Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus
Summary Background Several surgical techniques are available for the treatment of stable leucoderma. The use of noncultured epidermal cellular grafting was introduced in 1992. Data on long‐term follow‐up regarding stability of the repigmented area, time to achieve the final repigmentation, colour m...
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| Veröffentlicht in: | British journal of dermatology (1951) 2010-12, Vol.163 (6), p.1186-1193 |
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| creator | Van Geel, N. Wallaeys, E. Goh, B.K. De Mil, M. Lambert, J. |
| description | Summary
Background Several surgical techniques are available for the treatment of stable leucoderma. The use of noncultured epidermal cellular grafting was introduced in 1992. Data on long‐term follow‐up regarding stability of the repigmented area, time to achieve the final repigmentation, colour matching, reaction to sun exposure and patient satisfaction with treatment have been reported only a few times previously.
Objectives To evaluate the long‐term results of the noncultured epidermal cellular grafting technique in patients with different types of leucoderma, including segmental vitiligo (n = 33), generalized vitiligo (n = 33), mixed vitiligo (n = 6), halo naevi (n = 11), piebaldism (n = 3) and naevus depigmentosus (n = 1).
Methods Patients were evaluated by examination and questionnaire in a retrospective setting after transplantation by autologous noncultured cellular grafting. Percentage of repigmentation was evaluated in 82 patients using a digital imaging analysis system (mean follow‐up 15 months). Long‐term results were evaluated by 54 patients using a questionnaire up to 7·7 years after treatment (mean 4 years).
Results More than 75% repigmentation was achieved in 71% of patients. Best results were obtained in segmental vitiligo, halo naevi and piebaldism, whereas results in generalized or mixed vitiligo were inferior. According to the patients, final repigmentation was achieved after a mean of 10 months post‐treatment. In 80% some colour mismatch (hyperpigmentation and hypopigmentation) was reported between the treated area and the surrounding skin, although this was not disturbing for the majority. This colour mismatch was reported significantly less after sun exposure (P = 0·012). During follow‐up 7% of patients, all with generalized vitiligo, observed some loss of the achieved repigmentation.
Conclusions Autologous epidermal cellular grafting achieved a high percentage of repigmentation, which was maintained during follow‐up in the majority of patients. Although it improved quality of life, a perfect colour match was seldom obtained. |
| doi_str_mv | 10.1111/j.1365-2133.2010.10014.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_808454542</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>808454542</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4544-10d3bbcab776704de3170743224934964a1e1fc69bac94e1e17e079d14b6de023</originalsourceid><addsrcrecordid>eNpFkUFv0zAUxy0EYt3gKyBfEJelPMdO3FyQ2IABioADMG6Wk7wEF8fp7GRrvz1OW4ovfn7vp59l_wmhDJYsrtfrJeN5lqSM82UKcxeAieX2EVmcBo_JAgBkAkXOz8h5COvIcMjgKTlLYQVCFLAgu3JwXTKi76nHMNkx0KGlbnB1rCePDcWNaeJYW1qjtZPVnnZet6NxHTWO3pvRWNMNl_S3tgN1Gu_NJd0YrLRtTOipds2-OwXaRFfXoxuHMIVn5EmrbcDnx_2C_Pjw_vv1x6T8evPp-m2Z1CITImHQ8KqqdSVlLkE0yJkEKXiaioKLIheaIWvrvKh0XQiMB4kgi4aJKm8QUn5BXh28Gz_cTRhG1ZswP0U7HKagVrCKF2ViJl8cyanqsVEbb3rtd-rfb0Xg5RHQoda29drVJvzneBbJbBa9OXAPxuLuNGeg5vTUWs0hqTkkNaen9umprbr6_G5fRkFyEJgw4vYk0P6PyiWXmbr9cqN-Qnn7q_x2pTj_C-BLnXA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>808454542</pqid></control><display><type>article</type><title>Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Van Geel, N. ; Wallaeys, E. ; Goh, B.K. ; De Mil, M. ; Lambert, J.</creator><creatorcontrib>Van Geel, N. ; Wallaeys, E. ; Goh, B.K. ; De Mil, M. ; Lambert, J.</creatorcontrib><description>Summary
Background Several surgical techniques are available for the treatment of stable leucoderma. The use of noncultured epidermal cellular grafting was introduced in 1992. Data on long‐term follow‐up regarding stability of the repigmented area, time to achieve the final repigmentation, colour matching, reaction to sun exposure and patient satisfaction with treatment have been reported only a few times previously.
