Design of Three-Component Vaccines against Group A Streptococcal Infections: Importance of Spatial Arrangement of Vaccine Components

Immunological assessment of group A streptococcal (GAS) branched lipopeptides demonstrated the impact of spatial arrangement of vaccine components on both the quality and quantity of their immune responses. Each lipopeptide was composed of three components: a GAS B-cell epitope (J14), a universal CD...

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Veröffentlicht in:	Journal of medicinal chemistry 2010-11, Vol.53 (22), p.8041-8046
Hauptverfasser:	Abdel-Aal, Abu-Baker M, Zaman, Mehfuz, Fujita, Yoshio, Batzloff, Michael R, Good, Michael F, Toth, Istvan
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Epitopes, B-Lymphocyte Epitopes, T-Lymphocyte Female Lipopeptides - administration & dosage Lipopeptides - chemistry Lipopeptides - immunology Mice Protein Structure, Secondary Streptococcal Infections - immunology Streptococcal Infections - prevention & control Streptococcal Vaccines - administration & dosage Streptococcal Vaccines - chemistry Streptococcal Vaccines - immunology Streptococcus pyogenes - immunology Vaccines, Subunit - administration & dosage Vaccines, Subunit - chemistry Vaccines, Subunit - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - chemistry Vaccines, Synthetic - immunology
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