Cyclic Adenosine Monophosphate and Norepinephrine: Effects on Transmembrane Properties of Cerebellar Purkinje Cells
Electrical properties of Purkinje cells were recorded by intracellular microelectrode during extracellular electrophoretic application of gamma aminobutyrate, norepinephrine, cyclic adenosine monophosphate, and dibutyryl cyclic adenosine monophosphate. All these substances hyperpolarized Purkinje ce...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1971-01, Vol.171 (3967), p.192-194 |
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| container_end_page | 194 |
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| container_issue | 3967 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 171 |
| creator | Siggins, G. R. Oliver, A. P. Hoffer, B. J. Bloom, F. E. |
| description | Electrical properties of Purkinje cells were recorded by intracellular microelectrode during extracellular electrophoretic application of gamma aminobutyrate, norepinephrine, cyclic adenosine monophosphate, and dibutyryl cyclic adenosine monophosphate. All these substances hyperpolarized Purkinje cells. Transmembrane resistance decreased during gamma aminobutyrate hyperpolarization. In contrast, norepinephrine and the cyclic nucleotides generally elevated resistance. These results show that cyclic nucleotides mimic the unique effects of norepinephrine on the bioelectric properties of neuronal membranes. |
| doi_str_mv | 10.1126/science.171.3967.192 |
| format | Article |
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These results show that cyclic nucleotides mimic the unique effects of norepinephrine on the bioelectric properties of neuronal membranes.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.171.3967.192</identifier><identifier>PMID: 4322158</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Adenine Nucleotides - pharmacology ; Aminobutyrates - pharmacology ; Animals ; Cerebellar Cortex - drug effects ; Cerebellar Cortex - physiology ; Cerebellum ; Cyclic AMP - pharmacology ; Cyclic nucleotides ; Lymphocytic choriomeningitis virus ; Membrane potential ; Membrane Potentials - drug effects ; Norepinephrine ; Norepinephrine - pharmacology ; P branes ; Purkinje cells ; Purkinje Cells - drug effects ; Purkinje Cells - physiology ; Rats ; Stimulation, Chemical ; String theory ; Synaptic Transmission ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 1971-01, Vol.171 (3967), p.192-194</ispartof><rights>Copyright 1971 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-8203602e743a059a1948ec5540713c8ee6716ab7be06c0b837c874f34bacafb33</citedby><cites>FETCH-LOGICAL-c334t-8203602e743a059a1948ec5540713c8ee6716ab7be06c0b837c874f34bacafb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1731420$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1731420$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4322158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siggins, G. R.</creatorcontrib><creatorcontrib>Oliver, A. P.</creatorcontrib><creatorcontrib>Hoffer, B. J.</creatorcontrib><creatorcontrib>Bloom, F. E.</creatorcontrib><title>Cyclic Adenosine Monophosphate and Norepinephrine: Effects on Transmembrane Properties of Cerebellar Purkinje Cells</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Electrical properties of Purkinje cells were recorded by intracellular microelectrode during extracellular electrophoretic application of gamma aminobutyrate, norepinephrine, cyclic adenosine monophosphate, and dibutyryl cyclic adenosine monophosphate. All these substances hyperpolarized Purkinje cells. Transmembrane resistance decreased during gamma aminobutyrate hyperpolarization. In contrast, norepinephrine and the cyclic nucleotides generally elevated resistance. These results show that cyclic nucleotides mimic the unique effects of norepinephrine on the bioelectric properties of neuronal membranes.</description><subject>Adenine Nucleotides - pharmacology</subject><subject>Aminobutyrates - pharmacology</subject><subject>Animals</subject><subject>Cerebellar Cortex - drug effects</subject><subject>Cerebellar Cortex - physiology</subject><subject>Cerebellum</subject><subject>Cyclic AMP - pharmacology</subject><subject>Cyclic nucleotides</subject><subject>Lymphocytic choriomeningitis virus</subject><subject>Membrane potential</subject><subject>Membrane Potentials - drug effects</subject><subject>Norepinephrine</subject><subject>Norepinephrine - pharmacology</subject><subject>P branes</subject><subject>Purkinje cells</subject><subject>Purkinje Cells - drug effects</subject><subject>Purkinje Cells - physiology</subject><subject>Rats</subject><subject>Stimulation, Chemical</subject><subject>String theory</subject><subject>Synaptic Transmission</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtuwyAQRVHVqk0ff5BKrLpzCgYD7i6K0ofURxbtGmEyVpza4IK9yN-XKFG7YSTOzNXMQWhKyYzSXNxH24CzMKOSzlgp5IyW-QmaUFIWWZkTdoomhDCRKSKLC3QZ45aQxEp2js45y3NaqAmKi51tG4vna3A-Ng7wm3e-3_jYb8wA2Lg1fvcB-oT6TUjvA17WNdghYu_wZzAudtBVqQJeBd9DGBpIrMYLCFBB25qAV2P4btwW0l_bxmt0Vps2ws2xXqGvx-Xn4jl7_Xh6WcxfM8sYHzKVbhAkB8mZIUVpaMkV2KLgRFJmFYCQVJhKVkCEJZVi0irJa8YrY01dMXaF7g65ffA_I8RBd020-40c-DFqRZQQisrUyA-NNvgYA9S6D01nwk5Toveu9dG1Tq713rVOrtPY7TF_rDpY_w0d5SY-PfBtHHz4z5SM8nTbL6CAh0I</recordid><startdate>19710115</startdate><enddate>19710115</enddate><creator>Siggins, G. 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R.</creatorcontrib><creatorcontrib>Oliver, A. P.</creatorcontrib><creatorcontrib>Hoffer, B. J.</creatorcontrib><creatorcontrib>Bloom, F. E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siggins, G. R.</au><au>Oliver, A. P.</au><au>Hoffer, B. J.</au><au>Bloom, F. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclic Adenosine Monophosphate and Norepinephrine: Effects on Transmembrane Properties of Cerebellar Purkinje Cells</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1971-01-15</date><risdate>1971</risdate><volume>171</volume><issue>3967</issue><spage>192</spage><epage>194</epage><pages>192-194</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Electrical properties of Purkinje cells were recorded by intracellular microelectrode during extracellular electrophoretic application of gamma aminobutyrate, norepinephrine, cyclic adenosine monophosphate, and dibutyryl cyclic adenosine monophosphate. All these substances hyperpolarized Purkinje cells. Transmembrane resistance decreased during gamma aminobutyrate hyperpolarization. In contrast, norepinephrine and the cyclic nucleotides generally elevated resistance. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1971-01, Vol.171 (3967), p.192-194 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80866817 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Adenine Nucleotides - pharmacology Aminobutyrates - pharmacology Animals Cerebellar Cortex - drug effects Cerebellar Cortex - physiology Cerebellum Cyclic AMP - pharmacology Cyclic nucleotides Lymphocytic choriomeningitis virus Membrane potential Membrane Potentials - drug effects Norepinephrine Norepinephrine - pharmacology P branes Purkinje cells Purkinje Cells - drug effects Purkinje Cells - physiology Rats Stimulation, Chemical String theory Synaptic Transmission Viruses |
| title | Cyclic Adenosine Monophosphate and Norepinephrine: Effects on Transmembrane Properties of Cerebellar Purkinje Cells |
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