Iron metabolism in copper-deficient rats
1. The effects of ingestion of diets deficient in both copper and iron on storage of these elements and on the red cell indices have been studied in rats. 2. Injection of Cu into rats whose stores of Cu had been virtually exhausted resulted in a temporary increase in the concentration of plasma Fe a...
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| Veröffentlicht in: | British journal of nutrition 1971, Vol.25 (1), p.15-30 |
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| container_title | British journal of nutrition |
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| creator | Marston, H. R. Allen, Shirley H. Swaby, S. L. |
| description | 1. The effects of ingestion of diets deficient in both copper and iron on storage of these elements and on the red cell indices have been studied in rats. 2. Injection of Cu into rats whose stores of Cu had been virtually exhausted resulted in a temporary increase in the concentration of plasma Fe and depletion of the Fe stored in the liver. Storage of Fe in the spleen seemed to be affected somewhat differently from that in the liver. 3. Fe injected into Cu-deficient rats was transported to storage sites but, although the plasma Fe concentration was presumably transiently increased thereby, there was no lasting effect. 4. The hypotheses that Cu mediates in the release of Fe from ferritin and that of Osaki, Johnson & Frieden (1966) that caeruloplasmin promotes the rate of Fe-saturation of apotransferrin are discussed. |
| doi_str_mv | 10.1079/BJN19710062 |
| format | Article |
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R. ; Allen, Shirley H. ; Swaby, S. L.</creator><creatorcontrib>Marston, H. R. ; Allen, Shirley H. ; Swaby, S. L.</creatorcontrib><description>1. The effects of ingestion of diets deficient in both copper and iron on storage of these elements and on the red cell indices have been studied in rats. 2. Injection of Cu into rats whose stores of Cu had been virtually exhausted resulted in a temporary increase in the concentration of plasma Fe and depletion of the Fe stored in the liver. Storage of Fe in the spleen seemed to be affected somewhat differently from that in the liver. 3. Fe injected into Cu-deficient rats was transported to storage sites but, although the plasma Fe concentration was presumably transiently increased thereby, there was no lasting effect. 4. The hypotheses that Cu mediates in the release of Fe from ferritin and that of Osaki, Johnson & Frieden (1966) that caeruloplasmin promotes the rate of Fe-saturation of apotransferrin are discussed.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN19710062</identifier><identifier>PMID: 5539290</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Animals ; Body Weight ; Bone Marrow - analysis ; Copper - blood ; Copper - metabolism ; Copper - therapeutic use ; Deficiency Diseases - drug therapy ; Deficiency Diseases - metabolism ; Erythrocyte Count ; Erythrocytes - metabolism ; Ferritins - metabolism ; Hematocrit ; Hemoglobinometry ; Iron - blood ; Iron - metabolism ; Iron - therapeutic use ; Kidney - analysis ; Liver - analysis ; Male ; Myocardium - analysis ; Rats ; Spleen - analysis</subject><ispartof>British journal of nutrition, 1971, Vol.25 (1), p.15-30</ispartof><rights>Copyright © The Nutrition Society 1971</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3122-173f422265c51f2c59691969b703ceb0ee25ba7a9b918bc1ccfadb62929f97b33</citedby><cites>FETCH-LOGICAL-c3122-173f422265c51f2c59691969b703ceb0ee25ba7a9b918bc1ccfadb62929f97b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5539290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marston, H. R.</creatorcontrib><creatorcontrib>Allen, Shirley H.</creatorcontrib><creatorcontrib>Swaby, S. L.</creatorcontrib><title>Iron metabolism in copper-deficient rats</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>1. The effects of ingestion of diets deficient in both copper and iron on storage of these elements and on the red cell indices have been studied in rats. 2. Injection of Cu into rats whose stores of Cu had been virtually exhausted resulted in a temporary increase in the concentration of plasma Fe and depletion of the Fe stored in the liver. Storage of Fe in the spleen seemed to be affected somewhat differently from that in the liver. 