Corticosteroids in Airway Management

Corticosteroids in Airway Management

Adrenal corticosteroids exert a strong suppressive influence on the basic inflammatory response that leads to tissue swelling. The corticosteroid effect is nonspecific. In upper airway obstruction caused by edema from infection, allergy, or trauma, corticosteroids will exert some degree of suppressi...

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Veröffentlicht in:Otolaryngology-head and neck surgery 1983-12, Vol.91 (6), p.593-596
Hauptverfasser: Hawkins, Donald B, Crockett, Dennis M, Shum, Tony K
Format: Artikel
Sprache:eng
Schlagworte:
Airway Obstruction - drug therapy
Dexamethasone - therapeutic use
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Humans
Infant
Methylprednisolone - therapeutic use
Prednisone - therapeutic use
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container_end_page 596
container_issue 6
container_start_page 593
container_title Otolaryngology-head and neck surgery
container_volume 91
creator Hawkins, Donald B
Crockett, Dennis M
Shum, Tony K
description Adrenal corticosteroids exert a strong suppressive influence on the basic inflammatory response that leads to tissue swelling. The corticosteroid effect is nonspecific. In upper airway obstruction caused by edema from infection, allergy, or trauma, corticosteroids will exert some degree of suppressive effect. The steroid effect is local and directly proportional to the concentration of steroids in the inflamed tissue. In upper airway obstruction steroids should be delivered to the inflamed tissue in high concentration with the least delay. Dexamethasone and methylprednisolone produce high blood levels within 15 to 30 minutes of intramuscular injection. Recommended initial doses for acute airway obstruction are dexamethasone, 1.0 to 1.5 mg/kg, or methylprednisolone, 5 to 7 mg/kg. The risk of harm from steroid therapy of 24 hours or less is negligible.
doi_str_mv 10.1177/019459988309100601
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Airway Obstruction - drug therapy
Dexamethasone - therapeutic use
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Humans
Infant
Methylprednisolone - therapeutic use
Prednisone - therapeutic use
title Corticosteroids in Airway Management
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