Genetic mapping of quantitative trait loci for milk production in sheep
A backcross pedigree using dairy East Friesian rams and non-dairy Dorset ewes was established specifically to map quantitative trait loci (QTL) affecting milk production in sheep. Ninety nine microsatellite markers of an initial set of 120 were successfully genotyped and informative on 188 animals o...
Gespeichert in:
| Veröffentlicht in: | Animal genetics 2010-10, Vol.41 (5), p.460-466 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 466 |
|---|---|
| container_issue | 5 |
| container_start_page | 460 |
| container_title | Animal genetics |
| container_volume | 41 |
| creator | Mateescu, R.G Thonney, M.L |
| description | A backcross pedigree using dairy East Friesian rams and non-dairy Dorset ewes was established specifically to map quantitative trait loci (QTL) affecting milk production in sheep. Ninety nine microsatellite markers of an initial set of 120 were successfully genotyped and informative on 188 animals of this backcross pedigree. Test-day milk records on individual ewes were used to estimate several milk yield related traits, including peak milk yield and cumulative milk yield to 50 (MY50), 100 (MY100) and 250 days (MY250). These traits, as well as estimated breeding value of backcross ewes extracted from the genetic evaluation file of the entire flock, were used in interval mapping. Ovine chromosomes 2, 12, 18, 20 and 24 were identified to harbour putative QTL for different measures of milk production. The QTL on Ovis aries chromosomes (OAR) 2 and 20 mapped to locations where similar trait QTL have already been mapped in other studies, whereas QTL on OAR 12, 18 and 24 were unique to our backcross pedigree and have not been reported previously. In addition, all identified QTL regions were syntenic with bovine chromosomal segments revealed to harbour QTL affecting milk production traits, providing supporting evidence for the QTL identified here. |
| doi_str_mv | 10.1111/j.1365-2052.2010.02045.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_808459022</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>808459022</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4905-28a0b5f3100e5922b1a1c564327a076102d6b46948e223a6bae56de748aefc7f3</originalsourceid><addsrcrecordid>eNqNkU9v1DAQxS0EokvhK4AlDpyyjP_GOXCoViWAWjhABbeRk3WKt9kktRPYfnscUvbABXyxZf_em_E8QiiDNUvr9W7NhFYZB8XXHNItcJBqfXhAVseHh2QFXJusYFKfkCcx7gDAsJw9JiccRCE1iBUpS9e50dd0b4fBd9e0b-jtZLvRj3b0Pxwdg_Ujbfva06YPdO_bGzqEfjvVo-876jsavzs3PCWPGttG9-x-PyVXb8-_bN5lF5_K95uzi6yWBaTGjIVKNYIBOFVwXjHLaqWl4LmFXDPgW11JXUjjOBdWV9YpvXW5NNY1dd6IU_Jq8U093E4ujrj3sXZtazvXTxENGKkKSOJ_kbnmPOeS6US-_Ivc9VPo0jeQKam4MaJgiTILVYc-xuAaHILf23CHDHBOBXc4Dx_n4eOcCv5OBQ9J-vy-wFTt3fYo_BNDAt4swE_furv_Nsaz8nw-JX226H0c3eGot-EGdS5yhV8_lvhhw75dFvwSZeJfLHxje7TXwUe8-pycBTBjtEgd_QL_HrCa</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1545288391</pqid></control><display><type>article</type><title>Genetic mapping of quantitative trait loci for milk production in sheep</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Mateescu, R.G ; Thonney, M.L</creator><creatorcontrib>Mateescu, R.G ; Thonney, M.L</creatorcontrib><description>A backcross pedigree using dairy East Friesian rams and non-dairy Dorset ewes was established specifically to map quantitative trait loci (QTL) affecting milk production in sheep. Ninety nine microsatellite markers of an initial set of 120 were successfully genotyped and informative on 188 animals of this backcross pedigree. Test-day milk records on individual ewes were used to estimate several milk yield related traits, including peak milk yield and cumulative milk yield to 50 (MY50), 100 (MY100) and 250 days (MY250). These traits, as well as estimated breeding value of backcross ewes extracted from the genetic evaluation file of the entire flock, were used in interval mapping. Ovine chromosomes 2, 12, 18, 20 and 24 were identified to harbour putative QTL for different measures of milk production. The QTL on Ovis aries chromosomes (OAR) 2 and 20 mapped to locations where similar trait QTL have already been mapped in other studies, whereas QTL on OAR 12, 18 and 24 were unique to our backcross pedigree and have not been reported previously. In addition, all identified QTL regions were syntenic with bovine chromosomal segments revealed to harbour QTL affecting milk production traits, providing supporting evidence for the QTL identified here.