Helper T-cell deficiency in infantile genetic agranulocytosis (M. Kostmann)
A female turkish infant with congenital infantile genetic agranulocytosis was examined for its distribution of lymphocyte subclasses. Imbalances of B cells and T-cell subpopulations were found. Compared to the normal control group a relative as well as an absolute deficiency of T helper cells and an...
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| Veröffentlicht in: | Monatsschrift Kinderheilkunde 1983-11, Vol.131 (11), p.793-796 |
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| container_title | Monatsschrift Kinderheilkunde |
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| creator | Evers, K G Burdach, S E Ieromnimon, W Krüger, J |
| description | A female turkish infant with congenital infantile genetic agranulocytosis was examined for its distribution of lymphocyte subclasses. Imbalances of B cells and T-cell subpopulations were found. Compared to the normal control group a relative as well as an absolute deficiency of T helper cells and an increase of the absolute number of T suppressor cells were the most prominent findings. The importance of immunoregulatory T-cell subsets in the pathogenesis of infantile genetic agranulocytosis, disorders of hematopoiesis and granulocyte production, as well as primary and secondary immunodeficiencies is discussed. |
| format | Article |
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| identifier | ISSN: 0026-9298 |
| ispartof | Monatsschrift Kinderheilkunde, 1983-11, Vol.131 (11), p.793-796 |
| issn | 0026-9298 |
| language | ger |
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| source | MEDLINE; SpringerNature Complete Journals |
| subjects | Agranulocytosis - complications Agranulocytosis - congenital Consanguinity Female Humans Infant Lymphocytosis - complications Lymphopenia - complications T-Lymphocytes, Helper-Inducer T-Lymphocytes, Regulatory |
| title | Helper T-cell deficiency in infantile genetic agranulocytosis (M. Kostmann) |
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