Nigral dopaminergic mechanisms in drug-induced circling
Unilateral injections of dopamine into the substantia nigra pars reticulata of pargyline-pretreated rats caused a prolonged, contralateral circling, similar in magnitude to that elicited by the injection of the same amount of dopamine intrastriatally. Contralateral circling was also elicited by the...
Gespeichert in:
| Veröffentlicht in: | Brain research bulletin 1983-01, Vol.11 (5), p.605-611 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 611 |
|---|---|
| container_issue | 5 |
| container_start_page | 605 |
| container_title | Brain research bulletin |
| container_volume | 11 |
| creator | Jackson, E.Amanda Kelly, Peter H. |
| description | Unilateral injections of dopamine into the substantia nigra pars reticulata of pargyline-pretreated rats caused a prolonged, contralateral circling, similar in magnitude to that elicited by the injection of the same amount of dopamine intrastriatally. Contralateral circling was also elicited by the unilateral intranigral injection of amphetamine (after pargyline pretreatment), or by the dopamine agonists ergometrine and SKF 38393. In contrast, bilateral intranigral injection of the dopamine antagonist haloperidol greatly reduced the amphetamine-induced circling of rats with unilateral 6-hydroxydopamine-induced nigrostriatal lesions. These results support the hypothesis that dopaminergic mechanisms in the substantia nigra are involved in motor behavior. |
| doi_str_mv | 10.1016/0361-9230(83)90131-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80865849</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0361923083901314</els_id><sourcerecordid>80865849</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-9ca09e4a9e865060625ba3752f8a27f4430b8590c969b31e8aebe15dc30bd17b3</originalsourceid><addsrcrecordid>eNqFkMtKAzEUhoMotV7eQGEWIroYTSaZXDaCFG9QdKPrkEnOjJG51KQj-PamtnSpqwPnfP_P4UPohOArggm_xpSTXBUUX0h6qTChJGc7aEqkoHkhmNhF0y2yjw5i_MAYc1nyCZpwjoXgcorEs2-CaTM3LEznewiNt1kH9t30PnYx833mwtjkvnejBZdZH2zr--YI7dWmjXC8mYfo7f7udfaYz18enma389wyIpa5sgYrYEaB5CXmmBdlZagoi1qaQtSMUVzJUmGruKooAWmgAlI6m_aOiIoeovN17yIMnyPEpe58tNC2podhjFriVCyZ-hckVHDBZJFAtgZtGGIMUOtF8J0J35pgvRKrV9b0ypqWVP-K1SzFTjf9Y9WB24Y2JtP9bHM30Zq2Dqa3Pm4xVXJFC5GwmzUGSdqXh6Cj9dAntT6AXWo3-L__-AE_TpKn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>13767482</pqid></control><display><type>article</type><title>Nigral dopaminergic mechanisms in drug-induced circling</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Jackson, E.Amanda ; Kelly, Peter H.</creator><creatorcontrib>Jackson, E.Amanda ; Kelly, Peter H.</creatorcontrib><description>Unilateral injections of dopamine into the substantia nigra pars reticulata of pargyline-pretreated rats caused a prolonged, contralateral circling, similar in magnitude to that elicited by the injection of the same amount of dopamine intrastriatally. Contralateral circling was also elicited by the unilateral intranigral injection of amphetamine (after pargyline pretreatment), or by the dopamine agonists ergometrine and SKF 38393. In contrast, bilateral intranigral injection of the dopamine antagonist haloperidol greatly reduced the amphetamine-induced circling of rats with unilateral 6-hydroxydopamine-induced nigrostriatal lesions. These results support the hypothesis that dopaminergic mechanisms in the substantia nigra are involved in motor behavior.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/0361-9230(83)90131-4</identifier><identifier>PMID: 6607768</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine ; Animals ; Behavior, Animal - drug effects ; Benzazepines - administration & dosage ; Biological and medical sciences ; Biomechanical Phenomena ; Catecholaminergic system ; Caudate Nucleus ; Corpus Striatum - physiology ; Dextroamphetamine - administration & dosage ; Dopamine - administration & dosage ; Dopamine - metabolism ; Dopamine - physiology ; Dopamine Amphetamine Motor behavior Substantia nigra Circling ; Ergonovine - administration & dosage ; Haloperidol - administration & dosage ; Injections ; Male ; Medical sciences ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Substantia Nigra - physiology</subject><ispartof>Brain research bulletin, 1983-01, Vol.11 (5), p.605-611</ispartof><rights>1983</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-9ca09e4a9e865060625ba3752f8a27f4430b8590c969b31e8aebe15dc30bd17b3</citedby><cites>FETCH-LOGICAL-c417t-9ca09e4a9e865060625ba3752f8a27f4430b8590c969b31e8aebe15dc30bd17b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0361-9230(83)90131-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9569327$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6607768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jackson, E.Amanda</creatorcontrib><creatorcontrib>Kelly, Peter H.</creatorcontrib><title>Nigral dopaminergic mechanisms in drug-induced circling</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>Unilateral injections of dopamine into the substantia nigra pars reticulata of pargyline-pretreated rats caused a prolonged, contralateral circling, similar in magnitude to that elicited by the injection of the same amount of dopamine intrastriatally. Contralateral circling was also elicited by the unilateral intranigral injection of amphetamine (after pargyline pretreatment), or by the dopamine agonists ergometrine and SKF 38393. In contrast, bilateral intranigral injection of the dopamine antagonist haloperidol greatly reduced the amphetamine-induced circling of rats with unilateral 6-hydroxydopamine-induced nigrostriatal lesions. These results support the hypothesis that dopaminergic mechanisms in the substantia nigra are involved in motor behavior.