The southwest oncology group experience: adjuvant therapy for stage IB and II non-seminomatous testicular cancer
During a two year period, 65 patients with Stage II non-seminomatous testis cancer were randomized to receive adjuvant chemotherapy and radiation. Of the 52 evaluable patients, 23 received radiation followed by chemotherapy (sequential), and 29 received the same chemotherapy as initial treatment, bu...
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| Veröffentlicht in: | Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1983-12, Vol.9 (12), p.1885-1890 |
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| container_issue | 12 |
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| container_title | Int. J. Radiat. Oncol., Biol. Phys.; (United States) |
| container_volume | 9 |
| creator | Stephens, Ronald L. Eltringham, James R. Coltman, Charles A. Neidhart, James Mullins, James Frank, Jess |
| description | During a two year period, 65 patients with Stage II non-seminomatous testis cancer were randomized to receive adjuvant chemotherapy and radiation. Of the 52 evaluable patients, 23 received radiation followed by chemotherapy (sequential), and 29 received the same chemotherapy as initial treatment, but had drug treatment temporarily interrupted for radiation (sandwich). The combined treatment was well tolerated, but did not eliminate recurrence. With regard to duration of survival and disease-free survival, no statistically significant difference could be found between the sequential and sandwich approaches. |
| doi_str_mv | 10.1016/0360-3016(83)90357-7 |
| format | Article |
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Of the 52 evaluable patients, 23 received radiation followed by chemotherapy (sequential), and 29 received the same chemotherapy as initial treatment, but had drug treatment temporarily interrupted for radiation (sandwich). The combined treatment was well tolerated, but did not eliminate recurrence. With regard to duration of survival and disease-free survival, no statistically significant difference could be found between the sequential and sandwich approaches.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/0360-3016(83)90357-7</identifier><identifier>PMID: 6198313</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>550603 - Medicine- External Radiation in Therapy- (1980-) ; 560151 - Radiation Effects on Animals- Man ; Adjuvant treatment ; Adult ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; Biological and medical sciences ; Bleomycin - administration & dosage ; BODY ; CHEMOTHERAPY ; COBALT 60 ; COBALT ISOTOPES ; Combined Modality Therapy ; DISEASES ; ELECTROMAGNETIC RADIATION ; GAMMA RADIATION ; GONADS ; Gynecology. Andrology. Obstetrics ; HARD X RADIATION ; HEMIC DISEASES ; Humans ; INTERMEDIATE MASS NUCLEI ; INTERNAL CONVERSION RADIOISOTOPES ; IONIZING RADIATIONS ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; LEUKOPENIA ; Male ; Male genital diseases ; MALE GENITALS ; Medical sciences ; MEDICINE ; Middle Aged ; MINUTES LIVING RADIOISOTOPES ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Recurrence, Local - therapy ; Neoplasm Staging ; NEOPLASMS ; NUCLEAR MEDICINE ; NUCLEI ; ODD-ODD NUCLEI ; ORGANS ; PATIENTS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIATIONS ; RADIOINDUCTION ; RADIOISOTOPES ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Radiotherapy Dosage ; Random Allocation ; SIDE EFFECTS ; TESTES ; Testicular Neoplasms - mortality ; Testicular Neoplasms - pathology ; Testicular Neoplasms - therapy ; Testis cancer ; THERAPY ; Time Factors ; Tumors ; United States ; Vinblastine - administration & dosage ; X RADIATION ; YEARS LIVING RADIOISOTOPES</subject><ispartof>Int. J. Radiat. Oncol., Biol. 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J. Radiat. Oncol., Biol. Phys.; (United States)</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>During a two year period, 65 patients with Stage II non-seminomatous testis cancer were randomized to receive adjuvant chemotherapy and radiation. Of the 52 evaluable patients, 23 received radiation followed by chemotherapy (sequential), and 29 received the same chemotherapy as initial treatment, but had drug treatment temporarily interrupted for radiation (sandwich). The combined treatment was well tolerated, but did not eliminate recurrence. With regard to duration of survival and disease-free survival, no statistically significant difference could be found between the sequential and sandwich approaches.</description><subject>550603 - Medicine- External Radiation in Therapy- (1980-)</subject><subject>560151 - Radiation Effects on Animals- Man</subject><subject>Adjuvant treatment</subject><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>Bleomycin - administration & dosage</subject><subject>BODY</subject><subject>CHEMOTHERAPY</subject><subject>COBALT 60</subject><subject>COBALT ISOTOPES</subject><subject>Combined Modality Therapy</subject><subject>DISEASES</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>GAMMA RADIATION</subject><subject>GONADS</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>HARD X RADIATION</subject><subject>HEMIC DISEASES</subject><subject>Humans</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>INTERNAL CONVERSION RADIOISOTOPES</subject><subject>IONIZING RADIATIONS</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>LEUKOPENIA</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>MALE GENITALS</subject><subject>Medical sciences</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>MINUTES LIVING RADIOISOTOPES</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neoplasm Recurrence, Local - therapy</subject><subject>Neoplasm Staging</subject><subject>NEOPLASMS</subject><subject>NUCLEAR MEDICINE</subject><subject>NUCLEI</subject><subject>ODD-ODD NUCLEI</subject><subject>ORGANS</subject><subject>PATIENTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIATIONS</subject><subject>RADIOINDUCTION</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy