Asymmetric Bromolactonization Catalyzed by a C₃‐Symmetric Chiral Trisimidazoline

A productive alliance: In an enantioselective organocatalytic bromolactonization of 5‐substituted hex‐5‐enoic acids (see scheme), it appears that the formation of an ion pair through interaction of the trisimidazoline catalyst 1 with the substrate both creates a chiral environment and promotes the c...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2010-11, Vol.49 (48), p.9174-9177
Hauptverfasser:	Murai, Kenichi, Matsushita, Tomoyo, Nakamura, Akira, Fukushima, Shunsuke, Shimura, Masato, Fujioka, Hiromichi
Format:	Artikel
Sprache:	eng
Schlagworte:	asymmetric synthesis Bromine - chemistry Catalysis halogenation Heterocyclic Compounds - chemistry imidazolines Imidazolines - chemistry lactones Lactones - chemistry Magnetic Resonance Spectroscopy organocatalysis Stereoisomerism
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