Effect of Infusions of Osmotically Active Substances on Muscle Blood Flow and Systemic Blood Pressure
To investigate further the action of alterations in plasma osmolarity, the flow through the gastrocnemius-plantaris muscle group and the whole hind leg was measured during close intra-arterial infusions of solutions containing osmotically active substances. The transient and steady-state responses s...
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Veröffentlicht in: | Circulation research 1971-01, Vol.28 (1 Suppl 1), p.33-38 |
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container_title | Circulation research |
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creator | STAINSBY, WENDELL N BARCLAY, JACK K |
description | To investigate further the action of alterations in plasma osmolarity, the flow through the gastrocnemius-plantaris muscle group and the whole hind leg was measured during close intra-arterial infusions of solutions containing osmotically active substances. The transient and steady-state responses showed dilatation during infusion of hypermolal solutions. Some of the transient responses were difficult to explain. Intravenous infusions of hyperosmolal solutions caused an increase in cardiac output, arterial blood pressure, and right atrial pressure and a decrease in resistance to flow through the hind leg. These responses were probably due to constriction of the venous capacitance vessels and dilatation of the precapillary resistance vessels and were caused by some unknown mechanism. |
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The transient and steady-state responses showed dilatation during infusion of hypermolal solutions. Some of the transient responses were difficult to explain. Intravenous infusions of hyperosmolal solutions caused an increase in cardiac output, arterial blood pressure, and right atrial pressure and a decrease in resistance to flow through the hind leg. These responses were probably due to constriction of the venous capacitance vessels and dilatation of the precapillary resistance vessels and were caused by some unknown mechanism.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>PMID: 5541119</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Animals ; Arteries ; Blood Flow Velocity ; Blood Pressure - drug effects ; Cardiac Output - drug effects ; Dilatation - drug effects</subject><ispartof>Circulation research, 1971-01, Vol.28 (1 Suppl 1), p.33-38</ispartof><rights>1971 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5541119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STAINSBY, WENDELL N</creatorcontrib><creatorcontrib>BARCLAY, JACK K</creatorcontrib><title>Effect of Infusions of Osmotically Active Substances on Muscle Blood Flow and Systemic Blood Pressure</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>To investigate further the action of alterations in plasma osmolarity, the flow through the gastrocnemius-plantaris muscle group and the whole hind leg was measured during close intra-arterial infusions of solutions containing osmotically active substances. The transient and steady-state responses showed dilatation during infusion of hypermolal solutions. Some of the transient responses were difficult to explain. Intravenous infusions of hyperosmolal solutions caused an increase in cardiac output, arterial blood pressure, and right atrial pressure and a decrease in resistance to flow through the hind leg. These responses were probably due to constriction of the venous capacitance vessels and dilatation of the precapillary resistance vessels and were caused by some unknown mechanism.</description><subject>Animals</subject><subject>Arteries</subject><subject>Blood Flow Velocity</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiac Output - drug effects</subject><subject>Dilatation - drug effects</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkFFLwzAUhYMoc05_gpAn3wo3TbK0j3NsOphMmD6XNL1l1bSZTeLYv7fDPl3OOR_34bsiUyZTkQip2DWZAkCeKM7hltx5_wXABE_zCZlIKRhj-ZTgqq7RBOpquunq6BvX-UvY-daFxmhrz3RhQvOLdB9LH3RncAA6-ha9sUifrXMVXVt3orqr6P7sA7aNGfv3Hr2PPd6Tm1pbjw_jnZHP9epj-Zpsdy-b5WKbHFPJVJIL4CWf1yarUHCpQavMcJMZlCYTmQFApnhlDCgm8zLVTCmhS1EpmEPKgM_I0__fY-9-IvpQtI03aK3u0EVfZJCpAUwH8HEEY9liVRz7ptX9uRi9DLv430_OBuz9t40n7IsDahsOxaAVOLA0YbliwAatyaVS_A_BDG7V</recordid><startdate>197101</startdate><enddate>197101</enddate><creator>STAINSBY, WENDELL N</creator><creator>BARCLAY, JACK K</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197101</creationdate><title>Effect of Infusions of Osmotically Active Substances on Muscle Blood Flow and Systemic Blood Pressure</title><author>STAINSBY, WENDELL N ; BARCLAY, JACK K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2517-9403b36fc8de435a0a78c3c8ce5c848c00e173dcc07159b2a1774ab4d70602103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Animals</topic><topic>Arteries</topic><topic>Blood Flow Velocity</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiac Output - drug effects</topic><topic>Dilatation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STAINSBY, WENDELL N</creatorcontrib><creatorcontrib>BARCLAY, JACK K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STAINSBY, WENDELL N</au><au>BARCLAY, JACK K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Infusions of Osmotically Active Substances on Muscle Blood Flow and Systemic Blood Pressure</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1971-01</date><risdate>1971</risdate><volume>28</volume><issue>1 Suppl 1</issue><spage>33</spage><epage>38</epage><pages>33-38</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>To investigate further the action of alterations in plasma osmolarity, the flow through the gastrocnemius-plantaris muscle group and the whole hind leg was measured during close intra-arterial infusions of solutions containing osmotically active substances. The transient and steady-state responses showed dilatation during infusion of hypermolal solutions. Some of the transient responses were difficult to explain. Intravenous infusions of hyperosmolal solutions caused an increase in cardiac output, arterial blood pressure, and right atrial pressure and a decrease in resistance to flow through the hind leg. These responses were probably due to constriction of the venous capacitance vessels and dilatation of the precapillary resistance vessels and were caused by some unknown mechanism.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>5541119</pmid><tpages>6</tpages></addata></record> |
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source | MEDLINE; American Heart Association; Journals@Ovid Complete; Free E-Journal (出版社公開部分のみ) |
subjects | Animals Arteries Blood Flow Velocity Blood Pressure - drug effects Cardiac Output - drug effects Dilatation - drug effects |
title | Effect of Infusions of Osmotically Active Substances on Muscle Blood Flow and Systemic Blood Pressure |
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