Further evidence for oxidative damage to hemoglobin and red cell membrane in leukemia
The presence of significant methemoglobinemia in a large number (79%) of cases of leukemia prompted us to look into the evidence for oxidative injury to the other red cell constituents, e.g. the cell membrane. Forty-five per cent of cases showed increased malonyldialdehyde (MDA) levels indicating in...
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| Veröffentlicht in: | Leukemia research 1983, Vol.7 (6), p.729-733 |
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| container_title | Leukemia research |
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| creator | Pavri, Roshan S. Das Gupta, Amar Baxi, Arvind J. Advani, Suresh H. |
| description | The presence of significant methemoglobinemia in a large number (79%) of cases of leukemia prompted us to look into the evidence for oxidative injury to the other red cell constituents, e.g. the cell membrane. Forty-five per cent of cases showed increased malonyldialdehyde (MDA) levels indicating
in vivo peroxidation of membrane lipids in leukemia patients. Red cell superoxide dismutase (SOD) activity was reduced in 25% of cases while plasma α-tocopherol levels were markedly low in 68% of patients. The presence of an inverse correlation between MDA levels and SOD and tocopherol levels in a large number of cases suggested that the red cells in leukemia lack the ability to counter increased oxidative stress. Low hemoglobin content of the red cells in these patients seemed to contribute to the oxidative injury to the membrane by rendering the latter more accessible to the oxidants. While methemoglobinemia may enhance tissue hypoxia, membrane lipid peroxidation could explain the shortened erythrocyte life-span and anemia in leukemia. |
| doi_str_mv | 10.1016/0145-2126(83)90066-8 |
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in vivo peroxidation of membrane lipids in leukemia patients. Red cell superoxide dismutase (SOD) activity was reduced in 25% of cases while plasma α-tocopherol levels were markedly low in 68% of patients. The presence of an inverse correlation between MDA levels and SOD and tocopherol levels in a large number of cases suggested that the red cells in leukemia lack the ability to counter increased oxidative stress. Low hemoglobin content of the red cells in these patients seemed to contribute to the oxidative injury to the membrane by rendering the latter more accessible to the oxidants. While methemoglobinemia may enhance tissue hypoxia, membrane lipid peroxidation could explain the shortened erythrocyte life-span and anemia in leukemia.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/0145-2126(83)90066-8</identifier><identifier>PMID: 6664097</identifier><identifier>CODEN: LEREDD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>antioxidant levels ; Biological and medical sciences ; Erythrocyte Membrane - metabolism ; erythrocytes ; Erythrocytes - enzymology ; Hematologic and hematopoietic diseases ; Hemoglobins - metabolism ; Humans ; Leukemia ; Leukemia - metabolism ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; lipid peroxidation ; Lipid Peroxides - blood ; Malondialdehyde - blood ; man ; Medical sciences ; membrane damage ; membrane degradation ; methemoglobinemia ; Oxidation-Reduction ; Superoxide Dismutase - analysis ; Vitamin E - blood</subject><ispartof>Leukemia research, 1983, Vol.7 (6), p.729-733</ispartof><rights>1983</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-b46700d392da97d2f06dae5251bd05d6d1b4b7d7218d2a87f2c55f6a76d01b503</citedby><cites>FETCH-LOGICAL-c417t-b46700d392da97d2f06dae5251bd05d6d1b4b7d7218d2a87f2c55f6a76d01b503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0145-2126(83)90066-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9450472$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6664097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pavri, Roshan S.</creatorcontrib><creatorcontrib>Das Gupta, Amar</creatorcontrib><creatorcontrib>Baxi, Arvind J.</creatorcontrib><creatorcontrib>Advani, Suresh H.</creatorcontrib><title>Further evidence for oxidative damage to hemoglobin and red cell membrane in leukemia</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>The presence of significant methemoglobinemia in a large number (79%) of cases of leukemia prompted us to look into the evidence for oxidative injury to the other red cell constituents, e.g. the cell membrane. Forty-five per cent of cases showed increased malonyldialdehyde (MDA) levels indicating
