Validation of Computational Fluid Dynamics in CT-based Airway Models with SPECT/CT
To compare the results obtained by using numerical flow simulations with the results of combined single photon emission computed tomography (SPECT) and computed tomography (CT) and to demonstrate the importance of correct boundary conditions for the numerical methods to account for the large amount...
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| Veröffentlicht in: | Radiology 2010-12, Vol.257 (3), p.854-862 |
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| creator | DE BACKER, Jan W VOS, Wim G VINCHURKAR, Samir C CLAES, Rita DROLLMANN, Anton WULFRANK, Denis PARIZEL, Paul M GERMONPRE, Paul DE BACKER, Wilfried |
| description | To compare the results obtained by using numerical flow simulations with the results of combined single photon emission computed tomography (SPECT) and computed tomography (CT) and to demonstrate the importance of correct boundary conditions for the numerical methods to account for the large amount of interpatient variability in airway geometry.
This study was approved by all relevant institutional review boards. All patients gave their signed informed consent. In this study, six patients with mild asthma (three men; three women; overall mean age, 46 years ± 17 [standard deviation]) underwent CT at functional residual capacity and total lung capacity, as well as SPECT/CT. CT data were used for segmentation and computational fluid dynamics (CFD) simulations. A comparison was made between airflow distribution, as derived with (a) SPECT/CT through tracer concentration analysis, (b) CT through lobar expansion measurement, and (c) CFD through flow computer simulation. Also, the heterogeneity of the ventilation was examined.
Good agreement was found between SPECT/CT, CT, and CFD in terms of airflow distribution and hot spot detection. The average difference for the internal airflow distribution was less than 3% for CFD and CT versus SPECT/CT. Heterogeneity in ventilation patterns could be detected with SPECT/CT and CFD.
This results of this study show that patient-specific computer simulations with appropriate boundary conditions yield information that is similar to that obtained with functional imaging tools, such as SPECT/CT.
http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100322/-/DC1. |
| doi_str_mv | 10.1148/radiol.10100322 |
| format | Article |
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This study was approved by all relevant institutional review boards. All patients gave their signed informed consent. In this study, six patients with mild asthma (three men; three women; overall mean age, 46 years ± 17 [standard deviation]) underwent CT at functional residual capacity and total lung capacity, as well as SPECT/CT. CT data were used for segmentation and computational fluid dynamics (CFD) simulations. A comparison was made between airflow distribution, as derived with (a) SPECT/CT through tracer concentration analysis, (b) CT through lobar expansion measurement, and (c) CFD through flow computer simulation. Also, the heterogeneity of the ventilation was examined.
Good agreement was found between SPECT/CT, CT, and CFD in terms of airflow distribution and hot spot detection. The average difference for the internal airflow distribution was less than 3% for CFD and CT versus SPECT/CT. Heterogeneity in ventilation patterns could be detected with SPECT/CT and CFD.
This results of this study show that patient-specific computer simulations with appropriate boundary conditions yield information that is similar to that obtained with functional imaging tools, such as SPECT/CT.
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This study was approved by all relevant institutional review boards. All patients gave their signed informed consent. In this study, six patients with mild asthma (three men; three women; overall mean age, 46 years ± 17 [standard deviation]) underwent CT at functional residual capacity and total lung capacity, as well as SPECT/CT. CT data were used for segmentation and computational fluid dynamics (CFD) simulations. A comparison was made between airflow distribution, as derived with (a) SPECT/CT through tracer concentration analysis, (b) CT through lobar expansion measurement, and (c) CFD through flow computer simulation. Also, the heterogeneity of the ventilation was examined.
Good agreement was found between SPECT/CT, CT, and CFD in terms of airflow distribution and hot spot detection. The average difference for the internal airflow distribution was less than 3% for CFD and CT versus SPECT/CT. Heterogeneity in ventilation patterns could be detected with SPECT/CT and CFD.
