Renin and erythropoietin release in renal allotransplantation states

Erythropoietin (ESF) and renin assays were serially performed in untreated and azathioprine‐treated dog renal allografts. ESF levels accurately reflected the progressive decline in renal function, and degree of allograft rejection. ESF elevations did not correlate with the level of hematocrit, or degree of azotemia or hypertension. Renin levels, in contrast, were elevated to a variable and less marked degree and did not correlate with the level of hypertension, decline in renal function, degree of allograft rejection, or level of increased erythropoietin. ESF assays proved to be more accurate and reliable.