nasal Mucosa - metabolism</subject><subject>Self Administration</subject><issn>0197-8357</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAUhT2ASimsbEiZ2BL8SGJnRBUvqYgFZstJr8EliYOvA-q_J1ErpjOc75zhI-SK0YxRVd3uXMhYpUQmsjwXJ2RJWSVTJQp5Rs4Rd5SWheRsQRZlOSUrluRl7bvBBBPdDySuj8H0Bk2bDJ8mdKbxX66H6BpMvJ1rCBaC75MRXf-RxF-f4BDMPsE9Rujwgpxa0yJcHnNF3h_u39ZP6eb18Xl9t0kbTouYMpVLqOpcMsasLaEooOFNbXkuS7oVNZhSgKipEpTRQuW5tdJwXhvJtxw4Eytyc_gdgv8eAaPuHDbQtqYHP6JWVCnOJZ3A7AA2wSMGsHoIrjNhrxnVszM9OdOzMy305GwaXB-fx7qD7T9-FCb-AEhUay8</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Davies, H W</creator><creator>Scott, G M</creator><creator>Robinson, J A</creator><creator>Higgins, P G</creator><creator>Wootton, R</creator><creator>Tyrrell, D A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Comparative intranasal pharmacokinetics of interferon using two spray systems</title><author>Davies, H W ; Scott, G M ; Robinson, J A ; Higgins, P G ; Wootton, R ; Tyrrell, D A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c205t-1847e9b47111ff6e55ec2cbf24760d3bea63e3b0830105844ff7a22ba72d2e213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Administration, Intranasal - instrumentation</topic><topic>Humans</topic><topic>Interferon Type I - administration & dosage</topic><topic>Interferon Type I - isolation & purification</topic><topic>Interferon Type I - metabolism</topic><topic>Kinetics</topic><topic>Nasal Mucosa - metabolism</topic><topic>Self Administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davies, H W</creatorcontrib><creatorcontrib>Scott, G M</creatorcontrib><creatorcontrib>Robinson, J A</creatorcontrib><creatorcontrib>Higgins, P G</creatorcontrib><creatorcontrib>Wootton, R</creatorcontrib><creatorcontrib>Tyrrell, D A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of interferon research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davies, H W</au><au>Scott, G M</au><au>Robinson, J A</au><au>Higgins, P G</au><au>Wootton, R</au><au>Tyrrell, D A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative intranasal pharmacokinetics of interferon using two spray systems</atitle><jtitle>Journal of interferon research</jtitle><addtitle>J Interferon Res</addtitle><date>1983</date><risdate>1983</risdate><volume>3</volume><issue>4</issue><spage>443</spage><epage>449</epage><pages>443-449</pages><issn>0197-8357</issn><abstract>Physician-administered and self-administered interferon (IFN) nasal sprays were compared by measuring residual IFN recovered from the nose at intervals following single doses. Amounts of IFN recovered five minutes after administration and the decay curves of recoverable antiviral and immunoreactive IFN with time were variable between volunteers but similar for both methods. It follows that a self-administered IFN spray would be suitable for future trials of IFN in upper respiratory infections. It was also confirmed that IFN persists in the nose for at least 24 h and is not all recovered by nasal washing, suggesting that it may be bound to, then slowly released from, nasal mucosal cells.</abstract><cop>United States</cop><pmid>6672115</pmid><doi>10.1089/jir.1983.3.443</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0197-8357 |
| ispartof | Journal of interferon research, 1983, Vol.3 (4), p.443-449 |
| issn | 0197-8357 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80882270 |
| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Administration, Intranasal - instrumentation Humans Interferon Type I - administration & dosage Interferon Type I - isolation & purification Interferon Type I - metabolism Kinetics Nasal Mucosa - metabolism Self Administration |
| title | Comparative intranasal pharmacokinetics of interferon using two spray systems |
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