Adaptation to a High-Tungsten Environment: Pyrobaculum aerophilum Contains an Active Tungsten Nitrate Reductase

Nitrate reductases (Nars) belong to the DMSO reductase family of molybdoenzymes. The hyperthermophilic denitrifying archaeon Pyrobaculum aerophilum exhibits nitrate reductase (Nar) activity even at WO4 2− concentrations that are inhibitory to bacterial Nars. In this report, we establish that the enz...

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Veröffentlicht in:	Biochemistry (Easton) 2010-11, Vol.49 (45), p.9911-9921
Hauptverfasser:	de Vries, Simon, Momcilovic, Milica, Strampraad, Marc J. F, Whitelegge, Julian P, Baghai, Ashkan, Schröder, Imke
Format:	Artikel
Sprache:	eng
Schlagworte:	Acclimatization Catalytic Domain Electron Spin Resonance Spectroscopy Environment Kinetics Mass Spectrometry Nitrate Reductase - isolation & purification Nitrate Reductase - metabolism Nitrite Reductases - isolation & purification Nitrite Reductases - metabolism Oxidation-Reduction Protein Subunits - isolation & purification Protein Subunits - metabolism Pyrobaculum - drug effects Pyrobaculum - enzymology Pyrobaculum - growth & development Tungsten - metabolism Tungsten - pharmacology
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