Simple sugars inhibit rod outer segment disc shedding by the frog retina
To investigate the hypothesis that sugar molecules might act as markers for ROS disc phagocytosis, frog eyecups were incubated in a normally permissive medium for ROS disc shedding with and without added simple sugars. l-fucose, α-methyl- d-mannopyranoside and d-mannose all significantly reduced the...
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| Veröffentlicht in: | Vision research (Oxford) 1983, Vol.23 (12), p.1371,1377-1375,1377 |
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| container_end_page | 1375,1377 |
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| container_issue | 12 |
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| container_title | Vision research (Oxford) |
| container_volume | 23 |
| creator | Heath, Ashley R. Basinger, Scott F. |
| description | To investigate the hypothesis that sugar molecules might act as markers for ROS disc phagocytosis, frog eyecups were incubated in a normally permissive medium for ROS disc shedding with and without added simple sugars.
l-fucose, α-methyl-
d-mannopyranoside and
d-mannose all significantly reduced the numbers of packets of ROS discs found in the retinal pigment epithelium.
d-fucose,
lmannose,
d-fructose.
d-galactose,
d-glucose and sucrose were without significant effect at the same concentration. Ultrastructural examination of the retinas indicates that the sugars were effective on the disc shedding process rather than on phagocytosis of already shed disc packets. |
| doi_str_mv | 10.1016/0042-6989(83)90148-7 |
| format | Article |
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l-fucose, α-methyl-
d-mannopyranoside and
d-mannose all significantly reduced the numbers of packets of ROS discs found in the retinal pigment epithelium.
d-fucose,
lmannose,
d-fructose.
d-galactose,
d-glucose and sucrose were without significant effect at the same concentration. Ultrastructural examination of the retinas indicates that the sugars were effective on the disc shedding process rather than on phagocytosis of already shed disc packets.</description><identifier>ISSN: 0042-6989</identifier><identifier>EISSN: 1878-5646</identifier><identifier>DOI: 10.1016/0042-6989(83)90148-7</identifier><identifier>PMID: 6607567</identifier><identifier>CODEN: VISRAM</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Electroretinography ; Eye and associated structures. Visual pathways and centers. Vision ; Frog ; Fucose - pharmacology ; Fundamental and applied biological sciences. Psychology ; Hexoses - pharmacology ; In vitro ; In Vitro Techniques ; Mannose - pharmacology ; Methylmannosides - pharmacology ; Microscopy, Electron ; Phagocytosis - drug effects ; Photoreceptor Cells - physiology ; Pigment Epithelium of Eye - physiology ; Rana pipiens ; Rod Cell Outer Segment - drug effects ; Rod Cell Outer Segment - physiology ; Rod Cell Outer Segment - ultrastructure ; ROS shedding ; Sugars ; Vertebrates: nervous system and sense organs</subject><ispartof>Vision research (Oxford), 1983, Vol.23 (12), p.1371,1377-1375,1377</ispartof><rights>1983 Pergamon Press Ltd</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-42c36541a1e4ff8af15359a1c167fe42d8d7cd9b9d63a9350c145dd9da67fb9f3</citedby><cites>FETCH-LOGICAL-c417t-42c36541a1e4ff8af15359a1c167fe42d8d7cd9b9d63a9350c145dd9da67fb9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0042-6989(83)90148-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9423924$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6607567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heath, Ashley R.</creatorcontrib><creatorcontrib>Basinger, Scott F.</creatorcontrib><title>Simple sugars inhibit rod outer segment disc shedding by the frog retina</title><title>Vision research (Oxford)</title><addtitle>Vision Res</addtitle><description>To investigate the hypothesis that sugar molecules might act as markers for ROS disc phagocytosis, frog eyecups were incubated in a normally permissive medium for ROS disc shedding with and without added simple sugars.
l-fucose, α-methyl-
d-mannopyranoside and
d-mannose all significantly reduced the numbers of packets of ROS discs found in the retinal pigment epithelium.
d-fucose,
lmannose,
d-fructose.
