Involvement of Carboxylesterase 1 and 2 in the Hydrolysis of Mycophenolate Mofetil

Mycophenolate mofetil (MMF) is the ester prodrug of the immunosuppressant agent mycophenolic acid (MPA) and is rapidly activated by esterases after oral administration. However, the role of isoenzymes in MMF hydrolysis remains unclear. Although human plasma, erythrocytes, and whole blood contain MMF...

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Veröffentlicht in:	Drug metabolism and disposition 2010-12, Vol.38 (12), p.2210-2217
Hauptverfasser:	Fujiyama, Nobuhiro, Miura, Masatomo, Kato, Shoutaro, Sone, Tomomichi, Isobe, Masakazu, Satoh, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Biological and medical sciences Carboxylesterase - physiology Carboxylic Ester Hydrolases - physiology Cercopithecus aethiops COS Cells Female Humans Hydrolysis Immunosuppressive Agents - metabolism Male Medical sciences Middle Aged Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - metabolism Pharmacology. Drug treatments Recombinant Proteins - metabolism
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