Objectives To evaluate the long‐term results of the noncultured epidermal cellular grafting technique in patients with different types of leucoderma, including segmental vitiligo (n = 33), generalized vitiligo (n = 33), mixed vitiligo (n = 6), halo naevi (n = 11), piebaldism (n = 3) and naevus depigmentosus (n = 1).
Methods Patients were evaluated by examination and questionnaire in a retrospective setting after transplantation by autologous noncultured cellular grafting. Percentage of repigmentation was evaluated in 82 patients using a digital imaging analysis system (mean follow‐up 15 months). Long‐term results were evaluated by 54 patients using a questionnaire up to 7·7 years after treatment (mean 4 years).
Results More than 75% repigmentation was achieved in 71% of patients. Best results were obtained in segmental vitiligo, halo naevi and piebaldism, whereas results in generalized or mixed vitiligo were inferior. According to the patients, final repigmentation was achieved after a mean of 10 months post‐treatment. In 80% some colour mismatch (hyperpigmentation and hypopigmentation) was reported between the treated area and the surrounding skin, although this was not disturbing for the majority. This colour mismatch was reported significantly less after sun exposure (P = 0·012). During follow‐up 7% of patients, all with generalized vitiligo, observed some loss of the achieved repigmentation.
Conclusions Autologous epidermal cellular grafting achieved a high percentage of repigmentation, which was maintained during follow‐up in the majority of patients. Although it improved quality of life, a perfect colour match was seldom obtained.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2010.10014.x</identifier><identifier>PMID: 20804490</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aminoacid disorders ; Biological and medical sciences ; Cell Transplantation - methods ; Child ; Dermatology ; Epidermis - cytology ; Errors of metabolism ; Female ; grafting ; halo naevi ; Humans ; Male ; Medical sciences ; melanocyte transplantation ; Metabolic diseases ; Middle Aged ; naevus depigmentosus ; Nevus - pathology ; Nevus - surgery ; Patient Satisfaction ; piebaldism ; Piebaldism - pathology ; Piebaldism - surgery ; Pigmentary diseases of the skin ; Retrospective Studies ; Skin Neoplasms - pathology ; Skin Neoplasms - surgery ; Skin Pigmentation ; Surveys and Questionnaires ; Transplantation, Autologous ; Tumors of the skin and soft tissue. Premalignant lesions ; vitiligo ; Vitiligo - pathology ; Vitiligo - surgery ; Young Adult</subject><ispartof>British journal of dermatology (1951), 2010-12, Vol.163 (6), p.1186-1193</ispartof><rights>2010 The Authors. BJD © 2010 British Association of Dermatologists</rights><rights>2015 INIST-CNRS</rights><rights>2010 The Authors. BJD © 2010 British Association of Dermatologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4544-10d3bbcab776704de3170743224934964a1e1fc69bac94e1e17e079d14b6de023</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2010.10014.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2010.10014.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23508052$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20804490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Geel, N.</creatorcontrib><creatorcontrib>Wallaeys, E.</creatorcontrib><creatorcontrib>Goh, B.K.</creatorcontrib><creatorcontrib>De Mil, M.</creatorcontrib><creatorcontrib>Lambert, J.</creatorcontrib><title>Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Several surgical techniques are available for the treatment of stable leucoderma. The use of noncultured epidermal cellular grafting was introduced in 1992. Data on long‐term follow‐up regarding stability of the repigmented area, time to achieve the final repigmentation, colour matching, reaction to sun exposure and patient satisfaction with treatment have been reported only a few times previously.