</description><identifier>ISSN: 0268-9146</identifier><identifier>EISSN: 1365-2052</identifier><identifier>DOI: 10.1111/j.1365-2052.2010.02045.x</identifier><identifier>PMID: 20394603</identifier><identifier>CODEN: ANGEE3</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Animals ; Cattle ; Cheese - economics ; Crosses, Genetic ; Dairy farms ; Female ; Genomics ; Lactation - genetics ; Male ; Milk ; Milk - economics ; Milk - physiology ; milk production ; Ovis aries ; Pedigree ; Quantitative Trait Loci ; Quantitative Trait, Heritable ; sheep ; Sheep, Domestic - genetics ; Synteny ; United States</subject><ispartof>Animal genetics, 2010-10, Vol.41 (5), p.460-466</ispartof><rights>2010 The Authors, Animal Genetics © 2010 Stichting International Foundation for Animal Genetics</rights><rights>2010 The Authors, Animal Genetics © 2010 Stichting International Foundation for Animal Genetics.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4905-28a0b5f3100e5922b1a1c564327a076102d6b46948e223a6bae56de748aefc7f3</citedby><cites>FETCH-LOGICAL-c4905-28a0b5f3100e5922b1a1c564327a076102d6b46948e223a6bae56de748aefc7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2052.2010.02045.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2052.2010.02045.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20394603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mateescu, R.G</creatorcontrib><creatorcontrib>Thonney, M.L</creatorcontrib><title>Genetic mapping of quantitative trait loci for milk production in sheep</title><title>Animal genetics</title><addtitle>Anim Genet</addtitle><description>A backcross pedigree using dairy East Friesian rams and non-dairy Dorset ewes was established specifically to map quantitative trait loci (QTL) affecting milk production in sheep. Ninety nine microsatellite markers of an initial set of 120 were successfully genotyped and informative on 188 animals of this backcross pedigree. Test-day milk records on individual ewes were used to estimate several milk yield related traits, including peak milk yield and cumulative milk yield to 50 (MY50), 100 (MY100) and 250 days (MY250). These traits, as well as estimated breeding value of backcross ewes extracted from the genetic evaluation file of the entire flock, were used in interval mapping. Ovine chromosomes 2, 12, 18, 20 and 24 were identified to harbour putative QTL for different measures of milk production. The QTL on Ovis aries chromosomes (OAR) 2 and 20 mapped to locations where similar trait QTL have already been mapped in other studies, whereas QTL on OAR 12, 18 and 24 were unique to our backcross pedigree and have not been reported previously. In addition, all identified QTL regions were syntenic with bovine chromosomal segments revealed to harbour QTL affecting milk production traits, providing supporting evidence for the QTL identified here.</description><subject>Animals</subject><subject>Cattle</subject><subject>Cheese - economics</subject><subject>Crosses, Genetic</subject><subject>Dairy farms</subject><subject>Female</subject><subject>Genomics</subject><subject>Lactation - genetics</subject><subject>Male</subject><subject>Milk</subject><subject>Milk - economics</subject><subject>Milk - physiology</subject><subject>milk production</subject><subject>Ovis aries</subject><subject>Pedigree</subject><subject>Quantitative Trait Loci</subject><subject>Quantitative Trait, Heritable</subject><subject>sheep</subject><subject>Sheep, Domestic - genetics</subject><subject>Synteny</subject><subject>United States</subject><issn>0268-9146</issn><issn>1365-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EokvhK4AlDpyyjP_GOXCoViWAWjhABbeRk3WKt9kktRPYfnscUvbABXyxZf_em_E8QiiDNUvr9W7NhFYZB8XXHNItcJBqfXhAVseHh2QFXJusYFKfkCcx7gDAsJw9JiccRCE1iBUpS9e50dd0b4fBd9e0b-jtZLvRj3b0Pxwdg_Ujbfva06YPdO_bGzqEfjvVo-876jsavzs3PCWPGttG9-x-PyVXb8-_bN5lF5_K95uzi6yWBaTGjIVKNYIBOFVwXjHLaqWl4LmFXDPgW11JXUjjOBdWV9YpvXW5NNY1dd6IU_Jq8U093E4ujrj3sXZtazvXTxENGKkKSOJ_kbnmPOeS6US-_Ivc9VPo0jeQKam4MaJgiTILVYc-xuAaHILf23CHDHBOBXc4Dx_n4eOcCv5OBQ9J-vy-wFTt3fYo_BNDAt4swE_furv_Nsaz8nw-JX226H0c3eGot-EGdS5yhV8_lvhhw75dFvwSZeJfLHxje7TXwUe8-pycBTBjtEgd_QL_HrCa</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Mateescu, R.G</creator><creator>Thonney, M.L</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201010</creationdate><title>Genetic mapping of quantitative trait loci for milk production in sheep</title><author>Mateescu, R.G ; Thonney, M.