Dosage</subject><subject>Random Allocation</subject><subject>SIDE EFFECTS</subject><subject>TESTES</subject><subject>Testicular Neoplasms - mortality</subject><subject>Testicular Neoplasms - pathology</subject><subject>Testicular Neoplasms - therapy</subject><subject>Testis cancer</subject><subject>THERAPY</subject><subject>Time Factors</subject><subject>Tumors</subject><subject>United States</subject><subject>Vinblastine - administration & dosage</subject><subject>X RADIATION</subject><subject>YEARS LIVING RADIOISOTOPES</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2LFDEQxYMo67j6HygEEdFDa2XSH2kPgi5-DCx4WcFbqE6qZ3rpSXqT9Or896adYY6eEqhfPV69x9hzAe8EiPo9yBoKmX9vlHzbgqyaonnAVkI1bSGr6tdDtjojj9mTGG8BQIimvGAXtWiVFHLFppsd8ejntPtNMXHvjB_99sC3wc8Tpz8ThYGcoQ8c7e18jy7xtKOA04H3PvCYcEt885mjs3yz4c67ItJ-cH6Pyc-Rp6w6mHnEwA1mnfCUPepxjPTs9F6yn1-_3Fx9L65_fNtcfboujFyrVPQtKqSWUJWV6moka00nqh47W5q6UkoiVrXsJdXrHkprGtuB7GvoRGOB1vKSvTzq-mxARzMkMjvjnSOTdAUCSgUZen2EpuDv5mxV74doaBzRUXavFahSCbWolUfQBB9joF5PYdhjOGgBemlDL1HrJWqtpP7Xhm7y2ouT_tztyZ6XTvHn-avTHKPBsQ85oiGesbYBKKHM2McjRjmw-4HCcs_Sih3Cco71w_99_AXlqafW</recordid><startdate>198312</startdate><enddate>198312</enddate><creator>Stephens, Ronald L.</creator><creator>Eltringham, James R.</creator><creator>Coltman, Charles A.</creator><creator>Neidhart, James</creator><creator>Mullins, James</creator><creator>Frank, Jess</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198312</creationdate><title>The southwest oncology group experience: adjuvant therapy for stage IB and II non-seminomatous testicular cancer</title><author>Stephens, Ronald L. ; Eltringham, James R. ; Coltman, Charles A. ; Neidhart, James ; Mullins, James ; Frank, Jess</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-f9a8ae9ea8458b6aeddcb15fabd4c65883aa563f3e62f04dc7db03f60b17d0e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>550603 - Medicine- External Radiation in Therapy- (1980-)</topic><topic>560151 - Radiation Effects on Animals- Man</topic><topic>Adjuvant treatment</topic><topic>Adult</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>Bleomycin - administration & dosage</topic><topic>BODY</topic><topic>CHEMOTHERAPY</topic><topic>COBALT 60</topic><topic>COBALT ISOTOPES</topic><topic>Combined Modality Therapy</topic><topic>DISEASES</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>GAMMA RADIATION</topic><topic>GONADS</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>HARD X RADIATION</topic><topic>HEMIC DISEASES</topic><topic>Humans</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>INTERNAL CONVERSION RADIOISOTOPES</topic><topic>IONIZING RADIATIONS</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>LEUKOPENIA</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>MALE GENITALS</topic><topic>Medical sciences</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>MINUTES LIVING RADIOISOTOPES</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neoplasm Recurrence, Local - therapy</topic><topic>Neoplasm Staging</topic><topic>NEOPLASMS</topic><topic>NUCLEAR MEDICINE</topic><topic>NUCLEI</topic><topic>ODD-ODD NUCLEI</topic><topic>ORGANS</topic><topic>PATIENTS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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Phys.; (United States)</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>1983-12</date><risdate>1983</risdate><volume>9</volume><issue>12</issue><spage>1885</spage><epage>1890</epage><pages>1885-1890</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>During a two year period, 65 patients with Stage II non-seminomatous testis cancer were randomized to receive adjuvant chemotherapy and radiation. Of the 52 evaluable patients, 23 received radiation followed by chemotherapy (sequential), and 29 received the same chemotherapy as initial treatment, but had drug treatment temporarily interrupted for radiation (sandwich). The combined treatment was well tolerated, but did not eliminate recurrence. With regard to duration of survival and disease-free survival, no statistically significant difference could be found between the sequential and sandwich approaches.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6198313</pmid><doi>10.1016/0360-3016(83)90357-7</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-3016 |
| ispartof | Int. J. Radiat. Oncol., Biol. Phys.; (United States), 1983-12, Vol.9 (12), p.1885-1890 |
| issn | 0360-3016 1879-355X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80848182 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 550603 - Medicine- External Radiation in Therapy- (1980-) 560151 - Radiation Effects on Animals- Man Adjuvant treatment Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences Bleomycin - administration & dosage BODY CHEMOTHERAPY COBALT 60 COBALT ISOTOPES Combined Modality Therapy DISEASES ELECTROMAGNETIC RADIATION GAMMA RADIATION GONADS Gynecology. Andrology. Obstetrics HARD X RADIATION HEMIC DISEASES Humans INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES IONIZING RADIATIONS ISOMERIC TRANSITION ISOTOPES ISOTOPES LEUKOPENIA Male Male genital diseases MALE GENITALS Medical sciences MEDICINE Middle Aged MINUTES LIVING RADIOISOTOPES Neoplasm Recurrence, Local - epidemiology Neoplasm Recurrence, Local - therapy Neoplasm Staging NEOPLASMS NUCLEAR MEDICINE NUCLEI ODD-ODD NUCLEI ORGANS PATIENTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOINDUCTION RADIOISOTOPES RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Random Allocation SIDE EFFECTS TESTES Testicular Neoplasms - mortality Testicular Neoplasms - pathology Testicular Neoplasms - therapy Testis cancer THERAPY Time Factors Tumors United States Vinblastine - administration & dosage X RADIATION YEARS LIVING RADIOISOTOPES |
| title | The southwest oncology group experience: adjuvant therapy for stage IB and II non-seminomatous testicular cancer |
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