Objectives To evaluate the long‐term results of the noncultured epidermal cellular grafting technique in patients with different types of leucoderma, including segmental vitiligo (n = 33), generalized vitiligo (n = 33), mixed vitiligo (n = 6), halo naevi (n = 11), piebaldism (n = 3) and naevus depigmentosus (n = 1).
Methods Patients were evaluated by examination and questionnaire in a retrospective setting after transplantation by autologous noncultured cellular grafting. Percentage of repigmentation was evaluated in 82 patients using a digital imaging analysis system (mean follow‐up 15 months). Long‐term results were evaluated by 54 patients using a questionnaire up to 7·7 years after treatment (mean 4 years).
Results More than 75% repigmentation was achieved in 71% of patients. Best results were obtained in segmental vitiligo, halo naevi and piebaldism, whereas results in generalized or mixed vitiligo were inferior. According to the patients, final repigmentation was achieved after a mean of 10 months post‐treatment. In 80% some colour mismatch (hyperpigmentation and hypopigmentation) was reported between the treated area and the surrounding skin, although this was not disturbing for the majority. This colour mismatch was reported significantly less after sun exposure (P = 0·012). During follow‐up 7% of patients, all with generalized vitiligo, observed some loss of the achieved repigmentation.
Conclusions Autologous epidermal cellular grafting achieved a high percentage of repigmentation, which was maintained during follow‐up in the majority of patients. Although it improved quality of life, a perfect colour match was seldom obtained.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aminoacid disorders</subject><subject>Biological and medical sciences</subject><subject>Cell Transplantation - methods</subject><subject>Child</subject><subject>Dermatology</subject><subject>Epidermis - cytology</subject><subject>Errors of metabolism</subject><subject>Female</subject><subject>grafting</subject><subject>halo naevi</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>melanocyte transplantation</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>naevus depigmentosus</subject><subject>Nevus - pathology</subject><subject>Nevus - surgery</subject><subject>Patient Satisfaction</subject><subject>piebaldism</subject><subject>Piebaldism - pathology</subject><subject>Piebaldism - surgery</subject><subject>Pigmentary diseases of the skin</subject><subject>Retrospective Studies</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - surgery</subject><subject>Skin Pigmentation</subject><subject>Surveys and Questionnaires</subject><subject>Transplantation, Autologous</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>vitiligo</subject><subject>Vitiligo - pathology</subject><subject>Vitiligo - surgery</subject><subject>Young Adult</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUFv0zAUxy0EYt3gKyBfEJelPMdO3FyQ2IABioADMG6Wk7wEF8fp7GRrvz1OW4ovfn7vp59l_wmhDJYsrtfrJeN5lqSM82UKcxeAieX2EVmcBo_JAgBkAkXOz8h5COvIcMjgKTlLYQVCFLAgu3JwXTKi76nHMNkx0KGlbnB1rCePDcWNaeJYW1qjtZPVnnZet6NxHTWO3pvRWNMNl_S3tgN1Gu_NJd0YrLRtTOipds2-OwXaRFfXoxuHMIVn5EmrbcDnx_2C_Pjw_vv1x6T8evPp-m2Z1CITImHQ8KqqdSVlLkE0yJkEKXiaioKLIheaIWvrvKh0XQiMB4kgi4aJKm8QUn5BXh28Gz_cTRhG1ZswP0U7HKagVrCKF2ViJl8cyanqsVEbb3rtd-rfb0Xg5RHQoda29drVJvzneBbJbBa9OXAPxuLuNGeg5vTUWs0hqTkkNaen9umprbr6_G5fRkFyEJgw4vYk0P6PyiWXmbr9cqN-Qnn7q_x2pTj_C-BLnXA</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Van Geel, N.</creator><creator>Wallaeys, E.</creator><creator>Goh, B.K.</creator><creator>De Mil, M.</creator><creator>Lambert, J.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201012</creationdate><title>Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus</title><author>Van Geel, N. ; Wallaeys, E. ; Goh, B.K. ; De Mil, M. ; Lambert, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4544-10d3bbcab776704de3170743224934964a1e1fc69bac94e1e17e079d14b6de023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aminoacid disorders</topic><topic>Biological and medical sciences</topic><topic>Cell Transplantation - methods</topic><topic>Child</topic><topic>Dermatology</topic><topic>Epidermis - cytology</topic><topic>Errors of metabolism</topic><topic>Female</topic><topic>grafting</topic><topic>halo naevi</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>melanocyte