This results of this study show that patient-specific computer simulations with appropriate boundary conditions yield information that is similar to that obtained with functional imaging tools, such as SPECT/CT.
http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100322/-/DC1.</description><subject>Adult</subject><subject>Aerosols - administration & dosage</subject><subject>Aged</subject><subject>Asthma - diagnostic imaging</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Computerized, statistical medical data processing and models in biomedicine</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models and simulation</subject><subject>Models, Anatomic</subject><subject>Pneumology</subject><subject>Radiographic Image Interpretation, Computer-Assisted</subject><subject>Radiopharmaceuticals - administration & dosage</subject><subject>Respiratory Function Tests</subject><subject>Software</subject><subject>Technetium Tc 99m Pentetate - administration & dosage</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Tomography, X-Ray Computed</subject><issn>0033-8419</issn><issn>1527-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRbK2evclexFPa_Uiym2OJrQoVRaPXMNnd4MomqdmE0n9vtK2ehhme94V5ELqkZEppKGctaNu4KSWUEM7YERrTiImAchodo_Fw44EMaTJCZ95_EkLDSIpTNGKUyDCkYoxe3sFZDZ1tatyUOG2qdd_9ruDw0vVW49ttDZVVHtsap1lQgDcaz227gS1-bLRxHm9s94FfnxdpNkuzc3RSgvPmYj8n6G25yNL7YPV095DOV4HiseiCJIwjXjLDC81BCQZcRaVQTJcypoYRIZMi0ZxwoTUvSFkUXIIOtY4LCYk2fIJudr3rtvnqje_yynplnIPaNL3P5fBjHMUiGcjZjlRt431rynzd2grabU5J_uMx33nMDx6HxNW-uy8qo__4g7gBuN4D4BW4soVaWf_P8ZCRKOb8G0hSe5w</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>DE BACKER, Jan W</creator><creator>VOS, Wim G</creator><creator>VINCHURKAR, Samir C</creator><creator>CLAES, Rita</creator><creator>DROLLMANN, Anton</creator><creator>WULFRANK, Denis</creator><creator>PARIZEL, Paul M</creator><creator>GERMONPRE, Paul</creator><creator>DE BACKER, Wilfried</creator><general>Radiological Society of North America</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Validation of Computational Fluid Dynamics in CT-based Airway Models with SPECT/CT</title><author>DE BACKER, Jan W ; 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This study was approved by all relevant institutional review boards. All patients gave their signed informed consent. In this study, six patients with mild asthma (three men; three women; overall mean age, 46 years ± 17 [standard deviation]) underwent CT at functional residual capacity and total lung capacity, as well as SPECT/CT. CT data were used for segmentation and computational fluid dynamics (CFD) simulations. A comparison was made between airflow distribution, as derived with (a) SPECT/CT through tracer concentration analysis, (b) CT through lobar expansion measurement, and (c) CFD through flow computer simulation. Also, the heterogeneity of the ventilation was examined.
Good agreement was found between SPECT/CT, CT, and CFD in terms of airflow distribution and hot spot detection. The average difference for the internal airflow distribution was less than 3% for CFD and CT versus SPECT/CT. Heterogeneity in ventilation patterns could be detected with SPECT/CT and CFD.
This results of this study show that patient-specific computer simulations with appropriate boundary conditions yield information that is similar to that obtained with functional imaging tools, such as SPECT/CT.
http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.10100322/-/DC1.</abstract><cop>Oak Brook, IL</cop><pub>Radiological Society of North America</pub><pmid>21084417</pmid><doi>10.1148/radiol.10100322</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Radiology, 2010-12, Vol.257 (3), p.854-862 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aerosols - administration & dosage Aged Asthma - diagnostic imaging Asthma - physiopathology Biological and medical sciences Chronic obstructive pulmonary disease, asthma Computerized, statistical medical data processing and models in biomedicine Female Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Models and simulation Models, Anatomic Pneumology Radiographic Image Interpretation, Computer-Assisted Radiopharmaceuticals - administration & dosage Respiratory Function Tests Software Technetium Tc 99m Pentetate - administration & dosage Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed |
| title | Validation of Computational Fluid Dynamics in CT-based Airway Models with SPECT/CT |
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