</description><subject>2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Benzazepines - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Catecholaminergic system</subject><subject>Caudate Nucleus</subject><subject>Corpus Striatum - physiology</subject><subject>Dextroamphetamine - administration & dosage</subject><subject>Dopamine - administration & dosage</subject><subject>Dopamine - metabolism</subject><subject>Dopamine - physiology</subject><subject>Dopamine Amphetamine Motor behavior Substantia nigra Circling</subject><subject>Ergonovine - administration & dosage</subject><subject>Haloperidol - administration & dosage</subject><subject>Injections</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Substantia Nigra - physiology</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotV7eQGEWIroYTSaZXDaCFG9QdKPrkEnOjJG51KQj-PamtnSpqwPnfP_P4UPohOArggm_xpSTXBUUX0h6qTChJGc7aEqkoHkhmNhF0y2yjw5i_MAYc1nyCZpwjoXgcorEs2-CaTM3LEznewiNt1kH9t30PnYx833mwtjkvnejBZdZH2zr--YI7dWmjXC8mYfo7f7udfaYz18enma389wyIpa5sgYrYEaB5CXmmBdlZagoi1qaQtSMUVzJUmGruKooAWmgAlI6m_aOiIoeovN17yIMnyPEpe58tNC2podhjFriVCyZ-hckVHDBZJFAtgZtGGIMUOtF8J0J35pgvRKrV9b0ypqWVP-K1SzFTjf9Y9WB24Y2JtP9bHM30Zq2Dqa3Pm4xVXJFC5GwmzUGSdqXh6Cj9dAntT6AXWo3-L__-AE_TpKn</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Jackson, E.Amanda</creator><creator>Kelly, Peter H.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19830101</creationdate><title>Nigral dopaminergic mechanisms in drug-induced circling</title><author>Jackson, E.Amanda ; Kelly, Peter H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-9ca09e4a9e865060625ba3752f8a27f4430b8590c969b31e8aebe15dc30bd17b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Benzazepines - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Catecholaminergic system</topic><topic>Caudate Nucleus</topic><topic>Corpus Striatum - physiology</topic><topic>Dextroamphetamine - administration & dosage</topic><topic>Dopamine - administration & dosage</topic><topic>Dopamine - metabolism</topic><topic>Dopamine - physiology</topic><topic>Dopamine Amphetamine Motor behavior Substantia nigra Circling</topic><topic>Ergonovine - administration & dosage</topic><topic>Haloperidol - administration & dosage</topic><topic>Injections</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Substantia Nigra - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, E.Amanda</creatorcontrib><creatorcontrib>Kelly, Peter H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, E.Amanda</au><au>Kelly, Peter H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nigral dopaminergic mechanisms in drug-induced circling</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>11</volume><issue>5</issue><spage>605</spage><epage>611</epage><pages>605-611</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>Unilateral injections of dopamine into the substantia nigra pars reticulata of pargyline-pretreated rats caused a prolonged, contralateral circling, similar in magnitude to that elicited by the injection of the same amount of dopamine intrastriatally. Contralateral circling was also elicited by the unilateral intranigral injection of amphetamine (after pargyline pretreatment), or by the dopamine agonists ergometrine and SKF 38393. In contrast, bilateral intranigral injection of the dopamine antagonist haloperidol greatly reduced the amphetamine-induced circling of rats with unilateral 6-hydroxydopamine-induced nigrostriatal lesions. These results support the hypothesis that dopaminergic mechanisms in the substantia nigra are involved in motor behavior.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6607768</pmid><doi>10.1016/0361-9230(83)90131-4</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0361-9230 |
| ispartof | Brain research bulletin, 1983-01, Vol.11 (5), p.605-611 |
| issn | 0361-9230 1873-2747 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80865849 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine Animals Behavior, Animal - drug effects Benzazepines - administration & dosage Biological and medical sciences Biomechanical Phenomena Catecholaminergic system Caudate Nucleus Corpus Striatum - physiology Dextroamphetamine - administration & dosage Dopamine - administration & dosage Dopamine - metabolism Dopamine - physiology Dopamine Amphetamine Motor behavior Substantia nigra Circling Ergonovine - administration & dosage Haloperidol - administration & dosage Injections Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Rats Rats, Inbred Strains Substantia Nigra - physiology |
| title | Nigral dopaminergic mechanisms in drug-induced circling |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T13%3A01%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nigral%20dopaminergic%20mechanisms%20in%20drug-induced%20circling&rft.jtitle=Brain%20research%20bulletin&rft.au=Jackson,%20E.Amanda&rft.date=1983-01-01&rft.volume=11&rft.issue=5&rft.spage=605&rft.epage=611&rft.pages=605-611&rft.issn=0361-9230&rft.eissn=1873-2747&rft.coden=BRBUDU&rft_id=info:doi/10.1016/0361-9230(83)90131-4&rft_dat=%3Cproquest_cross%3E80865849%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=13767482&rft_id=info:pmid/6607768&rft_els_id=0361923083901314&rfr_iscdi=true |