in vivo peroxidation of membrane lipids in leukemia patients. Red cell superoxide dismutase (SOD) activity was reduced in 25% of cases while plasma α-tocopherol levels were markedly low in 68% of patients. The presence of an inverse correlation between MDA levels and SOD and tocopherol levels in a large number of cases suggested that the red cells in leukemia lack the ability to counter increased oxidative stress. Low hemoglobin content of the red cells in these patients seemed to contribute to the oxidative injury to the membrane by rendering the latter more accessible to the oxidants. While methemoglobinemia may enhance tissue hypoxia, membrane lipid peroxidation could explain the shortened erythrocyte life-span and anemia in leukemia.</description><subject>antioxidant levels</subject><subject>Biological and medical sciences</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>erythrocytes</subject><subject>Erythrocytes - enzymology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia - metabolism</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>lipid peroxidation</subject><subject>Lipid Peroxides - blood</subject><subject>Malondialdehyde - blood</subject><subject>man</subject><subject>Medical sciences</subject><subject>membrane damage</subject><subject>membrane degradation</subject><subject>methemoglobinemia</subject><subject>Oxidation-Reduction</subject><subject>Superoxide Dismutase - analysis</subject><subject>Vitamin E - blood</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTuP1DAUhS0EWoaFfwCSC4SgCFzb8SMNElrxklaigdpyfG92Dcl4sZMR_HsSZjQlVC7O5-Ojz4w9FfBagDBvQLS6kUKal0696gCMadw9thPOqkY7pe-z3Rl5yB7V-h0AdCe6C3ZhjGmhszv27cNS5lsqnA4JaR-JD7nw_CthmNOBOIYp3BCfM7-lKd-MuU97HvbICyGPNI58oqkvYU98DUZaftCUwmP2YAhjpSen83J95_3Xq0_N9ZePn6_eXTexFXZu-tZYAFSdxNBZlAMYDKSlFj2CRoOib3uLVgqHMjg7yKj1YII1CKLXoC7Zi2PvXck_F6qzn1LdVq178lK9A6eNUe6_oFCus0qKFWyPYCy51kKDvytpCuW3F-A37X5z6jen3in_V7vf-p-d-pd-IjxfOnle8-enPNQYxmEVFlM9Y12robVyxd4eMVqlHRIVX2PafgVToTh7zOnfO_4A_H2dhQ</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Pavri, Roshan S.</creator><creator>Das Gupta, Amar</creator><creator>Baxi, Arvind J.</creator><creator>Advani, Suresh H.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Further evidence for oxidative damage to hemoglobin and red cell membrane in leukemia</title><author>Pavri, Roshan S. ; Das Gupta, Amar ; Baxi, Arvind J. ; Advani, Suresh H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-b46700d392da97d2f06dae5251bd05d6d1b4b7d7218d2a87f2c55f6a76d01b503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>antioxidant levels</topic><topic>Biological and medical sciences</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>erythrocytes</topic><topic>Erythrocytes - enzymology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemia - metabolism</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>lipid peroxidation</topic><topic>Lipid Peroxides - blood</topic><topic>Malondialdehyde - blood</topic><topic>man</topic><topic>Medical sciences</topic><topic>membrane damage</topic><topic>membrane degradation</topic><topic>methemoglobinemia</topic><topic>Oxidation-Reduction</topic><topic>Superoxide Dismutase - analysis</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pavri, Roshan S.</creatorcontrib><creatorcontrib>Das Gupta, Amar</creatorcontrib><creatorcontrib>Baxi, Arvind J.</creatorcontrib><creatorcontrib>Advani, Suresh H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pavri, Roshan S.</au><au>Das Gupta, Amar</au><au>Baxi, Arvind J.</au><au>Advani, Suresh H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Further evidence for oxidative damage to hemoglobin and red cell membrane in leukemia</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>1983</date><risdate>1983</risdate><volume>7</volume><issue>6</issue><spage>729</spage><epage>733</epage><pages>729-733</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><coden>LEREDD</coden><abstract>The presence of significant methemoglobinemia in a large number (79%) of cases of leukemia prompted us to look into the evidence for oxidative injury to the other red cell constituents, e.g. the cell membrane. Forty-five per cent of cases showed increased malonyldialdehyde (MDA) levels indicating
in vivo peroxidation of membrane lipids in leukemia patients. Red cell superoxide dismutase (SOD) activity was reduced in 25% of cases while plasma α-tocopherol levels were markedly low in 68% of patients. The presence of an inverse correlation between MDA levels and SOD and tocopherol levels in a large number of cases suggested that the red cells in leukemia lack the ability to counter increased oxidative stress. Low hemoglobin content of the red cells in these patients seemed to contribute to the oxidative injury to the membrane by rendering the latter more accessible to the oxidants. While methemoglobinemia may enhance tissue hypoxia, membrane lipid peroxidation could explain the shortened erythrocyte life-span and anemia in leukemia.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>6664097</pmid><doi>10.1016/0145-2126(83)90066-8</doi><tpages>5</tpages></addata></record> |
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| ispartof | Leukemia research, 1983, Vol.7 (6), p.729-733 |
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| subjects | antioxidant levels Biological and medical sciences Erythrocyte Membrane - metabolism erythrocytes Erythrocytes - enzymology Hematologic and hematopoietic diseases Hemoglobins - metabolism Humans Leukemia Leukemia - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis lipid peroxidation Lipid Peroxides - blood Malondialdehyde - blood man Medical sciences membrane damage membrane degradation methemoglobinemia Oxidation-Reduction Superoxide Dismutase - analysis Vitamin E - blood |
| title | Further evidence for oxidative damage to hemoglobin and red cell membrane in leukemia |
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