transplantation</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>naevus depigmentosus</topic><topic>Nevus - pathology</topic><topic>Nevus - surgery</topic><topic>Patient Satisfaction</topic><topic>piebaldism</topic><topic>Piebaldism - pathology</topic><topic>Piebaldism - surgery</topic><topic>Pigmentary diseases of the skin</topic><topic>Retrospective Studies</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - surgery</topic><topic>Skin Pigmentation</topic><topic>Surveys and Questionnaires</topic><topic>Transplantation, Autologous</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>vitiligo</topic><topic>Vitiligo - pathology</topic><topic>Vitiligo - surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Geel, N.</creatorcontrib><creatorcontrib>Wallaeys, E.</creatorcontrib><creatorcontrib>Goh, B.K.</creatorcontrib><creatorcontrib>De Mil, M.</creatorcontrib><creatorcontrib>Lambert, J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Geel, N.</au><au>Wallaeys, E.</au><au>Goh, B.K.</au><au>De Mil, M.</au><au>Lambert, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2010-12</date><risdate>2010</risdate><volume>163</volume><issue>6</issue><spage>1186</spage><epage>1193</epage><pages>1186-1193</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background Several surgical techniques are available for the treatment of stable leucoderma. The use of noncultured epidermal cellular grafting was introduced in 1992. Data on long‐term follow‐up regarding stability of the repigmented area, time to achieve the final repigmentation, colour matching, reaction to sun exposure and patient satisfaction with treatment have been reported only a few times previously.
Objectives To evaluate the long‐term results of the noncultured epidermal cellular grafting technique in patients with different types of leucoderma, including segmental vitiligo (n = 33), generalized vitiligo (n = 33), mixed vitiligo (n = 6), halo naevi (n = 11), piebaldism (n = 3) and naevus depigmentosus (n = 1).
Methods Patients were evaluated by examination and questionnaire in a retrospective setting after transplantation by autologous noncultured cellular grafting. Percentage of repigmentation was evaluated in 82 patients using a digital imaging analysis system (mean follow‐up 15 months). Long‐term results were evaluated by 54 patients using a questionnaire up to 7·7 years after treatment (mean 4 years).
Results More than 75% repigmentation was achieved in 71% of patients. Best results were obtained in segmental vitiligo, halo naevi and piebaldism, whereas results in generalized or mixed vitiligo were inferior. According to the patients, final repigmentation was achieved after a mean of 10 months post‐treatment. In 80% some colour mismatch (hyperpigmentation and hypopigmentation) was reported between the treated area and the surrounding skin, although this was not disturbing for the majority. This colour mismatch was reported significantly less after sun exposure (P = 0·012). During follow‐up 7% of patients, all with generalized vitiligo, observed some loss of the achieved repigmentation.
Conclusions Autologous epidermal cellular grafting achieved a high percentage of repigmentation, which was maintained during follow‐up in the majority of patients. Although it improved quality of life, a perfect colour match was seldom obtained.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20804490</pmid><doi>10.1111/j.1365-2133.2010.10014.x</doi><tpages>8</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Aminoacid disorders Biological and medical sciences Cell Transplantation - methods Child Dermatology Epidermis - cytology Errors of metabolism Female grafting halo naevi Humans Male Medical sciences melanocyte transplantation Metabolic diseases Middle Aged naevus depigmentosus Nevus - pathology Nevus - surgery Patient Satisfaction piebaldism Piebaldism - pathology Piebaldism - surgery Pigmentary diseases of the skin Retrospective Studies Skin Neoplasms - pathology Skin Neoplasms - surgery Skin Pigmentation Surveys and Questionnaires Transplantation, Autologous Tumors of the skin and soft tissue. Premalignant lesions vitiligo Vitiligo - pathology Vitiligo - surgery Young Adult |
| title | Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus |
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