Modern concepts of obesity
Recent advances in the classification, etiology, treatment, and theoretical approaches to obesity are reviewed. Human and animal studies are summarized, as they relate to these categories of obesity research. Special attention is given to the possible multiple etiologies of obesity and the roles of...
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Veröffentlicht in: | Nutrition reviews 1983-12, Vol.41 (12), p.361-373 |
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container_title | Nutrition reviews |
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creator | Vasselli, Joseph R Cleary, Margot P Van Itallie, Theodore B |
description | Recent advances in the classification, etiology, treatment, and theoretical approaches to obesity are reviewed. Human and animal studies are summarized, as they relate to these categories of obesity research. Special attention is given to the possible multiple etiologies of obesity and the roles of diet and exercise in weight control. Possible mechanisms underlying inevitable weight regain in reduced obese individuals are discussed relative to cellular and metabolic processes that function in adipose tissue. An hypothesis (termed "the ratchet effect") is offered which suggests than an irreversible increase in adipocytes in some obese subjects may produce increasingly elevated body fat stores that provide a resistance to significant weight reduction. Inferences are drawn for future therapeutic approaches and research directions for obesity attenuation. (wz) |
doi_str_mv | 10.1111/j.1753-4887.1983.tb07142.x |
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Human and animal studies are summarized, as they relate to these categories of obesity research. Special attention is given to the possible multiple etiologies of obesity and the roles of diet and exercise in weight control. Possible mechanisms underlying inevitable weight regain in reduced obese individuals are discussed relative to cellular and metabolic processes that function in adipose tissue. An hypothesis (termed "the ratchet effect") is offered which suggests than an irreversible increase in adipocytes in some obese subjects may produce increasingly elevated body fat stores that provide a resistance to significant weight reduction. Inferences are drawn for future therapeutic approaches and research directions for obesity attenuation. 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Human and animal studies are summarized, as they relate to these categories of obesity research. Special attention is given to the possible multiple etiologies of obesity and the roles of diet and exercise in weight control. Possible mechanisms underlying inevitable weight regain in reduced obese individuals are discussed relative to cellular and metabolic processes that function in adipose tissue. An hypothesis (termed "the ratchet effect") is offered which suggests than an irreversible increase in adipocytes in some obese subjects may produce increasingly elevated body fat stores that provide a resistance to significant weight reduction. Inferences are drawn for future therapeutic approaches and research directions for obesity attenuation. (wz)</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6322060</pmid><doi>10.1111/j.1753-4887.1983.tb07142.x</doi><tpages>13</tpages></addata></record> |
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subjects | adipose tissue Adipose Tissue - metabolism Adipose Tissue - pathology Adult animal experimentation Animals Child Diet, Reducing - standards Dietary Fats - pharmacology Dietary Fiber - administration & dosage Dietary Proteins - administration & dosage Energy Intake Female Humans Hyperphagia - complications Infant, Newborn lipid metabolism Lipoprotein Lipase - physiology literature reviews Male nutrition research obesity Obesity - classification Obesity - etiology Obesity - genetics Obesity - metabolism Obesity - therapy Pregnancy weight loss |
title | Modern concepts of obesity |
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