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4905-28a0b5f3100e5922b1a1c564327a076102d6b46948e223a6bae56de748aefc7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Cattle</topic><topic>Cheese - economics</topic><topic>Crosses, Genetic</topic><topic>Dairy farms</topic><topic>Female</topic><topic>Genomics</topic><topic>Lactation - genetics</topic><topic>Male</topic><topic>Milk</topic><topic>Milk - economics</topic><topic>Milk - physiology</topic><topic>milk production</topic><topic>Ovis aries</topic><topic>Pedigree</topic><topic>Quantitative Trait Loci</topic><topic>Quantitative Trait, Heritable</topic><topic>sheep</topic><topic>Sheep, Domestic - genetics</topic><topic>Synteny</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mateescu, R.G</creatorcontrib><creatorcontrib>Thonney, M.L</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Animal genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mateescu, R.G</au><au>Thonney, M.L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic mapping of quantitative trait loci for milk production in sheep</atitle><jtitle>Animal genetics</jtitle><addtitle>Anim Genet</addtitle><date>2010-10</date><risdate>2010</risdate><volume>41</volume><issue>5</issue><spage>460</spage><epage>466</epage><pages>460-466</pages><issn>0268-9146</issn><eissn>1365-2052</eissn><coden>ANGEE3</coden><abstract>A backcross pedigree using dairy East Friesian rams and non-dairy Dorset ewes was established specifically to map quantitative trait loci (QTL) affecting milk production in sheep. Ninety nine microsatellite markers of an initial set of 120 were successfully genotyped and informative on 188 animals of this backcross pedigree. Test-day milk records on individual ewes were used to estimate several milk yield related traits, including peak milk yield and cumulative milk yield to 50 (MY50), 100 (MY100) and 250 days (MY250). These traits, as well as estimated breeding value of backcross ewes extracted from the genetic evaluation file of the entire flock, were used in interval mapping. Ovine chromosomes 2, 12, 18, 20 and 24 were identified to harbour putative QTL for different measures of milk production. The QTL on Ovis aries chromosomes (OAR) 2 and 20 mapped to locations where similar trait QTL have already been mapped in other studies, whereas QTL on OAR 12, 18 and 24 were unique to our backcross pedigree and have not been reported previously. In addition, all identified QTL regions were syntenic with bovine chromosomal segments revealed to harbour QTL affecting milk production traits, providing supporting evidence for the QTL identified here.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>20394603</pmid><doi>10.1111/j.1365-2052.2010.02045.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-9146 |
| ispartof | Animal genetics, 2010-10, Vol.41 (5), p.460-466 |
| issn | 0268-9146 1365-2052 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_808459022 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Cattle Cheese - economics Crosses, Genetic Dairy farms Female Genomics Lactation - genetics Male Milk Milk - economics Milk - physiology milk production Ovis aries Pedigree Quantitative Trait Loci Quantitative Trait, Heritable sheep Sheep, Domestic - genetics Synteny United States |
| title | Genetic mapping of quantitative trait loci for milk production in sheep |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T12%3A30%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20mapping%20of%20quantitative%20trait%20loci%20for%20milk%20production%20in%20sheep&rft.jtitle=Animal%20genetics&rft.au=Mateescu,%20R.G&rft.date=2010-10&rft.volume=41&rft.issue=5&rft.spage=460&rft.epage=466&rft.pages=460-466&rft.issn=0268-9146&rft.eissn=1365-2052&rft.coden=ANGEE3&rft_id=info:doi/10.1111/j.1365-2052.2010.02045.x&rft_dat=%3Cproquest_cross%3E808459022%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1545288391&rft_id=info:pmid/20394603&rfr_iscdi=true |