3. Fe injected into Cu-deficient rats was transported to storage sites but, although the plasma Fe concentration was presumably transiently increased thereby, there was no lasting effect. 4. The hypotheses that Cu mediates in the release of Fe from ferritin and that of Osaki, Johnson & Frieden (1966) that caeruloplasmin promotes the rate of Fe-saturation of apotransferrin are discussed.</description><subject>Animals</subject><subject>Body Weight</subject><subject>Bone Marrow - analysis</subject><subject>Copper - blood</subject><subject>Copper - metabolism</subject><subject>Copper - therapeutic use</subject><subject>Deficiency Diseases - drug therapy</subject><subject>Deficiency Diseases - metabolism</subject><subject>Erythrocyte Count</subject><subject>Erythrocytes - metabolism</subject><subject>Ferritins - metabolism</subject><subject>Hematocrit</subject><subject>Hemoglobinometry</subject><subject>Iron - blood</subject><subject>Iron - metabolism</subject><subject>Iron - therapeutic use</subject><subject>Kidney - analysis</subject><subject>Liver - analysis</subject><subject>Male</subject><subject>Myocardium - analysis</subject><subject>Rats</subject><subject>Spleen - analysis</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1LAzEQxYMotVZPnoU9iSCrSbZJNkctWiulWqjgLSTZRFL3y2QX9L830lI9eBiG4f14M_MAOEXwCkHGr28fF4gzBCHFe2CIxoykmFK8D4YQQpYiNCaH4CiEdRxzBPkADAjJOOZwCC5mvqmTynRSNaULVeLqRDdta3xaGOu0M3WXeNmFY3BgZRnMybaPwMv93WrykM6fprPJzTzVGcI4RSyzY4wxJZogizXhlKNYisFMGwWNwURJJrniKFcaaW1loSiO11jOVJaNwPnGt_XNR29CJyoXtClLWZumDyKHOY1f8QhebkDtmxC8saL1rpL-SyAofnIRf3KJ9NnWtleVKXbsNoiopxvdhc587mTp3wVlGSOCTpcCL9iS0-dXsfrltayUd8WbEeum93WM5t_935NQeIY</recordid><startdate>1971</startdate><enddate>1971</enddate><creator>Marston, H. R.</creator><creator>Allen, Shirley H.</creator><creator>Swaby, S. L.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1971</creationdate><title>Iron metabolism in copper-deficient rats</title><author>Marston, H. R. ; Allen, Shirley H. ; Swaby, S. 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R.</creatorcontrib><creatorcontrib>Allen, Shirley H.</creatorcontrib><creatorcontrib>Swaby, S. L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marston, H. R.</au><au>Allen, Shirley H.</au><au>Swaby, S. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron metabolism in copper-deficient rats</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>1971</date><risdate>1971</risdate><volume>25</volume><issue>1</issue><spage>15</spage><epage>30</epage><pages>15-30</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>1. The effects of ingestion of diets deficient in both copper and iron on storage of these elements and on the red cell indices have been studied in rats. 2. Injection of Cu into rats whose stores of Cu had been virtually exhausted resulted in a temporary increase in the concentration of plasma Fe and depletion of the Fe stored in the liver. Storage of Fe in the spleen seemed to be affected somewhat differently from that in the liver. 3. Fe injected into Cu-deficient rats was transported to storage sites but, although the plasma Fe concentration was presumably transiently increased thereby, there was no lasting effect. 4. The hypotheses that Cu mediates in the release of Fe from ferritin and that of Osaki, Johnson & Frieden (1966) that caeruloplasmin promotes the rate of Fe-saturation of apotransferrin are discussed.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>5539290</pmid><doi>10.1079/BJN19710062</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-1145 |
| ispartof | British journal of nutrition, 1971, Vol.25 (1), p.15-30 |
| issn | 0007-1145 1475-2662 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Body Weight Bone Marrow - analysis Copper - blood Copper - metabolism Copper - therapeutic use Deficiency Diseases - drug therapy Deficiency Diseases - metabolism Erythrocyte Count Erythrocytes - metabolism Ferritins - metabolism Hematocrit Hemoglobinometry Iron - blood Iron - metabolism Iron - therapeutic use Kidney - analysis Liver - analysis Male Myocardium - analysis Rats Spleen - analysis |
| title | Iron metabolism in copper-deficient rats |
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