d-galactose,
d-glucose and sucrose were without significant effect at the same concentration. Ultrastructural examination of the retinas indicates that the sugars were effective on the disc shedding process rather than on phagocytosis of already shed disc packets.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Electroretinography</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Frog</subject><subject>Fucose - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hexoses - pharmacology</subject><subject>In vitro</subject><subject>In Vitro Techniques</subject><subject>Mannose - pharmacology</subject><subject>Methylmannosides - pharmacology</subject><subject>Microscopy, Electron</subject><subject>Phagocytosis - drug effects</subject><subject>Photoreceptor Cells - physiology</subject><subject>Pigment Epithelium of Eye - physiology</subject><subject>Rana pipiens</subject><subject>Rod Cell Outer Segment - drug effects</subject><subject>Rod Cell Outer Segment - physiology</subject><subject>Rod Cell Outer Segment - ultrastructure</subject><subject>ROS shedding</subject><subject>Sugars</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0042-6989</issn><issn>1878-5646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1KLDEQhYMoOld9A4UsRK6L1qSTzs9GELlXBcGFug7ppDIT6Z8x6RZ8e3ucYZa6qoLznaL4EDqh5JISKq4I4WUhtNJ_FbvQhHJVyB00o0qqohJc7KLZFjlAf3J-I4TIqtT7aF-IaRNyhu6fY7tsAOdxblPGsVvEOg449R734wAJZ5i30A3Yx-xwXoD3sZvj-hMPC8Ah9XOcYIidPUJ7wTYZjjfzEL3-__dye188Pt093N48Fo5TORS8dExUnFoKPARlA61YpS11VMgAvPTKS-d1rb1gVrOKOMor77W3U17rwA7R-fruMvXvI-TBtNNn0DS2g37MRhFVccHpryBlipWSkQnka9ClPucEwSxTbG36NJSYlWmz0mhWGo1i5tu0kVPtdHN_rFvw29JG7ZSfbXKbnW1Csp2LeYtpXjJd8gm7XmMwSfuIkEx2EToHPiZwg_F9_PmPL5ramYA</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Heath, Ashley R.</creator><creator>Basinger, Scott F.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Simple sugars inhibit rod outer segment disc shedding by the frog retina</title><author>Heath, Ashley R. ; Basinger, Scott F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-42c36541a1e4ff8af15359a1c167fe42d8d7cd9b9d63a9350c145dd9da67fb9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Electroretinography</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Frog</topic><topic>Fucose - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hexoses - pharmacology</topic><topic>In vitro</topic><topic>In Vitro Techniques</topic><topic>Mannose - pharmacology</topic><topic>Methylmannosides - pharmacology</topic><topic>Microscopy, Electron</topic><topic>Phagocytosis - drug effects</topic><topic>Photoreceptor Cells - physiology</topic><topic>Pigment Epithelium of Eye - physiology</topic><topic>Rana pipiens</topic><topic>Rod Cell Outer Segment - drug effects</topic><topic>Rod Cell Outer Segment - physiology</topic><topic>Rod Cell Outer Segment - ultrastructure</topic><topic>ROS shedding</topic><topic>Sugars</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heath, Ashley R.</creatorcontrib><creatorcontrib>Basinger, Scott F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vision research (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heath, Ashley R.</au><au>Basinger, Scott F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simple sugars inhibit rod outer segment disc shedding by the frog retina</atitle><jtitle>Vision research (Oxford)</jtitle><addtitle>Vision Res</addtitle><date>1983</date><risdate>1983</risdate><volume>23</volume><issue>12</issue><spage>1371,1377</spage><epage>1375,1377</epage><pages>1371,1377-1375,1377</pages><issn>0042-6989</issn><eissn>1878-5646</eissn><coden>VISRAM</coden><abstract>To investigate the hypothesis that sugar molecules might act as markers for ROS disc phagocytosis, frog eyecups were incubated in a normally permissive medium for ROS disc shedding with and without added simple sugars.
l-fucose, α-methyl-
d-mannopyranoside and
d-mannose all significantly reduced the numbers of packets of ROS discs found in the retinal pigment epithelium.
d-fucose,
lmannose,
d-fructose.
d-galactose,
d-glucose and sucrose were without significant effect at the same concentration. Ultrastructural examination of the retinas indicates that the sugars were effective on the disc shedding process rather than on phagocytosis of already shed disc packets.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>6607567</pmid><doi>10.1016/0042-6989(83)90148-7</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0042-6989 |
| ispartof | Vision research (Oxford), 1983, Vol.23 (12), p.1371,1377-1375,1377 |
| issn | 0042-6989 1878-5646 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Electroretinography Eye and associated structures. Visual pathways and centers. Vision Frog Fucose - pharmacology Fundamental and applied biological sciences. Psychology Hexoses - pharmacology In vitro In Vitro Techniques Mannose - pharmacology Methylmannosides - pharmacology Microscopy, Electron Phagocytosis - drug effects Photoreceptor Cells - physiology Pigment Epithelium of Eye - physiology Rana pipiens Rod Cell Outer Segment - drug effects Rod Cell Outer Segment - physiology Rod Cell Outer Segment - ultrastructure ROS shedding Sugars Vertebrates: nervous system and sense organs |
| title | Simple sugars inhibit rod outer segment disc shedding by the frog retina |
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